Effects-based monitoring of bioactive compounds associated with municipal wastewater treatment plant effluent discharge to the South Platte River, Colorado, USA

Environmental Pollution, Journal Year: 2021, Volume and Issue: 289, P. 117928 - 117928

Published: Aug. 6, 2021

Language: Английский

---

Application of in vitro bioassays to monitor pharmaceuticals in water: A synthesis of chronological analysis, mode of action, and practical insights

Chemosphere, Journal Year: 2024, Volume and Issue: 359, P. 142255 - 142255

Published: May 9, 2024

Pharmaceutical compounds in wastewater have emerged as a significant concern for the aquatic environment. The use of vitro bioassays represents sustainable and cost-effective approach assessing potential toxicological risks these biologically active aligns with ethical considerations research. It facilitates high-throughput analysis, captures mixture effects, integrates impacts both known unknown chemicals, reduces reliance on animal testing. core aim current review was to explore practical application evaluating environmental pharmaceuticals wastewater. This comprehensive strives achieve several key objectives. First, it provides summary categorisation based their mode action, providing structured framework understanding ecological significance. Second, chronological analysis pharmaceutical research aims document prevalence trends over time, shedding light evolving challenges. Third, critically analyses existing bioassay applications wastewater, while also examining coverage representative within major classes. Finally, explores developing innovative tailored water quality monitoring pharmaceuticals, paving way more robust risk assessment. Overall, adopting effect-based methods holds promise. encompasses broad spectrum biological impacts, promotes standardized protocols, supports test battery indicative different endpoints, thereby enhancing effectiveness

Language: Английский

---

Integrated toxicity of secondary, tertiary, wetland effluents on human stem cells triggered by ERα and PPARγ agonists

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 937, P. 173419 - 173419

Published: May 25, 2024

Language: Английский

---

An estrogenic municipal effluent decreased fathead minnow reproduction to a near stop

Chemosphere, Journal Year: 2024, Volume and Issue: 370, P. 143957 - 143957

Published: Dec. 21, 2024

Language: Английский

---

Changes in chemical occurrence, concentration, and bioactivity in the Colorado River before and after replacement of the Moab, Utah wastewater treatment plant

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 904, P. 166231 - 166231

Published: Aug. 14, 2023

Long-term (2010-19) water-quality monitoring on the Colorado River downstream from Moab Utah indicated persistent presence of Bioactive Chemicals (BC), such as pesticides and pharmaceuticals. This stream reach near Canyonlands National Park provides critical habitat for federally endangered species. The wastewater treatment plant (WWTP) outfall discharges to is nearest potential point-source this reach. original WWTP was replaced in 2018. In 2016-19, a study completed determine if new reduced BC input at, from, outfall. Water samples were collected before after replacement at sites upstream Samples analyzed many 243 pesticides, 109 pharmaceuticals, 20 hormones, 51 indicator chemicals, metals, 8 nutrients. concentrations, hazard quotients (HQs), exposure activity ratios (EARs) used identify prioritize contaminants their have adverse biological effects health native wildlife. There 22 with HQs >1, mostly metals hormones; 23 EARs >0.1, hormones Most high or associated site prior its replacement. Discharge had concentrations nutrients, other BC. For example, all 16 detected maximum less effect instream whose sources are directly tied domestic wastewater. Study results indicate that improved technology can create substantial reductions non-regulated addition regulated

Language: Английский

---

Prediction and Verification of Epimedium Flavonoids With Different Glycosylation Numbers in Reversing Glucocorticoid-Induced Bone Formation Inhibition by Molecular Docking and Zebrafish

