Yerba Mate (Ilex paraguariensis St. Hill.) Tea May Have Cardiometabolic Beneficial Effects in Healthy and At‐Risk Subjects: A Randomized, Controlled, Blind, Crossover Trial in Nonhabitual Consumers DOI Creative Commons
Laura Bravo, Sara Martínez‐López, José Luis Sierra-Cinos

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

ABSTRACT Yerba mate has been reported to have antihypertensive, hypocholesterolemic, antidiabetic, or antiobesity properties. Most evidences from human trials involved intakes of high amounts by habitual consumers. Considering its increasing popularity, this study aimed at assessing the potential cardiometabolic effects moderate intake yerba nonhabitual A randomized, crossover, controlled was carried out in healthy and hypercholesterolemic subjects. Anthropometric parameters, blood pressure, lipids, glucose metabolism, inflammatory cytokines, chemokines, different markers endothelial function, as well incretins, adipocytokines, hormones were measured baseline after 8 weeks consuming a decaffeinated isotonic drink (control). After daily consumption three servings tea, colony‐stimulating factors decreased all participants. LDL‐C normocholesterolemic individuals, while control interventions elicited similar hypolipidemic action group. Ghrelin glucose‐dependent insulinotropic polypeptide (GIP) significantly intake, glucagon‐like peptide 1 (GLP‐1) adipocytokines remained unchanged. Body fat percentage tricipital skinfold only subjects, with no on total body weight. In conclusion, could exert protective consumers subjects cardiovascular risk. Trial Registration : This trial retrospectively registered ClinicalTrials (NCT06729905)

Language: Английский

Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension DOI Creative Commons
Fadi J. Charchar, Priscilla R. Prestes, Charlotte Mills

et al.

Journal of Hypertension, Journal Year: 2023, Volume and Issue: 42(1), P. 23 - 49

Published: Sept. 12, 2023

Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic (DBP) at least 90 (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. is associated with increased risk cardiovascular disease (CVD) events (e.g. coronary heart disease, failure and stroke) death. An international panel experts convened by the International College Experts compiled lifestyle management recommendations first-line strategy to prevent control hypertension in adulthood. We also recommend that changes be continued even when pressure-lowering medications are prescribed. Specific based on literature evidence summarized advice start these measures early life, including maintaining a healthy body weight, levels different types physical activity, eating drinking, avoidance cessation smoking alcohol use, stress sleep levels. discuss relevance specific approaches consumption sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting well integrated strategies implement using, for example, behaviour change-related technologies digital tools.

Language: Английский

Citations

94
Coffee Chlorogenic Acids Incorporation for Bioactivity Enhancement of Foods: A Review DOI Creative Commons

Alexis Rojas-González,

Claudia Yuritzi Figueroa-Hernández, Oscar González‐Ríos

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(11), P. 3400 - 3400

Published: May 25, 2022

The demand of foods with high antioxidant capacity have increased and research on these continues to grow. This review is focused chlorogenic acids (CGAs) from green coffee, which the most abundant source. main CGA in coffee 5-O-caffeoylquinic acid (5-CQA). Coffee extracts are currently widely used source enhance activity foods. Due solubility CGAs, their extraction mainly performed organic solvents. CGAs been associated health benefits, such as antioxidant, antiviral, antibacterial, anticancer, anti-inflammatory activity, others that reduce risk cardiovascular diseases, type 2 diabetes, Alzheimer’s disease. However, biological activities depend stability sensitive pH, temperature, light. 5-CQA attributed reducing proinflammatory cytokines. can negatively affect colon microbiota. An increase anthocyanins was observed when were added different food matrices dairy products, drinks, chocolate, bakery products. fortification has potential improve functionality

Language: Английский

Citations

75
Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials DOI Open Access
Vi Nguyen,

