Bifidobacterium Longum (BLM) Alleviate Intestinal Inflammation and Damage Caused by Methotrexate (MTX) in Psoriasis DOI
Manyun Mao, Li Rao,

Chenyang Cang

et al.

Published: Jan. 1, 2023

Background: Methotrexate (MTX) is a traditional first-line drug for moderate to severe psoriasis, but its unpredictable efficacy and toxic side effects limit clinical use. In this study, we aim investigate the of bifidobacterium longum (BLM) in combination with MTX protective effect on intestine.Results: The results showed that co-treatment BLM can enhance alleviate psoriasis skin lesions mice. Co-treatment significantly weight loss intestinal tissue inflammation induced by treatment, reduce mesenteric permeability plasma calprotectin levels, promote differentiation Treg cells immune system. Interestingly, non-targeted metabolomic sequencing found increase concentration propionate mice gut. Propionate intervention effectively MTX-induced toxicity, it has no significant synergistic treatment MTX.Conclusions: provide beneficial gut tissues system IMQ-induced psoriasis-like as well further improve health mice.Funding: This work supported Grants from National Natural Science Foundation China (81974479, 81773329, 82073447), Key Research Grant (2018YFC0117004).Declaration Interest: authors have conflict interest declare.Ethical Approval: All animal procedures were conducted accordance guidelines European Community Directive 2010/63/EU approved Ethics Committee Central South University (CSU-2022-0376).

Language: Английский

Role of Bifidobacterium in Modulating the Intestinal Epithelial Tight Junction Barrier: Current Knowledge and Perspectives DOI Creative Commons
Raz Abdulqadir,

Jessica Engers,

Rana Al–Sadi

et al.

Current Developments in Nutrition, Journal Year: 2023, Volume and Issue: 7(12), P. 102026 - 102026

Published: Oct. 30, 2023

The intestinal tight junction (TJ) barrier is a crucial defense mechanism that prevents the passage of content into wall, tissue, and systemic circulation. A compromised TJ has been identified as significant factor in inflammatory bowel disease (IBD), necrotizing enterocolitis, other gut-related conditions. Recent studies have revealed importance probiotic bacterial strains Bifidobacterium protecting against inflammation IBD pathogenesis via regulation function. Numerous species found to regulate proteins signaling pathways responsible for maintaining integrity permeability. In this review, we provide summary recent highlight regulatory role strain effect on barrier. We also discuss intracellular mechanisms involved modulation potential therapeutic efficacy targeting function inflammation.

Language: Английский

Citations

31
Integrative metabolomics and gut microbiota analyses reveal the protective effects of DHA-enriched phosphatidylserine on bisphenol A-induced intestinal damage DOI Creative Commons

Qiaoling Zhao,

Fei Yang,

Qiuyan Pu

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 117, P. 106229 - 106229

Published: May 7, 2024

The protective effects of docosahexaenoic acid-enriched phosphatidylserine (DHA-PS, 50 or 100 mg/kg) on bisphenol A (BPA)-induced intestinal damage were assessed. biochemical indices, pathological examination, non-targeted metabolomics integrated with gut microbiota analysis, and immunofluorescence analysis used to investigate the DHA-PS its underlying regulatory mechanism. treatment improved pathology tract increased expression levels Claudin-1, Occludin, ZO-1. In addition, also notably decreased interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, antioxidant enzymes activities. Moreover, relative abundances Akkermansia, Alistipes, Butyricicoccus, Coriobacteriaceae_UCG-002, Enterorhabdus, Lachnospiraceae_UCG-006. alleviated BPA-induced by regulating kynurenine pathway tryptophan, lipid, arachidonic acid metabolisms. Overall, this study suggested that could alleviate enhancing barrier integrity, improving microbial composition metabolites, inhibiting TLR4/NF-κB pathways.

Language: Английский

Citations

13
Probiotics: Shaping the gut immunological responses DOI Creative Commons
Eirini Filidou, Leonidas Kandilogiannakis, Anne Shrewsbury

et al.

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(15), P. 2096 - 2108

Published: April 19, 2024

Probiotics are live microorganisms exerting beneficial effects on the host's health when administered in adequate amounts. Among most popular and adequately studied probiotics bacteria from families

Language: Английский

Citations

11
The Sanbi Decoction alleviates intervertebral disc degeneration in rats through intestinal flora and serum metabolic homeostasis modulation DOI
Nan Wang, Shuang Chen,

Yimin Xie

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 127, P. 155480 - 155480

Published: Feb. 24, 2024

Language: Английский

Citations

8
Research Progress on the Correlation Between Hypertension and Gut Microbiota DOI Creative Commons
Xiao-mei Cui, Ting Zhang, Tao Xie

et al.

Journal of Multidisciplinary Healthcare, Journal Year: 2024, Volume and Issue: Volume 17, P. 2371 - 2387

Published: May 1, 2024

Among cardiovascular diseases, hypertension is the most important risk factor for morbidity and mortality worldwide, its pathogenesis complex, involving genetic, dietary environmental factors. The characteristics of gut microbiota can vary in response to increased blood pressure (BP) influence development progression hypertension. This paper describes five aspects relationship between microbiota, namely, different types metabolites sympathetic activation, gut-brain interactions, effects exercise patterns treatment through probiotics, faecal transplantation (FMT) herbal remedies, providing new clues future prevention Diet, traditional Chinese medicine may contribute long-term improvements hypertension, although probiotics FMT still need be validated large populations.

