Effects of DNA Damage and Oxidative Stress in Human Bronchial Epithelial Cells Exposed to PM2.5 from Beijing, China, in Winter DOI Open Access

Bingyu Niu,

Wenke Li, Jiangshuai Li

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(13), P. 4874 - 4874

Published: July 6, 2020

Epidemiological studies have corroborated that respiratory diseases, including lung cancer, are related to fine particulate matter (<2.5 μm) (PM2.5) exposure. The toxic responses of PM2.5 greatly influenced by the source PM2.5. However, effects from Beijing on bronchial genotoxicity scarce. In present study, was sampled and applied in vitro investigate its mechanisms behind it. Human epithelial cells 16HBE were used as a model for Low (67.5 μg/mL), medium (116.9 high (202.5 μg/mL) doses cell After exposure, viability, oxidative stress markers, DNA (deoxyribonucleic acid) strand breaks, 8-OH-dG levels, micronuclei formation, repair gene expression measured. results showed significantly induced cytotoxicity 16HBE. Moreover, levels reactive oxygen species (ROS), malondialdehyde (MDA), cellular heme oxygenase (HO-1) increased, level glutathione (GSH) decreased, which represented occurrence severe micronucleus rate elevated, damage occurred indicators comet assay, γ-H2AX 8-OH-dG, markedly enhanced PM2.5, accompanied influence 8-oxoguanine glycosylase (OGG1), X-ray cross-complementing 1 (XRCC1), poly (ADP-ribose) polymerase-1 (PARP1) expression. These support significant role cells, may occur through combined effect genes.

Language: Английский

Air pollution: a global problem needs local fixes DOI
Xiangdong Li, Ling Jin, Haidong Kan

et al.

Nature, Journal Year: 2019, Volume and Issue: 570(7762), P. 437 - 439

Published: June 1, 2019

Language: Английский

Citations

276
Road dust resuspension: A review DOI
Ismael Casotti Rienda, Célia Alves

Atmospheric Research, Journal Year: 2021, Volume and Issue: 261, P. 105740 - 105740

Published: June 24, 2021

Language: Английский

Citations

127
Toxic potency-adjusted control of air pollution for solid fuel combustion DOI Creative Commons
Di Wu, Haotian Zheng, Qing Li

et al.

Nature Energy, Journal Year: 2022, Volume and Issue: 7(2), P. 194 - 202

Published: Jan. 6, 2022

Abstract The combustion of solid fuels, including coal and biomass, is a main anthropogenic source atmospheric particulate matter (PM). hidden costs have been underestimated due to lack consideration the toxicity PM. Here we report unequal inhalable PM emitted from energy use in residential sector coal-fired power plants (CFPPs). incomplete burning fuels household stoves generates much higher concentrations carbonaceous matter, resulting more than one order magnitude greater that CFPPs. When compared with CFPPs, consumed only tenth mainland China 2017, but it contributed about 200-fold population-weighted toxic potency-adjusted 2.5 exposure risk. We suggest -related should be considered when making air pollution emission control strategies, sources receive policy attention reduce risks.

Language: Английский

Citations

117
Biomarkers for the adverse effects on respiratory system health associated with atmospheric particulate matter exposure DOI
Caixia Guo,

Songqing Lv,

Yufan Liu

et al.

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 421, P. 126760 - 126760

Published: July 27, 2021

Language: Английский

Citations

105
The Role of Fossil Fuel Combustion Metals in PM2.5 Air Pollution Health Associations DOI Creative Commons

Polina Maciejczyk,

Lung‐Chi Chen, George Thurston

et al.

Atmosphere, Journal Year: 2021, Volume and Issue: 12(9), P. 1086 - 1086

Published: Aug. 24, 2021

In this review, we elucidate the central role played by fossil fuel combustion in health-related effects that have been associated with inhalation of ambient fine particulate matter (PM2.5). We especially focus on individual properties and concentrations metals commonly found PM air pollution, as well their sources adverse health effects, based both epidemiologic toxicological evidence. It is known transition metals, such Ni, V, Fe, Cu, are highly capable participating redox reactions produce oxidative stress. Therefore, particles enriched, per unit mass, these those from combustion, can greater potential to than other matter. Moreover, also contain varying amounts sulfur, acidic nature resulting sulfur compounds (e.g., ammonium sulfate, bisulfate, or sulfuric acid) makes more bioavailable, greatly enhancing PM2.5 cause stress systemic human body. general, there a need further recognize pollution mass complex source-driven mixture, order effectively quantify regulate particle exposure risks.

