The effect of goat-milk-based formulas on infant health DOI Creative Commons
И. Н. Захарова, Narine G. Sugian, Yana V. Orobinskaya

et al.

Meditsinskiy sovet = Medical Council, Journal Year: 2024, Volume and Issue: 11, P. 93 - 99

Published: Aug. 6, 2024

Breast milk is the “gold standard” for feeding infants first years of life and affects children health both at an early age in subsequent periods their life. However, there are times when women unable to breastfeed following reasons: a woman cannot make or has problems, lose interest breastfeeding, should be back work, etc. This brings up legitimate question: how choose among large number infant formulas healthy one that will fit safe child use, taking into account gestational age, as well individual “risk facts” such high low body mass height parameters, features childbirth (“vaginal”, operative delivery), Most often, choice falls on cow-milk-based formula. After all, not forget about alternative options goat-milk-based formulas. Historical evidence shows patients with rickets were fed goat it was believed affect brain functions. Interest beneficial effects goat’s been steadily increasing this day, given biological active substances present also women’s larger quantities. The β -casein fraction its main component, which makes similar breast structure possible. In addition proteins, fats components contribute excellent digestibility milk. Their distinctive feature smaller size compared from other animals. article explores all benefits effect aspects health.

Language: Английский

Bioactive Components of Human Milk and Their Impact on Child’s Health and Development, Literature Review DOI Open Access
Hubert Szyller, Katarzyna Antosz, Joanna Batko

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1487 - 1487

Published: May 14, 2024

The composition of human breast milk is an ideal combination substances necessary for the healthy development infant’s body while protecting from pathogens and balanced microbiota. Its dynamic changes with age child, meeting their current needs. study provides a thorough overview components, such as immunological growth factors, hormones, carbohydrates, lipids, minerals, vitamins. Authors focus on capturing most important aspects effects these newborn’s body, also looking specific connections describing given systems. Supplementation use ingredients are discussed. purpose this paper to present state knowledge about bioactive components impact growth, development, health young child.

Language: Английский

Citations

11
Interactions of human milk oligosaccharides with the immune system DOI Creative Commons

A. Slater,

Rita M. Hickey, Gavin P. Davey

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 14, 2025

Human milk oligosaccharides (HMOs) are abundant, diverse and complex sugars present in human breast milk. HMOs well-characterized barriers to microbial infection by modulating the microbiome they also thought be nutritionally beneficial infant. The structural variety of over 200 HMOs, including neutral, fucosylated sialylated forms, allows them interact with immune system various ways. Clinically, impact allergic diseases, reducing autoimmune inflammatory responses, offer support preterm infant health. This review examines HMO composition associated immunomodulatory effects, interactions cell receptors gut-associated responses. These properties highlight potential for use early stage development as novel immunotherapeutics. research is rapidly evolving promises innovative treatments immune-related conditions improved health outcomes.

Language: Английский

Citations

1
EASyMap-Guided Stepwise One-Pot Multienzyme (StOPMe) Synthesis and Multiplex Assays Identify Functional Tetraose-Core-Human Milk Oligosaccharides DOI Creative Commons
Yuanyuan Bai, Anand K. Agrahari, Libo Zhang

et al.

JACS Au, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Carbohydrates are biologically and medicinally important molecules that attracting growing attention to their synthesis applications. Unlike the biosynthetic processes for nucleic acids proteins, carbohydrate biosynthesis is not template-driven, more challenging, often leads product variations. In lieu of templates biosynthesis, we describe herein a new concept designing enzyme assembly synthetic maps (EASyMaps) as blueprints guide glycosyltransferase-dependent stepwise one-pot multienzyme (StOPMe) systematically access structurally diverse carbohydrates in target-oriented manner. The strategy demonstrated construction comprehensive library tetraose-core-containing human milk oligosaccharides (HMOs) presenting functional glycan epitopes shared by complex HMOs. tetraose-core-HMOs attractive candidates large-scale production development HMO-based nutraceuticals. To achieve preparative-scale targets containing Neu5Acα2–6GlcNAc component, α2–6-sialyltransferase hST6GALNAC5 successfully expressed E. coli. Neoglycoproteins with controlled valencies prepared immobilized on fluorescent magnetic beads. Multiplex bead assays reveal ligands glycan-binding proteins from plants, influenza viruses, human, bacteria, identifying promising HMO EASyMaps StOPMe systematic manner broadly applicable beyond efficient process suitable can be potentially adapted automation.

Language: Английский

Citations

1
Early life gut microbiome and its impact on childhood health and chronic conditions DOI Creative Commons

Harold Núñez,

Pamela A. Nieto,

Ruben A. T. Mars

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 7, 2025

The development of the gut microbiome is crucial to human health, particularly during first three years life. Given its role in immune development, disturbances establishment process may have long term consequences. This review summarizes evidence for these claims, highlighting compositional changes this critical period life as well factors that affect development. Based on and animal data, we conclude early-life a determinant long-term impacting physiological, metabolic, processes. field faces challenges. Some challenges are technical, such lack standardized stool collection protocols, inconsistent DNA extraction methods, outdated sequencing technologies. Other methodological: small sample sizes, longitudinal studies, poor control confounding variables. To address limitations, advocate more robust research methodologies better understand microbiome's health disease. Improved methods will lead reliable studies deeper understanding impact outcomes.