Frontiers in Environmental Science, Journal Year: 2022, Volume and Issue: 9

Published: Feb. 8, 2022

Glucocorticoids have been detected in environmental waters, and their biological potency has raised concerns on impact aquatic vertebrates especially fish. Numerous researches showed that the continuous direct contact of with glucocorticoid contaminants water will cause bone formation inhibition. The aim this study is to predict verify effect icaritin (IT), icariin (ICA), baohuside-I (BHG-I) reversing glucocorticoid-induced inhibition (GIBFI) by molecular docking zebrafish model. We contrasted activity GIBFI from affinity metabolism proteins (OPG, RANKL, BMP-2, BMP-4, Runx-2) docking. Subsequently, model was adopted evaluate reverse effects GIBFI. Alizarin red staining coupled image quantification were performed ICA, IT, BHG-I skeleton stained area (SSA) cumulative optical density (COD). Inductively plasma-mass spectrometry applied determine contents mineral elements (CBME, Mg, K, Ca, Fe, Zn) bones. Docking results receptors (BMP-2, Runx2) all combined well while bound OPG, between IT above targets weakest. Fortunately, significantly increased SSA, COD, Ca compared group ( p < 0.05) order IT>ICA>BHG-I. In conclusion, glycosyl groups H-bond flavonoids target sites, which weakened formation. BHG-I, ICA alleviated GIBFI, but intensity

Language: Английский

---

Risk to Receiving Water Bodies Related to Oestrogenic Activity of Wastewater Treatment Plant Effluents Estimated Through Effect-Based Trigger Values

Published: Jan. 1, 2024

Language: Английский

---

Comparative Endpoint Sensitivity of Bioanalytical Tools for Glucocorticoid Receptor Agonism Surveillance in Aquatic Matrices

ACS ES&T Water, Journal Year: 2023, Volume and Issue: 3(9), P. 3082 - 3092

Published: Aug. 25, 2023

Synthetic glucocorticoids, which occur globally in wastewater effluent discharges, surface waters, and reuse projects, are endocrine disruptors contaminants of emerging concern (CECs) relevance for water quality surveillance. Because diverse bioanalytical tools increasingly employed as new approach methodologies vitro to vivo extrapolations assessments, including glucocorticoid receptor (GR) agonist activity, we examined endpoint sensitivities multiple common methods. We probabilistic environmental hazard assessments initially examine the likelihood each assay identifying GR hazards discharges waters. then used chemical toxicity distributions advance an understanding relative sensitivity among assays by these CECs elicit agonistic response at environmentally relevant concentrations. observed commercially available other reported refereed literature generally be more sensitive than any included ToxCast efforts. Our observations emphasize importance further studies inform selection, use, interpretation responses within during extrapolation detection activity assessments.

Language: Английский

---

Changes in Chemical Occurrence, Concentration, and Bioactivity in the Colorado River Before and after Replacement of the Moab, Utah Wastewater Treatment Plant

Published: Jan. 1, 2023

Long-term (2010-19) water-quality monitoring on the Colorado River downstream from Moab Utah indicated persistent presence of Bioactive Chemicals (BC), such as pesticides and pharmaceuticals. This stream reach near Canyonlands National Park provides critical habitat for federally endangered species. The wastewater treatment plant (WWTP) outfall discharges to is nearest potential point-source this reach. original WWTP was replaced in 2018. In 2016-19, a study completed determine if new reduced BC input at, from, outfall. Water samples were collected before after replacement at sites upstream Samples analyzed many 243 pesticides, 109 pharmaceuticals, 20 hormones, 51 indicator chemicals, metals, 8 nutrients. concentrations, hazard quotients (HQs), exposure activity ratios (EARs) used identify prioritize contaminants their have adverse biological effects health native wildlife. There 22 with HQs greater than 1, mostly metals hormones; 23 EARs 0.1, hormones Most high or associated site prior its replacement. Discharge had concentrations nutrients, other BC. For example, all 16 detected maximum less effect instream whose sources are directly tied domestic wastewater. Study results indicate that improved technology can create substantial reductions non-regulated addition regulated

Language: Английский

---

Variation of interception efficiency and transformation to natural glucocorticoids in three texture reclaimed water receiving riverbeds

Journal of the Taiwan Institute of Chemical Engineers, Journal Year: 2023, Volume and Issue: unknown, P. 105242 - 105242

Published: Nov. 1, 2023

Language: Английский

---