Journal of Applied Toxicology,
Journal Year:
2023,
Volume and Issue:
44(4), P. 488 - 500
Published: Sept. 12, 2023
Abstract
Based
on
the
87
original
publications
only
from
quartiles
1
and
2
of
Journal
Citation
Report
(JCR)
collected
by
major
academic
databases
(Science
Direct,
Web
Science,
PubMed,
Wiley)
in
2022,
frontier
toxicology
studies
zebrafish
model
is
summarized.
Herewith,
a
total
six
aspects
covered
such
as
developmental,
neurological,
cardiovascular,
hepatic,
reproductive,
immunizing
toxicities.
The
tested
samples
involve
chemicals,
drugs,
new
environmental
pollutants,
nanomaterials,
its
derivatives,
along
with
those
related
mechanisms.
This
report
may
provide
focus
benefit
to
researchers
engaging
for
environment,
medicine,
food,
other
fields.
Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
263, P. 115374 - 115374
Published: Aug. 14, 2023
As
a
new
type
of
persistent
organic
pollutant,
perfluorooctane
sulphonate
(PFOS)
has
received
extensive
attention
worldwide.
Cannabidiol
(CBD)
is
non-psychoactive
natural
cannabinoid
extract
that
been
proved
to
have
antioxidation,
regulation
inflammation
and
other
functions.
However,
the
effects
PFOS
on
liver
injury
whether
CBD
can
alleviate
PFOS-induced
are
still
unclear.
Therefore,
in
this
study,
we
used
(10
mg/kg)
and/or
(5
intraperitoneally
inject
mice
for
30
days.
We
found
exposure
led
inflammatory
infiltration
mice,
increased
formation
macrophage
extracellular
trap
(MET),
promoted
fibrosis.
In
vitro,
established
coculture
system
RAW264.7,
AML12
LX-2
cells,
treated
them
with
μM)
(200
μM).
The
results
showed
could
also
induce
expression
MET,
fibrosis
marker
genes
vitro.
Coiled-coil
domain
containing
protein
25
(CCD25),
as
MET-DNA
sensor,
was
investigate
its
ability
regulate
fibrosis,
knocked
down
CCDC25
downstream
proteins
(integrin-linked
kinase,
ILK)
by
siRNA
technology,
QNZ
inhibit
NF-κB
pathway.
knockdown
ILK
inhibition
pathway
MET-induced
gene
expression.
summary,
MET
promote
through
CCDC25-ILK-NF-κB
signaling
axis,
while
treatment
protective
effect,
it
Macromolecular
docking
effect
achieved
combining
peptidylarginine
deiminase
4
(PAD4)
release
MET.
regulating
axis
an
innovative
option
effectively
reduce
hepatotoxicity.
Our
study
reveals
mechanism
hepatotoxicity
provides
promising
insights
into
role
process.
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(22), P. 9487 - 9499
Published: May 1, 2024
The
booming
development
of
artificial
intelligence
(AI)
has
brought
excitement
to
many
research
fields
that
could
benefit
from
its
big
data
analysis
capability
for
causative
relationship
establishment
and
knowledge
generation.
In
toxicology
studies
using
zebrafish,
the
microscopic
images
videos
illustrate
developmental
stages,
phenotypic
morphologies,
animal
behaviors
possess
great
potential
facilitate
rapid
hazard
assessment
dissection
toxicity
mechanism
environmental
pollutants.
However,
traditional
manual
observation
approach
is
both
labor-intensive
time-consuming.
this
Perspective,
we
aim
summarize
current
AI-enabled
image
video
tools
realize
full
AI.
For
analysis,
AI-based
allow
fast
objective
determination
morphological
features
extraction
quantitative
information
various
sorts.
advantages
providing
accurate
reproducible
results
while
avoiding
human
intervention
play
a
critical
role
in
speeding
up
screening
process.
enable
tracking
dynamic
changes
cellular
events
macroscopic
behaviors.
subtle
revealed
by
serve
as
sensitive
indicators
adverse
outcomes.
With
infancy,
exciting
developments
applications
are
expected
appear
years
come.
Environmental Science & Technology,
Journal Year:
2023,
Volume and Issue:
57(2), P. 1028 - 1038
Published: Jan. 3, 2023
As
alternatives
to
traditional
per-
and
polyfluoroalkyl
substances,
perfluoroalkyl
phosphonic
acids
(PFPiAs)
are
frequently
detected
in
aquatic
environments,
but
the
neurotoxic
effects
underlying
mechanisms
remain
unclear.
In
this
study,
male
zebrafish
were
exposed
6:6
PFPiA
(1
10
nM)
for
28
days,
which
exhibited
anxiety-like
symptoms.
Gut
microbiome
results
indicated
that
significantly
increased
abundance
of
Gram-negative
bacteria,
leading
enhanced
levels
lipopolysaccharide
(LPS)
inflammation
gut.
The
LPS
was
delivered
brain
through
gut–brain
axis
(GBA),
damaged
blood–brain
barrier
(BBB),
stimulated
neuroinflammation,
caused
apoptosis
as
well
neural
injury
brain.
This
mechanism
verified
by
fact
antibiotics
reduced
gut
brain,
accompanied
inflammatory
responses
behavior.
BBB
damage
also
resulted
accumulation
where
it
might
bind
strongly
with
activate
aryl
hydrocarbon
receptor
(AhR)
induce
directly.
Additionally,
fish
received
treatment
an
inhibitor
AhR,
response
behavior
decreased
distinctly.
study
sheds
light
on
new
neurotoxicity-induced
due
interruption
GBA.
Toxicological Sciences,
Journal Year:
2023,
Volume and Issue:
194(2), P. 138 - 152
Published: May 23, 2023
Abstract
The
existence
of
thousands
per-
and
polyfluoroalkyl
substances
(PFAS)
evidence
that
some
cause
adverse
health
effects
has
created
immense
need
to
better
understand
PFAS
toxicity
move
beyond
one-chemical-at-a-time
approaches
hazard
assessment
for
this
chemical
class.
zebrafish
model
enables
rapid
large
libraries
PFAS,
powerful
comparison
compounds
in
a
single
vivo
system,
evaluation
across
life
stages
generations,
led
significant
advances
research
recent
years.
focus
review
is
assess
contemporary
findings
regarding
toxicokinetics,
apical
outcomes,
potential
modes
action
using
the
model.
Much
peer-reviewed
literature
focused
on
small
subset
structural
subclasses,
such
as
perfluoroalkyl
sulfonic
acids
carboxylic
acids.
However,
data
more
diverse
structures
are
enabling
prioritization
concern.
Structure-activity
comparisons
utilization
modeling
‘omics
technologies
have
greatly
contributed
our
understanding
growing
number
will
surely
inform
predictive
capabilities
many
future.
