Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments

Molecules, Journal Year: 2021, Volume and Issue: 26(10), P. 3007 - 3007

Published: May 18, 2021

After tooth loss, bone resorption is irreversible, leaving the area without adequate volume for successful implant treatment. Bone grafting only solution to reverse dental loss and a well-accepted procedure required in one every four implants. Research development materials, design fabrication technologies have expanded over years achieve long-lasting implants substitution. This review will critically present various graft substitute materials that been used implant. The article also reviews properties of grafts substitutes studied or are currently available commercially. classifications substitutes, including natural synthetic presented, commercial products each category discussed. Different metals, ceramics, polymers, their combinations, chemical, physical, biocompatibility explored. Limitations areas which require further research highlighted. Tissue engineering hybrid constructions with enhanced regeneration ability, such as cell-based growth factor-based discussed an emerging development.

Language: Английский

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Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering

Polymers, Journal Year: 2021, Volume and Issue: 13(4), P. 599 - 599

Published: Feb. 17, 2021

Collagen type I is the main organic constituent of bone extracellular matrix and has been used for decades as scaffolding material in tissue engineering approaches when autografts are not feasible. Polymeric collagen can be easily isolated from various animal sources processed a great number ways to manufacture biomaterials form sponges, particles, or hydrogels, among others, different applications. Despite its biocompatibility osteoconductivity, also some drawbacks, such high biodegradability, low mechanical strength, lack osteoinductive activity. Therefore, many attempts have made improve I-based implants engineering. This review aims summarize current status biomaterial engineering, well highlight efforts that recently towards designing producing regeneration.

Language: Английский

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Nano-Hydroxyapatite Composite Scaffolds Loaded with Bioactive Factors and Drugs for Bone Tissue Engineering

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1291 - 1291

Published: Jan. 9, 2023

Nano-hydroxyapatite (n-HAp) is similar to human bone mineral in structure and biochemistry is, therefore, widely used as biomaterial a drug carrier. Further, n-HAp composite scaffolds have great potential role regeneration. Loading bioactive factors drugs onto composites has emerged promising strategy for defect repair tissue engineering. With local delivery of agents drugs, biological materials may be provided with the activity they lack improve This review summarizes classification composites, application loaded engineering loading methods scaffolds, research direction future prospected.

Language: Английский

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Bone tissue engineering: Anionic polysaccharides as promising scaffolds

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 283, P. 119142 - 119142

Published: Jan. 18, 2022

Language: Английский

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Application of decellularized bone matrix as a bioscaffold in bone tissue engineering

Journal of Biological Engineering, Journal Year: 2022, Volume and Issue: 16(1)

Published: Jan. 5, 2022

Autologous bone grafts are commonly used as the gold standard to repair and regenerate diseased bones. However, they strongly associated with postoperative complications, especially at donor site, increased surgical costs. In an effort overcome these limitations, tissue engineering (TE) has been proposed alternative promote repair. The successful outcome of depends on microstructure composition materials scaffold. Decellularized matrix-based biomaterials have applied bioscaffolds in engineering. These play important role providing mechanical physical microenvironment needed by cells proliferate survive. extracellular matrix (dECM) can be a powder, hydrogel electrospun scaffolds. mimic native due their structure similar original tissue. aim this review is highlight decellularization techniques. Herein we discuss: (1) structure; (2) properties ideal scaffold; (3) potential decellularized bioscaffolds; (4) terminal sterilization bone; (5) cell removing confirmation tissues; (6) post procedures. Finally, improvement formation dECM immunogenicity aspect using presented, illustrate how novel dECM-based bioscaffold A comprehensive understanding may allow for better incorporation therapeutic approaches defects allowing regeneration.

Language: Английский

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Electrospun Biomimetic Nanofibrous Scaffolds: A Promising Prospect for Bone Tissue Engineering and Regenerative Medicine

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(16), P. 9206 - 9206

Published: Aug. 16, 2022

Skeletal-related disorders such as arthritis, bone cancer, osteosarcoma, and osteoarthritis are among the most common reasons for mortality in humans at present. Nanostructured scaffolds have been discovered to be more efficient regeneration than macro/micro-sized because they sufficiently permit cell adhesion, proliferation, chemical transformation. Nanofibrous mimicking artificial extracellular matrices provide a natural environment tissue owing their large surface area, high porosity, appreciable drug loading capacity. Here, we review recent progress possible future prospective electrospun nanofibrous engineering. Electrospun demonstrated promising potential using variety of nanomaterials. This focused on crucial role biological applications, including drug/growth factor delivery regeneration. Natural synthetic polymeric extensively inspected regenerate tissue. We mainly significant impact composite adhesion function, different composites organic/inorganic nanoparticles with nanofiber scaffolds. analysis provides an overview scaffold-based strategies; however, same concepts can applied other organ tactics.

