Targeted modulation of intestinal barrier and mucosal immune-related microbiota attenuates IgA nephropathy progression

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 28, 2025

IgA nephropathy (IgAN) is related to the balance of gut microbiota. However, it unclear whether changes in microbiota can cause IgAN or attenuate its progression. This study employed and human microbiota-associated (HMA)-IgAN models investigate impact on alteration mechanisms by which might trigger IgAN. Furthermore, this examined effects chitooligosaccharides (COS) COS formulation (COSF) with microbiota-targeting function enhancing intestinal barrier renal functions. These results revealed that led a reduction α-diversity structural alterations microbiota, characterized an increase Shigella sonnei, Streptococcus danieliae, Desulfovibrio fairfieldensis, decrease Bifidobacterium pseudolongum Clostridium leptum. There was also imbalance B-cell immunity level tight junction proteins (ZO-1 Occludin). Intestinal mucosal immune-related (Clostridium leptum, unclassified Lachnospiraceae NK4Al36 group, Clostridia vadinBB60 Oscillospiraceae, Roseburia) were enriched through targeted modulation COS/COSF, ZO-1 expression reducing APRIL/BAFF overexpression, thereby damage In conclusion, clarified kidney-gut crosstalk between IgAN, providing scientific evidence for developing microbiota-targeted food interventions improve outcomes.

Language: Английский

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Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer’s Disease

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 558 - 558

Published: Jan. 31, 2025

Alzheimer’s disease (AD) is the most common form of dementia and characterized by memory impairment that significantly interferes with daily life. Therapeutic options for AD substantively modify progression remain a critical unmet need. In this regard, gut microbiota crucial in maintaining human health regulating metabolism immune responses, increasing evidence suggests probiotics, particularly beneficial bacteria, can enhance cognitive functions. Recent studies have highlighted positive effects Bifidobacterium breve MCC1274 (B. MCC1274) on individuals mild (MCI) schizophrenia. Additionally, oral supplementation B. has been shown to effectively prevent decline AppNL–G–F mice. relation pathology, found reduce amyloid-β (Aβ) accumulation tau phosphorylation both wild-type (WT) It also decreases microglial activation increases levels synaptic proteins. review, we examine AD, exploring potential mechanisms action how probiotic strain may aid preventing or treating disease. Furthermore, discuss broader implications improving overall host provide insights into future research directions promising therapy.

Language: Английский

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MIIST305 mitigates gastrointestinal acute radiation syndrome injury and ameliorates radiation-induced gut microbiome dysbiosis

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 10, 2025

High-dose radiation exposure results in gastrointestinal (GI) acute syndrome identified by the destruction of mucosal layer, intestinal growth barrier dysfunction, and aberrant inflammatory responses. Further, causes gut microbiome dysbiosis characterized diminished microbial diversity, mostly commensal bacteria, spread bacterial pathogens that trigger recruitment immune cells production pro-inflammatory factors lead to further GI tissue damage. Currently, there are no U.S. Food Drug Administration (FDA) approved countermeasures can treat radiation-induced injuries. To meet this critical need, Synedgen Inc. has developed a glycopolymer radiomitigator (MIIST305) is specifically targeted tract, which acts intercalating into mucus layer glycocalyx epithelial could potentially ameliorate deleterious effects radiation. Male C57BL/6J adult mice were exposed 13 Gy partial body X-irradiation with 5% bone marrow shielding MIIST305 was administered on days 1, 3, 5 post-irradiation. Approximately 85% animals survived irradiation apparently healthy until end 30-day study period. In contrast, control, Vehicle-treated past day 10 at dose. We show improved function suppressed systemic responses mediated cytokines. Taxonomic profiling community structure fecal colonic mucosa microbiota demonstrated treatment increased diversity restored abundance beneficial including Lactobacillus Bifidobacterium genera while suppressing pathogenic bacteria Enterococcus Staphylococcus compared animals. summary, novel GI-targeted therapeutic greatly enhances survival lethal protects tract from injury restoring balanced reducing Further development drug as an FDA-approved medical countermeasure importance.

Language: Английский

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Microglia and Gut Microbiota: A Double-Edged Sword in Alzheimer's Disease

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102515 - 102515

Published: Sept. 1, 2024

Language: Английский

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Understanding How Pre- and Probiotics Affect the Gut Microbiome and Metabolic Health

AJP Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 327(1), P. E89 - E102

Published: May 29, 2024

The gut microbiome, a complex assembly of microorganisms, significantly impacts human health by influencing nutrient absorption, the immune system, and disease response. These microorganisms form dynamic ecosystem that is critical to maintaining overall well-being. Prebiotics probiotics are pivotal in regulating microbiota composition. nourish beneficial bacteria promote their growth, whereas help maintain balance within microbiome. This intricate extends several aspects health, including integrity barrier, responses, producing metabolites crucial for metabolic health. Dysbiosis, or an imbalance microbiota, has been linked disorders such as type 2 diabetes, obesity, cardiovascular disease. Impaired barrier function, endotoxemia, low-grade inflammation associated with toll-like receptors proinflammatory pathways. Short-chain fatty acids derived from microbial fermentation modulate anti-inflammatory system positively influence probiotics, especially Lactobacillus Bifidobacterium strains, may improve outcomes, glycemic control diabetes. It important consider strain-specific effects study variability when interpreting these findings, highlighting need further research optimize therapeutic potential. aim this report therefore review role prebiotics on microbiome role, integrating broad understanding physiological mechanisms clinical perspective.

