Industrial
activities
are
a
major
source
of
organophosphorus
flame
retardants
(OPFRs)
and
plasticizers
in
aquatic
environments.
This
study
investigated
the
distribution
40
OPFRs
river
impacted
by
industrial
manufacturing
plants
Eastern
China
target
analysis.
Nontarget
analysis
using
high-resolution
mass
spectrometry
was
further
employed
to
identify
novel
compounds
(NOPs).
Thirty-four
were
detected
water
samples,
with
total
concentrations
62.9–1.06
×
103
ng/L
(median:
455
ng/L).
Triphenylphosphine
oxide
diphenyl
phosphoric
acid
ubiquitously
up
620
127
ng/L,
respectively.
Among
26
identified
NOPs,
17
reported
for
first
time
environment,
including
14
organophosphate
esters
(especially
4
heterocycles
3
oligomers),
2
organophosphites,
an
organophosphonate.
Bis(2,4-di-tert-butylphenyl)
hydrogen
phosphate
2,2-dimethylpropoxy(propyl)phosphinic
high
predicted
persistence
or
toxicity
widely
detected,
semiquantified
990
1.0
Structurally
similar
exhibited
consistent
variation
trends,
suggesting
common
emission
source.
Estimated
annual
discharges
sea
20.6–37.0
kg/yr
30.8–161
NOPs.
These
findings
indicate
that
contribute
NOPs
catchment
its
estuary,
posing
ecological
risks
both
terrestrial
marine
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(14), P. 6402 - 6414
Published: March 28, 2024
Limited
knowledge
on
the
structure
of
emerging
organophosphorus
compounds
(OPCs)
hampers
our
comprehensive
understanding
their
environmental
occurrence
and
potential
risks.
Through
suspect
nontarget
screening,
combining
data-dependent
acquisition,
data-independent
parallel
reaction
monitoring
modes,
we
identified
60
OPCs
(17
traditional
43
compounds)
in
effluents
14
wastewater
treatment
plants
(WWTPs)
Beijing
Qinghai,
China.
These
comprise
26
organophosphate
triesters,
17
diesters,
6
organophosphonates,
7
organothiophosphate
esters,
4
other
OPCs.
Notably,
were
newly
WWTP
effluents,
16
discovered
matrices.
Specifically,
cyclic
phosphonate,
(5-ethyl-2-methyl-1,3,2-dioxaphosphorinan-5-yl)methyl
dimethyl
phosphonate
P-oxide
(PMMMPn),
consistently
appeared
all
with
semiquantitative
concentrations
ranging
from
44.4
to
282
ng/L.
Its
analogue,
di-PMMMPn,
presented
93%
samples.
Compositional
differences
between
two
cities
mainly
attributed
Hazard
ecological
risk
assessment
underscored
substantial
contribution
chlorinated
esters
overall
risks
effluents.
This
study
provides
most
OPC
profiles
date,
highlighting
need
for
further
research
occurrence,
fate,
risks,
particularly
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(24), P. 10740 - 10751
Published: May 21, 2024
The
contamination
status
of
novel
organophosphate
esters
(NOPEs)
and
their
precursors
organophosphite
antioxidants
(OPAs)
hydroxylated/diester
transformation
products
(OH-OPEs/di-OPEs)
in
soils
across
a
large-scale
area
China
were
investigated.
total
concentrations
the
three
test
NOPEs
soil
82.4–716
ng
g–1,
which
considerably
higher
than
those
traditional
OPEs
(4.50–430
g–1),
OPAs
(n.d.–30.8
OH-OPEs
(n.d.–0.49
di-OPEs
(0.57–21.1
g–1).
One
NOPE
compound,
i.e.,
tris(2,4-di-tert-butylphenyl)
phosphate
(AO168
=
O)
contributed
over
65%
studied
OPE-associated
contaminants.
A
30-day
incubation
experiment
was
performed
to
confirm
influence
AO168
O
on
bacterial
communities.
Specific
genera
belonging
Proteobacteria,
such
as
Lysobacter
Ensifer,
enriched
O-contaminated
soils.
Moreover,
ecological
function
methylotrophy
observed
be
significantly
enhanced
(t-test,
p
<
0.01)
treated
with
O,
while
nitrogen
fixation
inhibited
0.01).
These
findings
comprehensively
revealed
contaminants
environment
provided
first
evidence
effects
microbial
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(18), P. 7986 - 7997
Published: April 24, 2024
The
indoor
environment
is
a
typical
source
for
organophosphorus
flame
retardants
and
plasticizers
(OPFRs),
yet
the
characteristics
of
OPFRs
in
different
microenvironments
remain
less
clear.
This
study
collected
109
air
samples
34
paired
dust
from
4
within
university
Tianjin,
China,
including
dormitory,
office,
library,
information
center.
29
target
were
analyzed,
novel
compounds
(NOPs)
identified
by
fragment-based
nontarget
analysis.