Elaine G. Taine,

Dehao Meng

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 924 - 924

Published: March 23, 2024

Chlorogenic acid (CGA) is a type of polyphenol compound found in rich concentrations many plants such as green coffee beans. As an active natural substance, CGA exerts diverse therapeutic effects response to variety pathological challenges, particularly conditions associated with chronic metabolic diseases and age-related disorders. It shows multidimensional functions, including neuroprotection for neurodegenerative disorders diabetic peripheral neuropathy, anti-inflammation, anti-oxidation, anti-pathogens, mitigation cardiovascular disorders, skin diseases, diabetes mellitus, liver kidney injuries, anti-tumor activities. Mechanistically, its integrative functions act through the modulation anti-inflammation/oxidation homeostasis. can thwart inflammatory constituents at multiple levels curtailing NF-kB pathways neutralize primitive factors, hindering propagation, alleviating inflammation-related tissue injury. concurrently raises pivotal antioxidants by activating Nrf2 pathway, thus scavenging excessive cellular free radicals. elevates AMPK maintenance restoration homeostasis glucose lipids. Additionally, neuromodulation targeting neuroreceptors ion channels. In this review, we systematically recapitulate CGA’s pharmacological activities, medicinal properties, mechanistic actions potential agent. Further studies defining specific molecules, improving bioavailability, validating clinical efficacy are required corroborate CGA.

Language: Английский

Citations

68
The Chemopreventive Effects of Chlorogenic Acids, Phenolic Compounds in Coffee, against Inflammation, Cancer, and Neurological Diseases DOI Creative Commons
Toshiyuki Murai, Satoru Matsuda

Molecules, Journal Year: 2023, Volume and Issue: 28(5), P. 2381 - 2381

Published: March 4, 2023

Coffee is one of the most widely consumed beverages, which has several effects on human body. In particular, current evidence suggests that coffee consumption associated with a reduced risk inflammation, various types cancers, and certain neurodegenerative diseases. Among constituents coffee, phenolic phytochemicals, more specifically chlorogenic acids, are abundant, there have been many attempts to utilize acid for cancer prevention therapy. Due its beneficial biological effect body, regarded as functional food. this review article, we summarize recent advances knowledge association phytochemicals contained in nutraceuticals, particular focus compounds, their intake, nutritional biomarkers, reduction disease risk, including cancer, neurological

Language: Английский

Citations

53
Blueberries in focus: Exploring the phytochemical potentials and therapeutic applications DOI Creative Commons
Sumel Ashique, Tuhin Mukherjee, Satyajit Mohanty

et al.

Journal of Agriculture and Food Research, Journal Year: 2024, Volume and Issue: 18, P. 101300 - 101300

Published: July 19, 2024

Language: Английский

Citations

16
Current Advances in Naturally Occurring Caffeoylquinic Acids: Structure, Bioactivity, and Synthesis DOI
Wenwu Liu, Jingda Li, Xuemei Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2020, Volume and Issue: 68(39), P. 10489 - 10516

Published: Aug. 26, 2020

Caffeoylquinic acids (CQAs) are a broad class of secondary metabolites that have been found in edible and medicinal plants from various families. It has 100 years since the discovery chlorogenic acid 1920. In recent years, number naturally derived CQAs isolated structurally elucidated. Accumulated evidence demonstrate wide range biological activities, such as antioxidation, antibacterial, antiparasitic, neuroprotective, anti-inflammatory, anticancer, antiviral, antidiabetic effects. Up to date, some meaningful progresses on biosynthesis total synthesis also made. Therefore, it is necessary comprehensively summarize structure, activity, biosynthesis, chemical CQAs. This review provides extensive coverage occurring discovered 1990 until 2020. Modern isolation techniques, data (including synthesis), bioactivity summarized. would be helpful for further research potential pharmaceutical agents.

Language: Английский

Citations

106
Chlorogenic Acid: A Dietary Phenolic Acid with Promising Pharmacotherapeutic Potential DOI
Amit Kumar Singh, Rajeev K. Singla, Abhay K. Pandey

et al.

