Curcuma Longa-Based Green and Sustainable Antioxidants for Biopolymers DOI
Mohammad Abdul Sattar

ACS Sustainable Chemistry & Engineering, Journal Year: 2024, Volume and Issue: 12(17), P. 6494 - 6508

Published: April 12, 2024

Unsaturated biopolymers (e.g., natural rubber (NR)) are highly vulnerable to thermo-oxidative degradation, which causes premature failure of NR products. As an indispensable antioxidant globally, 6PPD (N-(1,3-dimethyl butyl)-N′-phenyl-p-phenylenediamine) is employed retard the aging NR. Unluckily, and 6PPD-quinone (an oxidative product 6PPD) harmful aquatic human life and, thus, obviously merit their replacement with sustainable safer antioxidants for environmental protection. This study explored use curcumin NR-based polymer nanocomposites (PNCs). The combined experimental, molecular dynamics (MD), quantum mechanics (QM) simulations implemented analyze effect isomeric forms on protective mechanism, stability, solubility, dispersibility, diffusion in matrix. results revealed that both scavenged free radical preferentially via a hydrogen atom transfer mechanism. computed transition state energies show curcumin's enolic form (i.e., Curcumin (E)) interacts ROO. (peroxy) radicals lower barrier energy compared could protect from aging. MD have shown interfacial interactions at NR-curcumin interface resulted stronger binding energies, thus improving solubility dispersibility mean square displacement than 6PPD. While migration necessary replenish concentrations tire surface, higher rate may cause physical loss decrease service NR-PNCs. Overall, NR-PNCs loaded exhibited improved resistance viscoelastic performance PNCs made Thus, as safe antioxidant, open essential avenue toward substantial pollution abatement accumulated waste products making "Greener NR-PNCs.″

Language: Английский

Tire-rubber related pollutant 6-PPD quinone: A review of its transformation, environmental distribution, bioavailability, and toxicity DOI
Xin Hua, Dayong Wang

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 459, P. 132265 - 132265

Published: Aug. 15, 2023

Language: Английский

Citations

82
First insights into 6PPD-quinone formation from 6PPD photodegradation in water environment DOI
Chenguang Li, Yanlei Zhang,

Shiqi Yin

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 459, P. 132127 - 132127

Published: July 23, 2023

Language: Английский

Citations

49
Synthetic Antioxidants as Contaminants of Emerging Concern in Indoor Environments: Knowns and Unknowns DOI

Xiaomeng Ji,

Jiefeng Liang,

Yingjun Wang

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(51), P. 21550 - 21557

Published: Dec. 12, 2023

Synthetic antioxidants, including synthetic phenolic antioxidants (SPAs), amine (AAs), and organophosphite (OPAs), are essential additives for preventing oxidative aging in various industrial consumer products. Increasing attention has been paid to the environmental contamination caused by these chemicals, but our understanding of is generally limited compared other emerging contaminants such as plasticizers flame retardants. Many people spend a significant portion (normally greater than 80%) their time indoors, meaning that they experience widespread persistent exposure indoor contaminants. Thus, this Perspective focuses on problem The wide application commercial products demonstrated toxicity make them an important family concern. However, knowledge gaps still need be bridged: novel related transformation identified environments, different dust sampling strategies should employed evaluate human contaminants, geographic scope research broadened, partition coefficients among media investigated.

Language: Английский

Citations

49
Polyethylene nanoparticles at environmentally relevant concentrations enhances neurotoxicity and accumulation of 6-PPD quinone in Caenorhabditis elegans DOI

Xin Hua,

Dayong Wang

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170760 - 170760

Published: Feb. 6, 2024

Language: Английский

Citations

29
Association between 6PPD-quinone exposure and BMI, influenza, and diarrhea in children DOI
Zhuxia Zhang, Xijin Xu,

Ziyi Qian

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 247, P. 118201 - 118201

Published: Jan. 21, 2024

Language: Английский

Citations

23
Environmental profiles, hazard identification, and toxicological hallmarks of emerging tire rubber-related contaminants 6PPD and 6PPD-quinone DOI Creative Commons

Yang Jiang,

Chunzhi Wang,

Ling Ma

et al.