Target
exhibited
highest
concentrations
46.2–234
ng/m3
20.4–76.0
μg/g,
respectively,
center,
where
chlorinated
dominant.
Triphenyl
phosphate
(TPHP)
was
primary
OPFR
office
air,
while
tris(2-chloroethyl)
dominated
dust.
TPHP
predominant
library.
Triethyl
(TEP)
ubiquitous
tris(2-butoxyethyl)
particularly
high
9
25
NOPs
first
time,
mainly
center
such
as
bis(chloropropyl)
2,3-dichloropropyl
phosphate.
Diphenyl
phosphinic
acid,
two
hydroxylated
methylated
metabolites
tris(2,4-ditert-butylphenyl)
phosphite
(AO168),
dimer
newly
reported
environment.
widely
associated
with
OPFRs,
their
human
exposure
risk
environmental
behaviors
warrant
further
study.
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(32), P. 14506 - 14517
Published: Aug. 1, 2024
With
the
development
of
large
numbers
novel
organophosphate
esters
(OPEs)
alternatives,
it
is
imperative
to
screen
and
identify
those
with
high
priority.
In
this
study,
surface
water,
biofilms,
freshwater
snails
were
collected
from
flow-in
rivers
Taihu
Lake
Basin,
China.
Screened
by
target,
suspect,
nontarget
analysis,
11
traditional
14
OPEs
identified,
which
5
first
discovered
in
Basin.
The
OPE
concentrations
water
ranged
196
2568
ng/L,
primary
homologue
tris(2,4-ditert-butylphenyl)
phosphate
(TDtBPP)
being
newly
was
likely
derived
transformation
phosphite.
majority
identified
displayed
substantially
higher
bioaccumulation
biomagnification
potentials
biofilm-snail
food
chain
than
ones.
Quantitative
structure–property
relationship
models
revealed
both
hydrophobicity
polarity
influenced
OPEs,
while
electrostatic
attraction
also
had
a
contribution
biofilm.
TDtBPP
determined
as
utmost
priority
toxicological
index
scheme,
integrated
concentration,
bioaccumulation,
biomagnification,
acute
toxicity,
endocrine
disrupting
potential
OPEs.
These
findings
provide
insights
into
behaviors
scientific
bases
for
better
management
high-risk
pollutants
aquatic
ecosystem.
Environmental Science & Technology Letters,
Journal Year:
2024,
Volume and Issue:
11(9), P. 920 - 930
Published: Aug. 13, 2024
Tris(2,4-di-tert-butylphenyl)
phosphite
(AO168)
is
a
widely
utilized
organophosphite
antioxidant
in
the
field
of
plastics.
Throughout
production
and
usage
processes,
AO168
can
undergo
oxidation
convert
into
tris(2,4-di-tert-butylphenyl)
phosphate
(AO168═O),
which
has
been
identified
as
one
novel
organophosphate
esters
(OPEs).
AO168═O
now
extensively
present
environment,
with
concentrations
generally
exceeding
those
traditional
OPEs
such
triphenyl
tri(2-chloroisopropyl)
phosphate.
Consequently,
emerged
significant
concern
that
receiving
attention
from
scientific
community.
However,
there
exists
some
controversy
regarding
formation
mechanisms
potential
risks
AO168═O.
This
Review
provides
comprehensive
overview
for
first
time
environmental
occurrence,
pathways,
toxicities,
linked
to
AO168═O,
aiming
assist
researchers
policymakers
obtaining
an
unbiased
description
its
impacts
on
both
environment
human
health.
Given
numerous
unresolved
aspects
surrounding
along
wide
greater
should
be
devoted
this
emerging
contaminant.
The
human
exposome
remains
limited
due
to
the
challenging
analytical
strategies
used
reveal
low-level
endocrine-disrupting
chemicals
(EDCs)
and
their
metabolites
in
serum
urine.
This
limits
integrity
of
EDC
exposure
assessment
hinders
understanding
cumulative
health
effects.
In
this
study,
we
propose
an
enhanced
protocol
based
on
multi-solid-phase
extraction
(multi-SPE)
expand
with
polar
EDCs
train
a
machine
learning
(ML)
model
for
methodology
prediction
molecular
descriptors.
measurement
70
(25%)
34
(12%)
out
295
well-acknowledged
urine
compared
hydrophilic–lipophilic
balance
sorbent
alone.
nontarget
analysis
from
20
women
childbearing
age
cohort
498,
controlling
occupational
factors
daily
behaviors
high
chemical
potential,
multi-SPE
increased
10
(40%)
16
(53%)
target
identification
17
(77%)
(36%)
(confidence
≥
level
3)
urine,
respectively.
Interestingly,
ML
predicted
that
could
identify
additional
38%
most
bioactive
chemicals.
conclusion,
advances
by
expanding
profiles.
