Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 317 - 339
Published: Jan. 1, 2023
Language: Английский
FEMS Microbiology Reviews, Journal Year: 2023, Volume and Issue: 47(6)
Published: Oct. 4, 2023
Abstract A number of bacterial species are found in high abundance the faeces healthy breast-fed infants, an occurrence that is understood to be, at least part, due ability these bacteria metabolize human milk oligosaccharides (HMOs). HMOs third most abundant component after lactose and lipids, represent complex sugars which possess unique structural diversity resistant infant gastrointestinal digestion. Thus, reach distal intestine intact, thereby serving as a fermentable substrate for specific intestinal microbes, including Firmicutes, Proteobacteria, especially infant-associated Bifidobacterium spp. help shape gut microbiome. Bacteria utilising equipped with genes associated their degradation carbohydrate-active enzymes known glycoside hydrolase have been identified gut, supports this hypothesis. The resulting degraded can also be used growth substrates other present microbe-microbe interaction ‘cross-feeding’. This review describes current knowledge on HMO metabolism by particular gut-associated bacteria, many currently commercial probiotics, distinct strategies employed individual utilisation.
Language: Английский
Citations
26
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(19), P. 10665 - 10678
Published: May 1, 2024
This review explores the role of microorganisms and metabolites in human breast milk their impact on neonatal health. Breast serves as both a primary source nutrition for newborns contributes to development maturation digestive, immunological, neurological systems. It has potential reduce risks infections, allergies, asthma. As our understanding properties advances, there is growing interest incorporating its benefits into personalized infant strategies, particularly situations which breastfeeding not an option. Future formula products are expected emulate composition advantages milk, aligning with evolving nutrition. The long-term health implications still under investigation.
Language: Английский
Citations
12
Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1287 - 1287
Published: April 25, 2024
Human milk oligosaccharides (HMOs) are complexes that play a crucial role in shaping the early-life gut microbiota. This study intends to explore whether HMO patterns associated with microbiota of infants. We included 96 Chinese breastfeeding mother–infant dyads. Breast and infant faecal samples were collected tested. With 2′-fucosyllactose, difucosyllactose, lacto-N-fucopentaose-I as biomarkers, we divided mothers into secretor non-secretor groups. extracted using principal component analysis. The majority (70.7%) categorised five different identified. After adjustment, infants exhibited lower relative abundance Bifidobacterium bifidum (β = −0.245, 95%CI: −0.465~−0.025). An pattern characterised by high levels 3-fucosyllactose, lacto-N-fucopentaose-III, lacto-N-neodifucohexaose-II was positively breve (p 0.014), while lacto-N-neotetraose, 6′-sialyllactose, sialyllacto-N-tetraose-b negatively 0.027). monofucosyl-lacto-N-hexaose-III monofucosyl-lacto-N-neohexaose dentium 0.025) < 0.001), respectively. suggests from mature breast certain breastfed
Language: Английский
Citations
4
Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 519 - 519
Published: Jan. 30, 2025
The purpose of this study was to investigate the degradation mechanism Bifidobacterium on breast milk oligosaccharides (HMOs) and its application in infant nutrition. composition characteristics HMOs were introduced, by described, including intracellular extracellular digestion species-specific differences. interaction between Bacteroides process degrading effect intestinal microecology analyzed. effects HMO formula powder microbiota infants discussed, simulating composition, regulating flora immune function, infection prevention, brain development. Finally, research results are summarized, future directions proposed provide for field
Language: Английский
Citations
0
Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 973 - 973
Published: March 11, 2025
Breast milk is rich in bioactive components, especially human oligosaccharides (HMOs), which are crucial for establishing gut microbiota. The 2′-FL (2-Fucosyllactose), one of the most abundant breast milk, functions as a selective prebiotic. Objective: To examine effect adding (2-Fucosyllactose) to an infant formula containing prebiotic galacto-oligosaccharides (GOSs) and fructo-oligosaccharides (FOSs) on microbiome healthy formula-fed infants. Methods: This study enrolled infants from three groups: HMO experimental group (n = 29), GOS/FOS control 30), exclusively breastfed (breast [BM]) reference 28). Fecal samples groups first fourth months life were analyzed. V3 V4 regions 16S rRNA gene amplified sequenced Illumina MiSeq. ANOVA, Kruskal–Wallis, richness indices (Chao1, Shannon), UniFrac distances, Adonis tests used perform statistical analyses relative abundance phyla genera, well alpha beta-diversity Results: After intervention, Actinobacteriota emerged predominant phylum both (60.4%) BM (46.6%) groups. Bifidobacterium Escherichia-Shigella identified two bacterial genera Nevertheless, analysis showed that after intervention was similar (p > 0.05). Infants higher [Ruminococcus]_gnavus_group bacteria compared those group. Groups fed with demonstrated alpha-diversity microbiota < 0.05), at time admission intervention. Beta-diversity significantly different among groups, according type feeding. 2′-FL-supplemented exhibited growth comparable throughout period, demonstrating safe tolerated. Conclusions: Adding 4 g/L GOS + FOS resulted stronger bifidogenic without 2′-FL.