Language: Английский

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Advances in Biodegradable Polymers and Biomaterials for Medical Applications—A Review

Molecules, Journal Year: 2023, Volume and Issue: 28(17), P. 6213 - 6213

Published: Aug. 24, 2023

The introduction of new materials for the production various types constructs that can connect directly to tissues has enabled development such fields science as medicine, tissue, and regenerative engineering. implementation these materials, called biomaterials, contributed a significant improvement in quality human life terms health. This is due constantly growing availability implants, prostheses, tools, surgical equipment, which, thanks their specific features biocompatibility, appropriate mechanical properties, ease sterilization, high porosity, ensure an living. Biodegradation ensures, among other things, ideal rate regenerated tissue. Current tissue engineering medicine strategies aim restore function damaged tissues. current gold standard autografts (using patient’s accelerate healing), but limitations limited procurement certain tissues, long operative time, donor site morbidity have warranted search alternative options. use biomaterials this purpose attractive option number being developed tested rapidly.

Language: Английский

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Hydrogels and Bioprinting in Bone Tissue Engineering: Creating Artificial Stem‐Cell Niches for In Vitro Models

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(52)

Published: April 23, 2023

Advances in bioprinting have enabled the fabrication of complex tissue constructs with high speed and resolution. However, there remains significant structural biological complexity within tissues that is unable to recapitulate. Bone, for example, has a hierarchical organization ranging from molecular whole organ level. Current techniques materials employed imposed limits on scale, speed, resolution can be achieved, rendering technique reproduce hierarchies cell-matrix interactions are observed bone. The shift toward biomimetic approaches bone engineering, where hydrogels provide biophysical biochemical cues encapsulated cells, promising approach enhancing function development vitro modeling. A major focus modeling creating dynamic microenvironmental niches support, stimulate, direct cellular processes formation remodeling. Hydrogels ideal imitating extracellular matrix since they engineered present various whilst allowing bioprinting. Here, recent advances 3D niche conducive engineering models reviewed.

Language: Английский

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Leveraging the Recent Advancements in GelMA Scaffolds for Bone Tissue Engineering: An Assessment of Challenges and Opportunities

Biomacromolecules, Journal Year: 2023, Volume and Issue: 25(4), P. 2075 - 2113

Published: July 5, 2023

The field of bone tissue engineering has seen significant advancements in recent years. Each year, over two million transplants are performed globally, and conventional treatments, such as grafts metallic implants, have their limitations. Tissue offers a new level treatment, allowing for the creation living within biomaterial framework. Recent advances biomaterials provided innovative approaches to rebuilding function after damage. Among them, gelatin methacryloyl (GelMA) hydrogel is emerging promising supporting cell proliferation regeneration, GelMA exhibited exceptional physicochemical biological properties, making it viable option clinical translation. Various methods classes additives been used application with incorporation nanofillers or other polymers enhancing its resilience functional performance. Despite results, fabrication complex structures that mimic architecture provision balanced physical properties both vasculature growth proper stiffness load bearing remain challenges. In terms utilizing osteogenic additives, priority should be on versatile components promote angiogenesis osteogenesis while reinforcing structure applications. This review focuses efforts advantages GelMA-based composite engineering, covering literature from last five

Language: Английский

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Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(8), P. 5082 - 5106

Published: July 15, 2024

In view of their exceptional approach, excellent inherent biocompatibility and biodegradability properties, interaction with the local extracellular matrix, protein-based polymers have received attention in bone tissue engineering, which is a multidisciplinary field that repairs regenerates fractured bones. Bone multihierarchical complex structure, it performs several essential biofunctions, including maintaining mineral balance structural support protecting soft organs. Protein-based gained interest developing ideal scaffolds as emerging biomaterials for healing regeneration, challenging to design substitutes perfect biomaterials. Several polymers, collagen, keratin, gelatin, serum albumin, etc., are potential materials due cytocompatibility, controlled biodegradability, high biofunctionalization, tunable mechanical characteristics. While numerous studies indicated encouraging possibilities proteins BTE, there still major challenges concerning stability physiological conditions, continuous release growth factors bioactive molecules. Robust derived from can be used replace broken or diseased biocompatible substitute; proteins, being biopolymers, provide engineering. Herein, recent developments protein cutting-edge engineering addressed this review within 3–5 years, focus on significant future perspectives. The first section discusses fundamentals anatomy scaffolds, second describes fabrication techniques scaffolds. third highlights importance applications BTE. Hence, development state-of-the-art has been discussed, highlighting

Language: Английский

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