Environmental Toxicology,
Journal Year:
2019,
Volume and Issue:
34(4), P. 486 - 494
Published: Jan. 4, 2019
Macrophages
not
only
play
an
important
role
in
the
innate
immune
response
but
also
participate
many
inflammatory
and
infectious
diseases
including
asthma,
diabetes,
obesity,
cardiovascular
diseases,
cancers.
Bisphenol
A
(BPA)
is
most
commonly
used
component
for
plastic
products.
However,
BPA
endocrine
disruptor
mammals
participates
several
diseases.
Up
until
now,
there
are
no
researches
demonstrated
potential
of
macrophage
activation
its
relative
mechanism.
promoted
generation
proinflammatory
cytokines
IL-1β,
IL-6,
TNFα
a
concentration-dependent
manner
(P
<
0.05).
was
identified
to
increase
expression
mediators
NO
PGE2,
upstream
factors
iNOS,
COX2,
cPLA2
Phosphorylation
nuclear
translocation
NF-κB
p65
were
significantly
induced
by
via
IκB
degradation
In
addition,
phosphorylation
ERK
at
concentration
which
less
than
that
p38
MAPK
JNK
Furthermore,
STAT3
lower
STAT1
JAK1
JAK2
Environmental Science & Technology,
Journal Year:
2018,
Volume and Issue:
52(11), P. 6617 - 6625
Published: May 15, 2018
Bisphenol
S
(4-hydroxyphenyl
sulfone,
BPS)
is
increasingly
used
as
a
bisphenol
A
(BPA)
alternative.
The
global
usage
of
BPS
and
its
analogues
(BPSs)
resulted
in
the
frequent
detection
their
residues
multiple
environmental
media.
We
investigated
potential
endocrine-disrupting
effects
toward
thyroid
hormone
receptor
(TR)
β.
molecular
interaction
BPSs
TRβ
ligand
binding
domain
(LBD)
was
probed
by
fluorescence
spectroscopy
dynamics
(MD)
simulations.
caused
static
quenching
LBD.
100
ns
MD
simulations
revealed
that
significant
changes
distance
between
residue
His435
at
helix
11(H11)
Phe459
H12
comparison
to
no
ligand-bound
LBD,
indicating
relative
repositioning
H12.
recombinant
two-hybrid
yeast
assay
showed
tetrabromobisphenol
(TBBPS)
(TBBPA)
have
potent
antagonistic
activity
TRβ,
with
an
IC10
10.1
21.1
nM,
respectively.
BPA
312
884
significantly
altered
expression
level
mRNA
gene
zebrafish
embryos.
TBBPS
environmentally
relevant
concentrations
implying
are
not
safe
alternatives
many
BPA-free
products.
Future
health
risk
assessments
for
TR
disruption
other
adverse
should
focus
more
on
structure–activity
relationship
design
benign
alternatives.
Toxicology and Industrial Health,
Journal Year:
2019,
Volume and Issue:
35(4), P. 294 - 303
Published: March 14, 2019
Bisphenol
A
(BPA)
is
a
well-known
endocrine-disrupting
chemical
with
estrogenic
activity.
The
widespread
exposure
of
individuals
to
BPA
suspected
affect
variety
physiological
functions,
including
reproduction,
development,
and
metabolism.
Here
we
report
the
mechanisms
by
which
three
its
analogues
bisphenol
B
(BPB),
F
(BPF),
S
(BPS)
cause
generation
reactive
oxygen
species
(ROS),
sperm
DNA
damage,
oxidative
stress
in
both
vivo
vitro
rat
models.
Sperm
were
incubated
different
concentrations
(1,
10,
100
µg/L)
BPB,
BPF,
BPS
for
2
h.
observed
increase
fragmentation,
formation
ROS,
affected
levels
superoxide
dismutase
at
higher
concentration
groups.
In
an
experiment,
rats
exposed
(5,
25,
50
mg/kg/day)
BPA,
28
days.
dose
(50
treated
groups
BPS,
damage
was
while
motility
not
affected.
Environmental Science & Technology,
Journal Year:
2020,
Volume and Issue:
54(6), P. 3476 - 3486
Published: Feb. 24, 2020
In
this
study,
a
set
of
15
bisphenols
(BPs)
and
one
emerging
derivative
(4-hydroxyphenyl
4-isoprooxyphenylsulfone,
BPSIP)
were
analyzed
in
60
pairs
maternal
plasma,
cord
placenta
samples
from
pregnant
women
South
China.
A
total
4
the
target
BPs,
i.e.,
BPA,
bisphenol
S
(BPS),
AF
(BPAF),
E
(BPE),
frequently
detected
three
human
biological
matrixes.
The
BPSIP
was
identified
all
plasma
at
unexpectedly
high
levels,
second
only
to
BPA.
concentrations
slightly
higher
than
for
BPS,
BPE
but
much
lower
BPAF,
indicating
that
five
have
different
placental
transfer
behaviors.
efficiencies
(PTEs)
similar,
which
significantly
PTE
BPSIP.
BPAF
other
its
strong
fetal
accumulation.
PTEs
structure-dependent,
passive
diffusion
suggested
as
potential
mechanism
transfer.
Significant
concentration
correlations
major
between
observed
(p
<
0.05).
Meanwhile,
significant
associations
maternal/cord
with
some
characteristics
adverse
birth
outcomes
also
Environmental Science and Pollution Research,
Journal Year:
2020,
Volume and Issue:
27(32), P. 39958 - 39976
Published: Aug. 15, 2020
Abstract
Endocrine-disrupting
chemicals
(EDC)
are
a
wide
group
of
that
interfere
with
the
endocrine
system.
Their
similarity
to
natural
steroid
hormones
makes
them
able
attach
hormone
receptors,
thereby
causing
unfavorable
health
effects.
Among
EDC,
bisphenol
A
(BPA),
S
(BPS),
and
nonylphenol
(NP)
seem
be
particularly
harmful.
As
industry
is
experiencing
rapid
expansion,
BPA,
BPS,
NP
being
produced
in
growing
amounts,
generating
considerable
environmental
pollution.
White
rot
fungi
(WRF)
an
economical,
ecologically
friendly,
socially
acceptable
way
remove
EDC
contamination
from
ecosystems.
WRF
secrete
extracellular
ligninolytic
enzymes
such
as
laccase,
manganese
peroxidase,
lignin
versatile
involved
deterioration.
Owing
broad
substrate
specificity
these
enzymes,
they
numerous
xenobiotics,
including
EDC.
Therefore,
promising
tool
abovementioned
elimination
during
wastewater
treatment
processes.
Here,
we
review
application
for
this
removal
indicate
several
strengths
limitations
methods.