Language: Английский

Citations

104
Advances in particulate matter filtration: Materials, performance, and application DOI Creative Commons

Xuzheng Ji,

Jianying Huang, Lin Teng

et al.

Green Energy & Environment, Journal Year: 2022, Volume and Issue: 8(3), P. 673 - 697

Published: April 6, 2022

Air-borne pollutants in particulate matter (PM) form, produced either physically during industrial processes or certain biological routes, have posed a great threat to human health. Particularly the current COVID-19 pandemic, effective filtration of virus is an urgent worldwide. In this review, we first introduce some fundamentals about PM, including its source and classification, mechanisms, evaluation parameters. Advanced materials their functions are then summarized, among which polymers MOFs discussed detail together with antibacterial performance. The discussion on application divided into end-of-pipe treatment control. Finally, conclude review our prospective view future research area.

Language: Английский

Citations

93
Toxicological Effects of Fine Particulate Matter (PM2.5): Health Risks and Associated Systemic Injuries—Systematic Review DOI Open Access

Amanda Garcia,

Eduarda Santa-Helena, Anna De Falco

et al.

Water Air & Soil Pollution, Journal Year: 2023, Volume and Issue: 234(6)

Published: May 24, 2023

Language: Английский

Citations

71
Achieving health-oriented air pollution control requires integrating unequal toxicities of industrial particles DOI Creative Commons
Di Wu, Haotian Zheng, Qing Li

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 14, 2023

Protecting human health from fine particulate matter (PM) pollution is the ambitious goal of clean air actions, but current control strategies largely ignore role source-specific PM toxicity. Here, we proposed health-oriented by integrating unequal toxic potencies most polluting industrial PMs. Iron and steel industry (ISI)-emitted PM2.5 exhibit about one order magnitude higher potency than those cement power industries. Compared with mass-based strategy (prioritizing implementation ultralow emission standards in sector), (priority ISI sector) could generate 5.4 times reduction population-weighted potency-adjusted exposure among industries China. Furthermore, marginal abatement cost per unit mass ISI-emitted only a quarter that other two sectors under scenarios. We highlight urgently required to achieve cost-effective reductions risks.

Language: Английский

Citations

43
Oxidative Potential of Water-Soluble Matter Associated with Chromophoric Substances in PM2.5 over Xi’an, China DOI
Qingcai Chen,

Mamin Wang,

Yuqin Wang

et al.

Environmental Science & Technology, Journal Year: 2019, Volume and Issue: 53(15), P. 8574 - 8584

Published: June 28, 2019

Organic compounds are important contributors to the oxidative potential (OP) of atmospheric aerosols. This study is first report OP water-soluble organic matter (WSOM) related chromophoric substances in PM2.5 over Xi'an, China. The dithiothreitol (DTT) activity levels extracted by water were quantified as well relationships between DTT and light absorption fluorescence properties. results show that has significantly correlated with colored WSOM, which we identified three absorbing (BrC1-3) eight fluorescent (C1-8). It further found BrC3 C7 accounted for almost all although these two factors contributed only a small fraction fluorescence. clearly distinguished from other because their long wavelength (λmax = 475 nm) emission 462 nm), respectively. discovery will help better interpret understand mechanism oxidation generation aerosols provide guidance predicting OPs based on optical

Language: Английский

Citations

122
Environmental Exposures and Asthma Development: Autophagy, Mitophagy, and Cellular Senescence DOI Creative Commons
Karan Sachdeva, C. Danh, Yan Zhang

et al.

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: Nov. 29, 2019

EEnvironmental pollutants and allergens induce oxidative stress mitochondrial dysfunction, leading to key features of allergic asthma. Dysregulations in autophagy, mitophagy, cellular senescence have been associated with environmental pollutant allergen-induced stress, secretion multiple inflammatory proteins, subsequently development Particularly, particulate matter 2.5 (PM2.5) has reported autophagy the bronchial epithelial cells through activation AMP-activated protein kinase (AMPK), drive mitophagy activating PTEN-induced 1(PINK1)/Parkin pathway, cell cycle arrest senescence. Intriguingly, allergens, including ovalbumin (OVA), alternaria alternata, cockroach allergen, also shown different signaling pathways. Additionally, dysfunction can due excessive ROS production, which affects airway diseases. Although share similar properties, recent studies suggest that either accelerate or prevent Thus, this review, we evaluated literature regarding basic processes, senescence, explored their molecular mechanisms regulation initiation downstream signaling. Especially, highlighted involvement pollutant/allergen-induced major phenotypic changes asthma such as inflammation remodelling reviewed novel critical research areas for future studies. Ultimately, understanding regulatory may allow new therapeutic targets

Language: Английский

Citations

112