Language: Английский

Citations

7
Bifidobacterium and the intestinal mucus layer DOI Open Access
Alyssa Gutierrez,

Brenton Pucket,

Melinda A. Engevik

et al.

Microbiome Research Reports, Journal Year: 2023, Volume and Issue: 2(4)

Published: Sept. 27, 2023

Bifidobacterium species are integral members of the human gut microbiota and these microbes have significant interactions with intestinal mucus layer. This review delves into -mucus dynamics, shedding light on multifaceted nature this relationship. We cover conserved features interactions, such as adhesion positive regulation goblet cell production, well strain-specific attributes degradation. For each interface, we explore molecular mechanisms underlying their potential implications for health. Notably, emphasize ability to positively influence layer, its a mucin-builder therapeutic agent diseases associated disrupted barriers. By elucidating complex interplay between mucus, aim contribute deeper understanding microbiota-host interface pave way novel strategies.

Language: Английский

Citations

15
Valsartan attenuates LPS-induced ALI by modulating NF-κB and MAPK pathways DOI Creative Commons

Mi Zhou,

Ling Meng,

Qinke He

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 15, 2024

Background: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common disease characterized by persistent hypoxemia and an uncontrolled inflammatory response. Valsartan, angiotensin II type 1 receptor antagonist, clinically used to treat hypertension has anti-inflammatory antioxidant effects on gefitinib-induced pneumonia in rats. However, the potential therapeutic of valsartan lipopolysaccharide (LPS)-induced ALI remain unclear. This study investigated protective role LPS-induced its underlying mechanisms. Methods: LPS-treated BEAS-2B cells mouse model were established. treated with LPS (10 μg/mL) for 24h, or without (20, 40, 80 µM). For models, (5 mg/kg) was administered through intratracheal injection mice 30 injected intraperitoneally twice 2 h before 12 after injection. Pulmonary functional parameters examined EMKA pulmonary system. Hematoxylin eosin staining, flow cytometry, CCK-8 assay, qRT-PCR, ELISA, immunofluorescence, Western blotting, related commercial kits assess pathological damage lungs, neutrophil recruitment tissue bronchoalveolar lavage fluid (BALF), cell viability, inflammation, oxidative activity, mucus production, respectively. Potential mechanisms further explored using network pharmacology blotting. Results: Valsartan rescued LPS-reduced viability cells, improved function, ameliorated ALI, BALF mice, attenuated stress increasing level SOD decreasing that MDA GSSG, inhibited MUC5AC overproduction, decreased increase expression pro-inflammatory cytokines/chemokines including TNF-α, IL-6, IL-1β, CXCL-1 CXCL-2, restored IL-10. Mechanistic studies showed inhibits phosphorylation nuclear factor-kappa B (NF-κΒ) mitogen-activated protein kinases (MAPKs) P38, extracellular signal-regulated kinase (ERK), c-Jun N-terminal (JNK) both ALI. Conclusion: protects against attenuating stress, reducing response may involve MAPK NF-κΒ pathways.

Language: Английский

Citations

4
The gut-lung axis in critical illness: microbiome composition as a predictor of mortality at day 28 in mechanically ventilated patients DOI Creative Commons

Piaopiao Zhou,

Zhiqiang Zou, Wenwei Wu

et al.

BMC Microbiology, Journal Year: 2023, Volume and Issue: 23(1)

Published: Dec. 18, 2023

Microbial communities are of critical importance in the human host. The lung and gut microbial represent most essential microbiota within body, collectively referred to as gut-lung axis. However, differentiation between these their influence on clinical outcomes critically ill patients remains uncertain.

Language: Английский

Citations

11
Dietary supplement of Acanthopanax senticosus decoction formula improves immune response via intestine flora of rabbits DOI Creative Commons

Jing Nie,

Qin Liu,

Shihui Huang

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: March 4, 2025

Young rabbits are sensitive to surrounding changes and conditioned pathogens in intestine which might result slow inflammation diarrhea after microbial invasion. Traditional medicine herbs could provide efficacious treatment on infection inflammation. The present research designed an Acanthopanax senticosus (ACS) formula consisted of five types Chinese including (Rupr & Maxim) Harms (Ciwujia Chinese), Astragalus membranceus (Fisch) Bge (Huangqi Indigo naturalis (Qingdai Houttuynia cordata Thunb (Yuxingcao Glycyrrhizae radix et Rhizoma (Gancao Chinese). effects ACS decoction supplement were investigated via determination cytokines growth performances young rabbits, the flora intestinal digesta from six fragments further explored using 16S rRNA gene sequencing technology. Compared control group, supplied with different doses possessed lower death rates, together IL-10 concentration, while declined IL-1β IL-12 levels inflammatory factor expressions tissues. Additionally, addition changed diversity each segments intestine. Functional prediction abundances genera enriched seven KEGG immunity pathways. Moreover, strong correlations determined between abundance bacteria interleukins contents, predictive immune signaling abundances, respectively. Especially, exhibited anti-inflammation decreasing Bacteroides , Clostridia_vadinBB60_group NK4A214_group dgA_11_gut_group rabbits. In conclusion, dietary exerted diarrhea-reducing effects, improved homeostasis by modulating

Language: Английский

Citations

0
Probiotic Supplementation Contributes to Glycemic Control in Adults with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis DOI
Dengrong Ma, Pingping Zhao, Jie Gao

et al.

Nutrition Research, Journal Year: 2025, Volume and Issue: 136, P. 133 - 152

Published: March 7, 2025

Language: Английский

Citations

0