Current Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 30(34), P. 3905 - 3926

Published: Aug. 17, 2022

Phenolic acids are now receiving a great deal of interest as pervasive human dietary constituents that have various therapeutic applications against chronic and age-related diseases. One such phenolic acid is being utilized in traditional medicine chlorogenic (CGA). It one the most readily available phytochemicals can be isolated from leaves fruits plants, coffee beans (Coffea arabica L.), apples (Malus spp.), artichoke (Cynara cardunculus carrots (Daucus carota betel (Piper betle burdock (Arctium etc. Despite its low oral bioavailability (about 33%), CGA has drawn considerable attention due to wide range biological activities numerous molecular targets. Several studies reported antioxidant anti-inflammatory potentials mainly account for broad-spectrum pharmacological attributes. been implicated exerting beneficial role dysbiosis by encouraging growth GUT microbes. At biochemical level, action mediated free radical scavenging efficacy, modulation glucose lipid metabolism, down-regulation pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), IL-1β, interferon-gamma (IFN-γ), upregulation nuclear factor erythroid 2-related 2 (Nrf-2), inhibition activity factor- κβ (NF-κβ), thus helping management diabetes, cardiovascular diseases, neurodegenerative disorders, cancer, hypertension This review highlights natural sources CGA, bioavailability, pharmacotherapeutic potential, underlying mechanisms clinical usefulness health disorders.

Language: Английский

Citations

59
Covalent interaction of soy protein isolate and chlorogenic acid: Effect on protein structure and functional properties DOI Creative Commons

Jiahui Shi,

Yifan Cui,

Guowei Zhou

et al.

LWT, Journal Year: 2022, Volume and Issue: 170, P. 114081 - 114081

Published: Oct. 10, 2022

Covalent interaction of soy protein isolate (SPI) and chlorogenic acid (CA) through laccase catalysis was studied. The structure, interfacial properties (foaming emulsifying properties) antioxidant activities isolate-chlorogenic (SPI-CA) adducts were characterized. formation covalent indicated by the result SDS-PAGE analysis. UV–vis FTIR analysis that addition CA resulted in changes secondary structure protein. spectroscopy SPI tended to unfold. activity SPI-CA80 (CA concentration is 80 μmol/g protein) highest, which increased 34.77%. Additionally, SPI-CA100 exhibited high capacity, with ABTS DPPH radical scavenging rates 24.83% 14.41%, respectively. results showed correlated CA. Overall, this study demonstrates binding enhances potential application as a functional ingredient food.

Language: Английский

Citations

40
Chlorogenic acids: A pharmacological systematic review on their hepatoprotective effects DOI

Haoyu Xue,

Mengjuan Wei, Lili Ji

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 118, P. 154961 - 154961

Published: July 9, 2023

Language: Английский

Citations

26
Risk Assessment of Chlorogenic and Isochlorogenic Acids in Coffee By-Products DOI Creative Commons
Sascha Behne, Heike Franke, Steffen Schwarz

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(14), P. 5540 - 5540

Published: July 20, 2023

Chlorogenic and isochlorogenic acids are naturally occurring antioxidant dietary polyphenolic compounds found in high concentrations plants, fruits, vegetables, coffee, coffee by-products. The objective of this review was to assess the potential health risks associated with oral consumption by-products containing chlorogenic acids, considering both acute chronic exposure. An electronic literature search conducted, revealing that 5-caffeoylquinic acid (5-CQA) 3,5-dicaffeoylquinic (3,5-DCQA) major Toxicological, pharmacokinetic, clinical data from animal human studies were available for assessment, which indicated no significant evidence toxic or adverse effects following current state knowledge suggests long-term exposure by daily does not appear pose a risk when observed at doses within normal range As result, intake CQAs can be considered reasonably safe.

Language: Английский

Citations

24