Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(11), P. 4937 - 4947
Published: March 6, 2024
Bis(2-ethylhexyl)-tetrabromophthalate
(TBPH),
a
typical
novel
brominated
flame
retardant,
has
been
ubiquitously
identified
in
various
environmental
and
biotic
media.
Consequently,
there
is
an
urgent
need
for
precise
risk
assessment
based
on
comprehensive
understanding
of
internal
exposure
the
corresponding
toxic
effects
specific
tissues.
In
this
study,
we
first
investigated
toxicokinetic
characteristics
TBPH
different
tissues
using
classical
pseudo-first-order
model.
We
found
that
was
prone
to
accumulate
liver
rather
than
gonad,
brain,
muscle
both
female
male
zebrafish,
highlighting
higher
liver.
Furthermore,
long-term
at
environmentally
relevant
concentrations
led
increased
visceral
fat
accumulation,
signaling
potential
abnormal
function.
Hepatic
transcriptome
analysis
predominantly
implicated
glycolipid
metabolism
pathways.
However,
alterations
profile
associated
genes
biochemical
indicators
revealed
gender-specific
responses
following
exposure.
Besides,
histopathological
observations
as
well
inflammatory
response
confirmed
development
nonalcoholic
fatty
disease,
particularly
zebrafish.
Altogether,
our
findings
highlight
liver,
enhancing
metabolic-disrupting
with
Environmental Science & Technology,
Journal Year:
2023,
Volume and Issue:
57(50), P. 21405 - 21415
Published: Dec. 7, 2023
The
ubiquitous
occurrence
of
benzotriazole
ultraviolet
stabilizers
(BUVSs)
in
the
environment
and
organisms
has
warned
their
potential
ecological
health
risks.
Studies
showed
that
some
BUVSs
exerted
immune
chronic
toxicities
to
animals
by
disturbing
signaling
transduction,
yet
limited
research
investigated
toxic
effects
on
crop
plants
underlying
mechanisms
regulation.
Herein,
a
laboratory-controlled
hydroponic
experiment
was
conducted
rice
explore
phytotoxicity
integrating
conventional
biochemical
experiments,
transcriptomic
analysis,
competitive
sorption
assays,
computational
studies.
results
inhibited
growth
6.30–20.4%
excessively
opening
leaf
stomas,
resulting
increased
transpiration.
interrupted
transduction
abscisic
acid
(ABA)
signal
through
competitively
binding
Ca2+-dependent
protein
kinase
(CDPK),
weakening
CDPK
phosphorylation
further
inhibiting
downstream
signaling.
As
structural
analogues
ATP,
acted
as
ABA
antagonists,
leading
physiological
dysfunction
mediating
stomatal
closure
under
stresses.
This
is
first
comprehensive
study
elucidating
function
key
proteins
associated
providing
insightful
information
for
risk
evaluation
control
BUVSs.
Environmental Science & Technology,
Journal Year:
2023,
Volume and Issue:
58(1), P. 110 - 120
Published: Dec. 19, 2023
Benzotriazole
ultraviolet
stabilizers
(BUVSs)
are
chemicals
used
to
mitigate
UV-induced
damage
manufactured
goods.
Their
presence
in
aquatic
environments
and
biota
raises
concerns,
as
certain
BUVSs
activate
the
aryl
hydrocarbon
receptor
(AhR),
which
is
linked
adverse
effects
fish.
However,
potencies
of
AhR
agonists
species
sensitivities
activation
poorly
understood.
This
study
evaluated
toxicity
three
using
embryotoxicity
assays.
Zebrafish
(Danio
rerio)
embryos
exposed
by
microinjection
suffered
dose-dependent
increases
mortality,
with
LD50
values
4772,
11
608,
56
292
ng/g-egg
for
UV-P,
UV-9,
UV-090,
respectively.
The
AhR2
were
assessed
a
luciferase
reporter
gene
assay
COS-7
cells
transfected
zebrafish
eight
other
fishes.
rank
order
potency
from
all
nine
was
UV-P
>
UV-9
UV-090.
AhR2s
among
differed
up
100-fold.
An
approximate
reversed
sensitivity
observed
compared
2,3,7,8-tetrachlorodibenzo[p]dioxin,
prototypical
agonist.
Despite
this,
pre-existing
quantitative
outcome
pathway
linking
embryo
lethality
could
predict
embryotoxicities
zebrafish.