Language: Английский

Citations

1
Production, Composition and Nutritional Properties of Organic Milk: A Critical Review DOI Creative Commons
Kevin Linehan, Dhrati Patangia, R. Paul Ross

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(4), P. 550 - 550

Published: Feb. 11, 2024

Milk is one of the most valuable products in food industry with milk production throughout world being carried out using conventional management, which includes intensive and traditional systems. The use fertilizers, antibiotics, pesticides concerns regarding animal health environment have given increasing importance to organic dairy last two decades. This review aims compare production, nutritional, compositional properties produced by management We also shed light on benefits worldwide scenario system. Most reports suggest has beneficial effects very few, if any, adverse reported. Organic reported confer additional due its lower omega-6-omega-3 ratio, difference feeding practices, cows predominantly pasture fed. Despite testified animal, host, environmental benefits, difficult several regions cost-intensive process geographical conditions. Finally, we offer perspectives for a better future highlight knowledge gaps

Language: Английский

Citations

7
Bifidobacterium fermentation with infant formulas is associated with benefits for gut and brain barrier function DOI
Emily G. Knox,

Paula Sánchez-Díaz,

Colin Buttimer

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 125, P. 106661 - 106661

Published: Jan. 16, 2025

Language: Английский

Citations

0
Bioactive compounds in human milk DOI
Anthony E. Castro, Maria Sanchez-Holgado, Miguel Sáenz de Pipaón

et al.

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Purpose of review: Human milk is the optimal food choice for infants. Reviewing latest advances in research about human compounds and their effect on health helps understand benefits breastfeeding improves knowledge key bioactive nutrients that can be used to improve feeding during infancy, with short long-time effects health. Recent findings: In last years, it has been described how such as oligosaccharides, hormones, lipids, cellular components microbes play an important role infants’ health, reducing risk infectious, metabolic autoimmune diseases. The mechanisms transmission from mother infant these are not always well described, but there several lines biological beneficial effects. Summary: These findings may help maternal interventions, modifiable factors able modulate composition. They development formulas enhance nutritional plans. Also, identification isolation describe new ways supplementation.

Language: Английский

Citations

0
Goat milk oligosaccharides: regulating infant immunity by intervention in the gut microbiota DOI
Sibo Liu, Xiaoling Zeng, Jing Li

et al.

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The health status of the growing infant is closely related to development gut microbiota during infancy, which also a major stimulator immune system.

Language: Английский

Citations

0
High-Throughput Screening and Directed Evolution of β-1,3-N-Acetylglucosaminyltransferase for Enhanced LNnT Production in Engineered Saccharomyces cerevisiae DOI
Han Liu,

Quan-Ming Zeng,

Chenlu Zhu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Lacto-N-triose II (LNTII), lacto-N-tetraose (LNT), and lacto-N-neotetraose (LNnT) are key neutral human milk oligosaccharides (HMOs) with significant physiological functions. In cell factory-based synthesis, glycosyltransferases rate-limiting enzymes, enhancing the activity of which is, therefore, crucial for efficient synthesis HMOs. To address this issue, we developed a high-throughput screening method based on UDP-glucose regeneration-coupled colorimetric reaction. As case study, applied directed evolution β-1,3-N-acetylglucosamine transferase in Saccharomyces cerevisiae (S. cerevisiae), resulting mutant strain that doubled LNnT production. Additionally, by metabolic flux heterologous pathway, further elevated total titer to 1.29 g/L, setting new record production S. cerevisiae. Our study demonstrates effectiveness disaccharide assay provides strategy improving biosynthetic efficiency HMOs release UDP during process.

Language: Английский

Citations

0
Technical review by the ESPGHAN special interest group on gut microbiota and modifications on the health outcomes of infant formula supplemented with manufactured human milk oligosaccharides DOI Open Access
Iva Hojsak, Ener Çağrı Dinleyici, Chris H.P. van den Akker

et al.

Journal of Pediatric Gastroenterology and Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract This technical review, one of five developed by the European Society for Pediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) special interest group (SIG) on gut microbiota modifications (GMM), supports creation a position paper use biotic‐supplemented formulas, including those containing human milk oligosaccharides (HMOs) produced through chemical synthesis or microbial biotechnology. Though these are identical to HMOs found in milk, they do not originate from it. Therefore, we used human‐identical (HiMOs). review focuses clinical outcomes related supplementation infant formulas with HiMOs. The ESPGHAN SIG‐GMM conducted systematic evaluate HiMO‐supplemented healthy infants (0–12 months) published before 2024. Six RCTs two mechanistic substudies met inclusion criteria investigated different combinations HiMOs added formula. studied so far show no difference compared control formula such as: anthropometric data, regurgitation‐related symptoms, crying, fussiness, colic. A specific combination HMO‐analogues (2′fucosyllactose [FL], 3‐FL, lacto‐N‐tetraose [LNT], 3′‐sialyllactose [SL], 6′‐SL) suggest softer stool consistency more frequent defecation presumable infants, but studies also highest amount HiMOs; however, relevance this finding remains uncertain. Regarding infection prevention, clear conclusion can be drawn. There was tolerability safety concerns were raised HiMO far. report serves as background formulating recommendations HiMOs‐supplemented

Language: Английский

Citations

0