Polylactic Acid Micro/Nanoplastic Exposure Induces Male Reproductive Toxicity by Disrupting Spermatogenesis and Mitochondrial Dysfunction in Mice

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Although considered an "eco-friendly" biodegradable plastic, polylactic acid (PLA) microplastic (PLA-MP) poses a growing concern for human health, yet its effects on male reproductive function remain underexplored. This study investigated the toxicity of PLA in mice and potential mechanisms. To this end, our vivo vitro experiments demonstrated that after degradation digestive system, significant number PLA-MP-derived nanoparticles could penetrate blood–testis barrier (BTB) localize within spermatogenic microenvironment. Mice exposed to PLA-MPs long time exhibited toxicity, evidenced by decreased sperm concentration motility, increased deformity rates, disrupted sex hormone levels. Further analysis revealed impaired BTB, induced mitochondrial dysfunction testes, triggered oxidative stress through excessive ROS production from mitochondria, leading further testicular damage. Notably, nanoplastics internalized sheath structure sperm, causing dose-dependent impairments function. Transcriptome analyses indicated spermatogenesis inhibiting expression key mRNA involved process. Collectively, findings highlight toxic effect damaging BTB impairing function, which provides insights into toxicological implications microplastics mammalian fertility.

Language: Английский

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Microplastics in human skeletal tissues: Presence, distribution and health implications

Environment International, Journal Year: 2025, Volume and Issue: 196, P. 109316 - 109316

Published: Feb. 1, 2025

Although microplastics have been detected in human blood, placenta and other tissues. In this study, for the first time, we characterized presence variation of microplastic deposition patterns three skeletal tissues, namely bone, cartilage, intervertebral discs. Forty fragments were observed 24 samples from disc, ranging 25.44 to 407.39 μm diameter. The abundance disc (61.1 ± 44.2 particles/g) was higher than those bone (22.9 15.7 cartilage tissue (26.4 17.6 particles/g). average sizes discs (159.5 103.8 μm) (138.86 105.67 larger that (87.5 30.7 μm). most frequently identified polymers polypropylene (35 %), ethylene vinyl acetate copolymer (30 polystyrene (20 %). vivo experiment suggested invaded through blood circulation after 4 weeks exposure. Serum levels tumor necrosis factor-α (TNF-α), Type Ⅰ procollagen amino-terminal peptide (PINP), tartrate-resistant acid phosphatase-5b (TRACP-5b) elevated compared with control group (p < 0.05). Our study suggests invade supply, causing distinct accumulation these regions. Microplastic invasion can affect health by influencing expression inflammatory morphogenetic cytokines. These findings provide insights into investigating impact on health.

Language: Английский

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Insight into the aggregation kinetics of nanoplastics in aquatic environments: Combined effects of protein corona and particle size

Separation and Purification Technology, Journal Year: 2025, Volume and Issue: 362, P. 131899 - 131899

Published: Jan. 31, 2025

Language: Английский

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Microplastics in coastal and marine environments: A critical issue of plastic pollution on marine organisms, seafood contaminations, and human health implications

Journal of Hazardous Materials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100663 - 100663

Published: Feb. 1, 2025

Language: Английский

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First Identification of Microplastics in Human Uterine Fibroids and Myometrium

Environmental Pollution, Journal Year: 2024, Volume and Issue: 360, P. 124632 - 124632

Published: July 27, 2024

Language: Английский

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Organoids: development and applications in disease models, drug discovery, precision medicine, and regenerative medicine

MedComm, Journal Year: 2024, Volume and Issue: 5(10)

Published: Sept. 21, 2024

Organoids are miniature, highly accurate representations of organs that capture the structure and unique functions specific organs. Although field organoids has experienced exponential growth, driven by advances in artificial intelligence, gene editing, bioinstrumentation, a comprehensive overview organoid applications remains necessary. This review offers detailed exploration historical origins characteristics various types, their applications-including disease modeling, drug toxicity efficacy assessments, precision medicine, regenerative medicine-as well as current challenges future directions research. have proven instrumental elucidating genetic cell fate hereditary diseases, infectious metabolic disorders, malignancies, study processes such embryonic development, molecular mechanisms, host-microbe interactions. Furthermore, integration technology with intelligence microfluidics significantly advanced large-scale, rapid, cost-effective thereby propelling progress medicine. Finally, advent high-performance materials, three-dimensional printing technology, also gaining prominence Our insights predictions aim to provide valuable guidance researchers support continued advancement this rapidly developing field.

Language: Английский

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From insects to mammals! Tissue accumulation and transgenerational transfer of micro/nano-plastics through the food chain

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136424 - 136424

Published: Nov. 8, 2024

Language: Английский

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The impact of microplastics on the efficacy of urban wastewater treatment processes

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(5), P. 113625 - 113625

Published: July 20, 2024

Language: Английский

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Microplastics on the Planet: Current Knowledge and Challenges

Environmental Science & Technology Letters, Journal Year: 2024, Volume and Issue: 11(12), P. 1262 - 1271

Published: Nov. 25, 2024

Microplastic (MP) pollution has become a global issue, attracting attention from stakeholders around the globe. Knowledge of MPs been substantially advanced in recent years. Newly developed analytical technologies allow better characterization MPs, but characterizing nanosized plastic particles remains challenging. Transport debris land to oceans is key driver for marine pollution, and relative contributions riverine runoff atmospheric deposition must be further quantified. Another lingering issue whether can bioaccumulate biomagnify along food web, which demands investigations. Currently there no health risk assessment human exposure probably due lack reference threshold values. Hence, establishing values should long-term continuing task scientific community. Recent progress quantifying vertical settling deep brightened prospect finding "Missing Plastics", at least partially. Future efforts are urgently needed developing novel techniques, conducting additional laboratory field measurements, formulating robust models understand occurrence, fate, effects on planet.

Language: Английский

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Unveiling the Heart’s Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip

ACS Nano, Journal Year: 2024, Volume and Issue: 18(45), P. 31569 - 31585

Published: Nov. 1, 2024

Exposure to micro- and nanoplastics (MNPs) has been implicated in potential cardiotoxicity. However, vitro models based on cardiomyocyte cell lines lack crucial cardiac characteristics, while interspecies differences animal compromise the reliability of conclusions. In addition, current research predominantly focused single-time point exposures MNPs, neglecting comparative analyses injury across early late stages. Moreover, there remains a large gap understanding susceptibility MNPs under pathological conditions. To address these limitations, this study integrated organoids (COs) organ-on-a-chip (OoC) technology develop organoid-on-a-chip (COoC), which was validated for cardiotoxicity evaluation through multiple dimensions. Based COoC, we conducted dynamic observation damage caused by short- long-term exposure polystyrene (PS-NPs). Oxidative stress, inflammation, disruption calcium ion homeostasis, mitochondrial dysfunction were confirmed as mechanisms PS-NP-induced events stages, fibrosis emerged prominent feature Notably, low-dose exacerbated myocardial infarction symptoms states, despite no significant shown healthy models. conclusion, findings further deepened our cardiotoxic effects introduced promising platform assessing

Language: Английский

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