Environment International, Journal Year: 2024, Volume and Issue: 187, P. 108677 - 108677

Published: April 21, 2024

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) is commonly used in rubber compounds as antioxidants to protect against degradation from heat, oxygen, and ozone exposure. This practice extends the lifespan of products, including tires, by preventing cracking, aging, deterioration. However, environmental consequences waste generated during product use, particularly formation 6PPD-quinone (6PPD-Q) through reaction 6PPD with ozone, have raised significant concerns due their detrimental effects on ecosystems. Extensive research has revealed widespread occurrence its derivate 6PPD-Q various compartments, air, water, soil. The emerging substance been shown pose acute mortality long-term hazards aquatic terrestrial organisms at concentrations below environmentally relevant levels. Studies demonstrated toxic a range organisms, zebrafish, nematodes, mammals. These include neurobehavioral changes, reproductive dysfunction, digestive damage exposure pathways. Mechanistic insights suggest that mitochondrial stress, DNA adduct formation, disruption lipid metabolism contribute toxicity induced 6PPD-Q. Recent findings human samples, such blood, urine, cerebrospinal fluid, underscore importance further public health toxicological implications these compounds. distribution, fate, biological effects, underlying mechanisms environment highlight urgent need for additional understand address impacts

Language: Английский

Citations

21
High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage DOI Creative Commons
Yunjia Lai, Jeremy P. Koelmel, Douglas G. Walker

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(29), P. 12784 - 12822

Published: July 10, 2024

In the modern "omics" era, measurement of human exposome is a critical missing link between genetic drivers and disease outcomes. High-resolution mass spectrometry (HRMS), routinely used in proteomics metabolomics, has emerged as leading technology to broadly profile chemical exposure agents related biomolecules for accurate measurement, high sensitivity, rapid data acquisition, increased resolution space. Non-targeted approaches are increasingly accessible, supporting shift from conventional hypothesis-driven, quantitation-centric targeted analyses toward data-driven, hypothesis-generating exposome-wide profiling. However, HRMS-based exposomics encounters unique challenges. New analytical computational infrastructures needed expand analysis coverage through streamlined, scalable, harmonized workflows pipelines that permit longitudinal tracking, retrospective validation, multi-omics integration meaningful health-oriented inferences. this article, we survey literature on state-of-the-art technologies, review current informatic pipelines, provide an up-to-date reference exposomic chemists, toxicologists, epidemiologists, care providers, stakeholders health sciences medicine. We propose efforts benchmark fit-for-purpose platforms expanding space, including gas/liquid chromatography-HRMS (GC-HRMS LC-HRMS), discuss opportunities, challenges, strategies advance burgeoning field exposome.

Language: Английский

Citations

20
UV-induced photodegradation of emerging para-phenylenediamine quinones in aqueous environment: Kinetics, products identification and toxicity assessments DOI
Wei Wang, Guodong Cao, Jing Zhang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 465, P. 133427 - 133427

Published: Jan. 5, 2024

Language: Английский

Citations

19
Sunlight-Induced Transformation of Tire Rubber Antioxidant N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) to 6PPD-Quinone in Water DOI
Yangjian Zhou,

Lacuo Yixi,

Qingqing Kong

et al.

Environmental Science & Technology Letters, Journal Year: 2023, Volume and Issue: 10(9), P. 798 - 803

Published: Aug. 15, 2023

The huge consumption of the tire rubber antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) has resulted in pervasive contamination aquatic environments. More importantly, transformation product 6PPD, i.e., 6PPD-quinone (6PPD-Q), is raising increasing concerns due to its high toxicity organisms. However, whether and how 6PPD-Q can be formed from 6PPD environments remain unknown. Herein, we reported water under sunlight irradiation elucidated underlying mechanisms. In result, was confirmed with a noteworthy molar yield ∼1.01% within 90 min at pH 7.0 simulated irradiation. experimental observations, including transient stable intermediate identification reactive species quenching, evidenced that pathways started photoexcitation followed by generation hydroxyl intermediates form 6PPD-Q. This study revealed sunlight-induced could an important origin environments, providing significant insights potentially underestimated ecological risks 6PPD.

Language: Английский

Citations

40
A mini review on 6PPD quinone: A new threat to aquaculture and fisheries DOI
Kailash Bohara, Anil Timilsina, Kaushik Adhikari

et al.

Environmental Pollution, Journal Year: 2023, Volume and Issue: 340, P. 122828 - 122828

Published: Oct. 29, 2023

Language: Английский

Citations

30