Insight into the binding model of per- and polyfluoroalkyl substances to proteins and membranes

Environment International, Journal Year: 2023, Volume and Issue: 175, P. 107951 - 107951

Published: April 27, 2023

Legacy per- and polyfluoroalkyl substances (PFASs) have elicited much concern because of their ubiquitous distribution in the environment potential hazards they pose to wildlife human health. Although an increasing number effective PFAS alternatives are available market, these bring new challenges. This paper comprehensively reviews how PFASs bind transport proteins (e.g., serum albumin, liver fatty acid organic transporters), nuclear receptors peroxisome proliferator activated receptors, thyroid hormone reproductive receptors) membranes cell membrane mitochondrial membrane). Briefly, hydrophobic fluorinated carbon chains occupy binding cavities target proteins, groups form hydrogen bonds with amino residues. Various structural features such as chlorine atom substitution, oxygen insertion a branched structure, introduce variations chain length hydrophobicity, which potentially change affinity for endogenous proteins. The toxic effects mechanisms action legacy can be demonstrated compared using models. In future studies, vitro experiments silico quantitative structure-activity relationship modeling should better integrated allow more reliable toxicity predictions both alternative PFASs.

Language: Английский

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Integration of target, suspect, and nontarget screening with risk modeling for per- and polyfluoroalkyl substances prioritization in surface waters

Water Research, Journal Year: 2023, Volume and Issue: 233, P. 119735 - 119735

Published: Feb. 12, 2023

Language: Английский

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Per- and Polyfluoroalkyl Substances and Female Health Concern: Gender-based Accumulation Differences, Adverse Outcomes, and Mechanisms

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

The deleterious health implications of perfluoroalkyl and polyfluoroalkyl substances (PFAS) are widely recognized. Females, in contrast to males, exhibit unique pathways for PFAS exposure excretion, leading complex outcomes. status females is largely influenced by hormone-related processes. have been reported be associated with various aspects female health, including reproductive system disorders pregnancy-related diseases. In this article, we provide insights into the correlations between female-prevalent Current epidemiological toxicological evidence has demonstrated that adverse effects on primarily attributed disruption hypothalamic-pituitary-gonadal (HPG) axis hormonal homeostasis. However, these findings do not sufficiently elucidate intricate associations specific Furthermore, autoimmune disorders, another category more prevalent women compared men, require additional investigation. Immune biomarkers pertinent observed exposure, although insufficient substantiate relations. Further thorough exploration encompassing studies essential elucidating inherent influence human pathologies. Additionally, comprehensive investigations issues beyond their functions essential.

Language: Английский

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Polystyrene microplastics decrease F–53B bioaccumulation but induce inflammatory stress in larval zebrafish

Chemosphere, Journal Year: 2020, Volume and Issue: 255, P. 127040 - 127040

Published: May 11, 2020

Language: Английский

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Novel and legacy poly- and perfluoroalkyl substances (PFASs) in indoor dust from urban, industrial, and e-waste dismantling areas: The emergence of PFAS alternatives in China

Environmental Pollution, Journal Year: 2020, Volume and Issue: 263, P. 114461 - 114461

Published: March 31, 2020

Language: Английский

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Developmental toxicity of the novel PFOS alternative OBS in developing zebrafish: An emphasis on cilia disruption

Journal of Hazardous Materials, Journal Year: 2020, Volume and Issue: 409, P. 124491 - 124491

Published: Nov. 5, 2020

Language: Английский

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Bioaccumulation, Biodistribution, Toxicology and Biomonitoring of Organofluorine Compounds in Aquatic Organisms

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(12), P. 6276 - 6276

Published: June 11, 2021

This review is a survey of recent advances in studies concerning the impact poly- and perfluorinated organic compounds aquatic organisms. After brief introduction on (PFCs) features, an overview monitoring reported illustrating ranges recorded concentrations water, sediments, species. Besides presenting general concepts defining bioaccumulative potential its indicators, biodistribution PFCs described taking consideration different tissues/organs investigated species as well differences between wild or under controlled laboratory conditions. The use bioindicators for biomonitoring are discussed data summarized table reporting number monitored their total concentration function Moreover, biomolecular effects taxonomically illustrated. In final paragraph, main findings have been possible solutions to environmental threats posed by environment discussed.

Language: Английский

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Comparative chronic toxicities of PFOS and its novel alternatives on the immune system associated with intestinal microbiota dysbiosis in adult zebrafish

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 425, P. 127950 - 127950

Published: Dec. 2, 2021

Language: Английский

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A review of omics-based PFAS exposure studies reveals common biochemical response pathways

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 845, P. 157255 - 157255

Published: July 8, 2022

Per and Polyfluoroalkyl Substances (PFAS) are a diverse group of man-made chemicals with range industrial applications which widespread in the environment. They structurally but comprise common chemical feature at least one (though usually more) perfluorocarbon moiety (-CnF2n-) attached to functional such as carboxylic or sulphonic acid. The strength Carbon-Fluorine bond means compounds do not break down easily can thus bioaccumulate. PFAS high concern regulators public due their potential toxicity persistence. At exposure levels, have been implicated harmful effects on human environmental health, particularly problems in/with development, cholesterol endocrine disruption, immune system function, oncogenesis. However, most toxicology studies use far higher levels than generally found Additionally, since type exposure, used, organisms tested all vary between studies, so results. Traditional ecotoxicology may identify environmentally relevant exposures. Here we conduct review omics-based using laboratory ecotoxicological methodologies show that biochemical response pathways identified multiple studies. A major pathway was pentose phosphate shunt pathway. Such molecular markers sublethal will greatly benefit accurate effective risk assessments ensure new regulations consider full health receptors.

Language: Английский

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Legacy and Emerging Poly- and Perfluoroalkyl Substances in Finless Porpoises from East China Sea: Temporal Trends and Tissue-Specific Accumulation

Environmental Science & Technology, Journal Year: 2021, Volume and Issue: 56(10), P. 6113 - 6122

Published: April 14, 2021

Perfluoroalkyl sulfonates (PFSAs), perfluoroalkyl carboxylates (PFCAs), and emerging alternatives precursors of these compounds were determined in tissues finless porpoise (Neophocaena asiaeorientalis sunameri) collected from East China Sea 2009-2010 2018-2019. The median hepatic concentrations poly- substances (PFASs), including 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA), 8:2 (8:2 2,3,3,3-tetrafluoro-2-propanoate (HFPO-DA), 4,8-dioxa-3H-perfluorononanoate (ADONA) 16.2, 2.16, < LOQ (limit quantification) ng/g ww (wet weight), respectively. legacy substances, perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), 86.9 1.95 ww, liver Cl-PFESA, HFPO-DA, perfluorohexanesulfonate (PFHxS) increased with time between Further, PFOA showed a declining trend porpoise, whereas PFOS its precursor (i.e., perfluorooctane sulfonamide [FOSA]) an increasing Analysis PFASs nine different tissues/organs liver, heart, intestine, spleen, kidney, stomach, lung, muscle, skin) revealed similar distribution pattern Cl-PFESA PFOS; however, the tissue patterns differed HFPO-DA PFOA. PFAS kidney or lower than prototype ≈ PFOA), implying slow renal excretion as that PFASs. estimates body burdens porpoises suggested comparable accumulation PFSAs PFCAs. This study provides novel information on temporal trends marine mammals China.

Language: Английский

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