Small fish, big discoveries: zebrafish shed light on microbial biomarkers for neuro-immune-cardiovascular health

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: June 1, 2023

Zebrafish ( Danio rerio ) have emerged as a powerful model to study the gut microbiome in context of human conditions, including hypertension, cardiovascular disease, neurological disorders, and immune dysfunction. Here, we highlight zebrafish tool bridge gap knowledge linking physiological homeostasis cardiovascular, neural, systems, both independently an integrated axis. Drawing on studies date, discuss challenges microbiota transplant techniques gnotobiotic husbandry practices. We present advantages current limitations research use identification microbial enterotypes health disease. also versatility further explore function conditions relevant dysbiosis reveal novel therapeutic targets.

Language: Английский

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Impacts of PFOS, PFOA and their alternatives on the gut, intestinal barriers and gut-organ axis

Chemosphere, Journal Year: 2024, Volume and Issue: 361, P. 142461 - 142461

Published: May 27, 2024

Language: Английский

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Intergenerational neurotoxicity of polystyrene nanoplastics in offspring mice is mediated by dysfunctional microbe-gut-brain axis

Environment International, Journal Year: 2024, Volume and Issue: 192, P. 109026 - 109026

Published: Sept. 21, 2024

Language: Английский

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Novel Insights on 6:6 Perfluoroalkyl Phosphonic Acid-Induced Melanin Synthesis Disorders Leading to Pigmentation in Tadpoles

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(30), P. 11032 - 11042

Published: July 19, 2023

As alternatives to traditional per- and polyfluoroalkyl substances, perfluoroalkyl phosphonic acids (PFPiAs) are widely present in aquatic environments can potentially harm organisms. Pigmentation affects the probability of organisms being preyed on serves as an important toxic endpoint development, but little is known about impacts PFPiAs development In this study, Xenopus laevis embryos were exposed 6:6 PFPiA (1, 10, 100 nM) for 14 days. The developed tadpoles exhibited evident pigmentation with increased melanin particle size density skin. Pathological behavioral experiments revealed that retinal layers became thinner, reducing photosensitivity disturbing circadian rhythm tadpoles. Compared control group, showed higher levels less changes throughout light/dark cycle, well distinct oxidative damage. Consequently, expression level microphthalmia-associated transcription factor (MITF), a key inducing synthesis, significantly. Molecular docking analysis suggested forms strong interactions binding pocket MITF, implying it could activate MITF directly. activation ultimately promotes resulting

Language: Английский

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Utility of zebrafish-based models in understanding molecular mechanisms of neurotoxicity mediated by the gut–brain axis

Advances in neurotoxicology, Journal Year: 2024, Volume and Issue: unknown, P. 177 - 209

Published: Jan. 1, 2024

Language: Английский

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Coupled digital visualization and multi-omics uncover neurobehavioral dysfunction in zebrafish induced by resorcinol bis(diphenylphosphate)

Environment International, Journal Year: 2024, Volume and Issue: 192, P. 109023 - 109023

Published: Sept. 19, 2024

Language: Английский

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Enantioselective disruption of circadian rhythm behavior in goldfish (Carassius auratus) induced by chiral fungicide triadimefon at environmentally-relevant concentration

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 485, P. 136891 - 136891

Published: Dec. 15, 2024

Language: Английский

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Gut–Brain Crosstalk and the Central Mechanisms of Orofacial Pain

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(10), P. 1456 - 1456

Published: Oct. 13, 2023

Accumulated evidence has demonstrated that the gut microbiome can contribute to pain modulation through microbiome–gut–brain axis. Various relevant metabolites in are involved regulation of signaling central nervous system. In this review, we summarize recent advances gut–brain interactions by which modulate pain, with a focus on orofacial and further discuss role crosstalk mechanisms whereby modulates via vagus nerve-mediated direct pathway metabolites/molecules-mediated indirect pathway. The pathways both different brain structures (such as nucleus tractus solitarius parabrachial nucleus) transmission across blood-brain barrier, respectively. Understanding microbiome-regulated could help us develop non-opioid novel therapies for pain.

Language: Английский

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Flunitrazepam and its metabolites compromise zebrafish nervous system functionality: An integrated microbiome, metabolome, and genomic analysis

Environmental Pollution, Journal Year: 2023, Volume and Issue: 341, P. 122949 - 122949

Published: Nov. 17, 2023

Language: Английский

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Transformation of 6:6 PFPiA in the gut of Xenopus laevis: Synergistic effects of CYP450 enzymes and gut microflora

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 472, P. 134535 - 134535

Published: May 6, 2024

Language: Английский

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