Language: Английский
Citations
0
Food Research International, Journal Year: 2025, Volume and Issue: 209, P. 116328 - 116328
Published: April 6, 2025
Language: Английский
Citations
0
Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 128, P. 106800 - 106800
Published: April 8, 2025
Language: Английский
Citations
0
Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2023, Volume and Issue: 23(1)
Published: Dec. 13, 2023
Abstract Breastmilk is seen as the gold standard for infant nutrition it provides nutrients and compounds that stimulate gut barrier, immune, brain development to infant. However, there are many instances where not possible an be fed with breastmilk, especially full 6 months recommended by World Health Organization. In such instances, formula next best approach. formulas do contain human milk oligosaccharides (hMOs), which uniquely present in third most abundant solid component. hMOs have been linked health benefits, of microbiome, immune system, intestinal a healthy brain. This paper reviews effects specific applied on including not‐often‐recognized alkaline phosphatase system prevents inflammation. Additionally, impact immunity current proof neurocognitive function corresponding mechanisms discussed. Recent studies suggest can alter microbiota, modulate barrier function, promote function. The 2′‐fucosyllactose lacto‐ N ‐neotetraose found positive infants deemed safe use formula. their has limited due cost complexity synthesis. Thus, although benefits described, complex combinations other approach prevention disease.
Language: Английский
Citations
9
Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 11(11), P. 6868 - 6877
Published: Aug. 16, 2023
Abstract Intestinal flora is very important for improving the development of immune system in newborns. Maternal diet during pregnancy and lactation one key factors affecting growth offspring. The objective present study was to examine whether supplementation maternal with milk oligosaccharides Bifidobacterium could influence intestinal neonatal mice. In total, 30 pregnant Institute Cancer Research (ICR) mice were randomly divided into six groups: a control group (basal diet) five intervention groups supplemented different doses 2′‐fucosyllactose [2′‐FL] Bb12 ) period. All female monitored physical health gavage. After delivery, number each litter, any deformity, offspring recorded. spleen, blood, fecal samples 10–12 day‐old collected. results demonstrated that probiotics conferred protective effects against lipopolysaccharide (LPS)‐induced immunosuppression by significantly enhancing organ indexes, splenocyte proliferation, immunoglobulin (immunoglobulin G, A, M) production as well macrophage phagocytosis ( p < .05). abundance Lactobacilli Bifidobacteria feces higher than These findings suggest combination 2′‐FL displayed synergistic interactions between two components promote offsprings improve their microbiota through ingestion.
Language: Английский
Citations
8
Foods, Journal Year: 2024, Volume and Issue: 13(13), P. 2157 - 2157
Published: July 8, 2024
The gut has been a focus of chronic disease research. microbiota produces metabolites that act as signaling molecules and substrates, closely influencing host health. Nondigestible oligosaccharides (NDOs), common dietary fiber, play an important role in regulating the structure function microbiota. Their mechanism action is mainly attributed to providing carbon source specific probiotics, producing related metabolites, microbial community. However, due selective utilization oligosaccharides, some factors, such type have different impacts on composition populations production colon ecosystem. This review systematically describes key factors by microorganisms elaborates how affect host’s immune system, inflammation levels, energy metabolism diversity metabolic function, which turn affects onset progress diseases, especially diabetes, obesity, depression, intestinal inflammatory constipation. In this review, we re-examine interaction mechanisms between its associated explore new strategies for promoting human health combating diseases through interventions.
Language: Английский
Citations
2