Respiratory virus concentrations in human excretions that contribute to wastewater: a systematic review and meta-analysis

Journal of Water and Health, Journal Year: 2023, Volume and Issue: 21(6), P. 831 - 848

Published: May 16, 2023

Concentrations of nucleic acids from a range respiratory viruses in wastewater solids collected treatment plants correlate to clinical data on disease occurrence the community contributing wastewater. Viral enter excretions deposited toilets or drains. To relate measured concentrations at plant number infections, viral nucleic-acid human are needed as inputs mass balance model. Here, we carried out systematic review and meta-analysis characterize presence influenza A B, syncytial virus, metapneumovirus, parainfluenza rhinovirus, seasonal coronaviruses stool, urine, mucus, sputum, saliva. We identified 220 sets 50 articles reported these excretions. Data were unevenly distributed across virus type (with most available for influenza) excretion excretions). Most only absence cross-sectional study design. There is need more concentration data, including longitudinal all types. Such would allow quantitatively linking numbers infected individuals.

Language: Английский

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Wastewater Detection of Emerging Arbovirus Infections: Case Study of Dengue in the United States

Environmental Science & Technology Letters, Journal Year: 2023, Volume and Issue: 11(1), P. 9 - 15

Published: Dec. 11, 2023

Climate change and urbanization are increasing the distribution of insect vectors infectious diseases. Dengue virus is an arbovirus that causes nearly 100 million symptomatic infections per year endemic in 124 countries, range its mosquito continues to increase. Surveillance dengue complicated by fact can be asymptomatic, symptoms may not readily recognizable clinicians. Here we show wastewater monitoring used detect RNA yield information about circulation a community. We collected three samples solids week from different treatment plants Miami-Dade County, Florida, where were locally acquired. Using molecular methods, tested for 4 serotypes consistently detected 3 at all did other serotypes. According publicly available data on infections, vast majority caused serotype 3. Wastewater detection possible with as few 4.23 laboratory confirmed cases 1 people based infection data.

Language: Английский

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A retrospective longitudinal study of adenovirus group F, norovirus GI and GII, rotavirus, and enterovirus nucleic acids in wastewater solids at two wastewater treatment plants: solid-liquid partitioning and relation to clinical testing data

mSphere, Journal Year: 2024, Volume and Issue: 9(3)

Published: Feb. 27, 2024

Enteric infections are important causes of morbidity and mortality, yet clinical surveillance is limited. Wastewater-based epidemiology (WBE) has been used to study community circulation individual enteric viruses panels respiratory diseases, but there limited work studying the concurrent a suite viruses. A retrospective WBE was carried out at two wastewater treatment plants located in California, United States. Using digital droplet polymerase chain reaction (PCR), we measured concentrations human adenovirus group F, enteroviruses, norovirus genogroups I II, rotavirus nucleic acids solids times per week for 26 months (

Language: Английский

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From capture to detection: A critical review of passive sampling techniques for pathogen surveillance in water and wastewater

Water Research, Journal Year: 2024, Volume and Issue: 261, P. 122024 - 122024

Published: June 30, 2024

Water quality, critical for human survival and well-being, necessitates rigorous control to mitigate contamination risks, particularly from pathogens amid expanding urbanization. Consequently, the necessity maintain microbiological safety of water supplies demands effective surveillance strategies, reliant on collection representative samples precise measurement contaminants. This review critically examines advancements passive sampling techniques monitoring in various systems, including wastewater, freshwater, seawater. We explore evolution conventional materials innovative adsorbents pathogen capture shift culture-based molecular detection methods, underscoring adaptation this field global health challenges. The comparison highlights sampling's efficacy over like grab its potential overcome existing challenges through use such as granular activated carbon, thermoplastics, polymer membranes. By evaluating literature, work identifies standardization gaps proposes future research directions augment efficiency, specificity, utility environmental public surveillance.

Language: Английский

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Detection of Hemagglutinin H5 influenza A virus RNA and model of potential inputs in an urban California sewershed

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Abstract In 2024, the highly pathogenic avian influenza A H5N1 caused outbreaks in wild birds, poultry, cows, and other mammals United States with 61 human cases also reported by CDC. Detection of H5 RNA wastewater has been previously sewersheds Texas North Carolina nearby impacted dairy herds following emergence cows. Here, we conduct retrospective testing total hemagglutinin genes as well presenting applying new assays for detection H1 H3 across a respiratory virus season an urban California sewershed from September 2023 – May 2024. Total A, H1, were regularly detected, while was first detected March. We developed model that uses Monte Carlo simulations published parameters to estimate numbers infected people, or liters H5-contaminated milk required result measured concentrations wastewater. Our findings demonstrate this sewershed, contaminated poultry most likely sources created publicly available tool apply input inputs. Synopsis understand potential wastewater, enabling interpretation detections. TOC figure

Language: Английский

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