Language: Английский

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Evaluation of Safety and Beneficial Health Effects of the Human-Milk Strain Bifidobacterium breve DSM32583: An Infant Pilot Trial

Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1134 - 1134

Published: April 11, 2024

Human milk promotes the growth of bifidobacteria in infant gut. Adding bifidobacterial species to formula may contribute increasing their presence gut formula-fed infants. Therefore, safety and anti-infectious effects Bifidobacterium breve DSM32583, a breast isolate, were assessed pilot trial involving 3-month-old The infants randomly assigned either probiotic (PG) or control (CG) groups. All consumed same formula, although it was supplemented with strain (1 × 107 cfu/g formula) PG. Overall, 160 (80 per group) finished intervention. Infants CG gained more weight compared PG (p < 0.05), but weights for age Z-scores at 6 months within normal distribution this group. rates infections affecting gastrointestinal respiratory tracts antibiotic therapy significantly lower population level short-chain fatty acids higher 0.05) fecal samples No adverse events related consumption observed. In conclusion, administration an B. DSM32583 safe exerted potential beneficial on health.

Language: Английский

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Dissecting casual effects of diet on the risk of inflammatory bowel disease and the potential mediation by gut microbiota: a Mendelian randomization study

Food, Nutrition and Health., Journal Year: 2025, Volume and Issue: 2(1)

Published: Jan. 3, 2025

Abstract Background Diet plays a fundamental role in maintaining intestinal health. Here, we investigated whether there is the causal association of diet with inflammatory bowel disease (IBD), and potential effect gut microbiota on these relationships, by using two-sample Mendelian randomization (MR) analyses. Materials methods Genetic instruments for 29 dietary intake variables 139 food-liking traits were obtained from UK-Biobank. The GWAS statistics IBD its two subtypes, ulcerative colitis (UC) Crohn's (CD), IEU database. microbiome was MiBioGen alliance. Associations assessed inverse-variance weighted method, MR-Egger, median, simple mode mode. Gut mediated associations IBD. Results We identified between 21 factors (including 3 18 traits) IBD, UC and/or CD. These affected 22 bacteria genera, among them, 9 causally associated risk. Notably, Ruminococcus_torques_group , symbiotic bacterium possessing anti-inflammatory properties, significantly relationship various (e.g., liking acquired taste, strong flavor, blue cheese beans) risks. Ruminococcaceae UCG003 showed significant mediating efficacy relation sharp flavor Conclusion Our study reveals impacts risk provides novel insights modulating as therapeutic targets prevention.

Language: Английский

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Dietary Interventions, Supplements, and Plant-Derived Compounds for Adjunct Vitiligo Management: A Review of the Literature

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 357 - 357

Published: Jan. 20, 2025

Vitiligo is a chronic autoimmune pigmentation disorder shaped by complex interplay of genetic predispositions and environmental triggers. While conventional therapies—phototherapy, corticosteroids, immunosuppressants—can be effective, their benefits are often partial temporary, with recurrence common once treatment stops. As such, there increasing interest in exploring complementary approaches that may offer more sustainable impact. Emerging evidence suggests macronutrient micronutrient-level changes could beneficial for managing progression and, some cases, facilitating repigmentation. Antioxidant-rich foods, such as apples, green tea, Indian gooseberry, onions, peppers, help mitigate oxidative stress, while inflammatory gluten high-phenol nuts berries, exacerbate the condition. Certain supplements, including high-dose vitamin D, C, E, selenium, enhance phototherapy outcomes. Omega-3 other unsaturated fatty acids, addition to prebiotics probiotics, under active investigation roles gut health immune regulation. Notably, plant-derived compounds, i.e., Ginkgo biloba, have demonstrated promise promoting repigmentation disease progression. However, it must emphasized these nutritional interventions remain exploratory, research needed establish efficacy, safety, optimal usage before they can recommended part standard regimen.

Language: Английский

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Probiotic Bifidobacterium bifidum strains desialylate MUC13 and increase intestinal epithelial barrier function

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 13, 2025

Abstract Probiotic bacteria including Bifidobacterial species have the capacity to improve intestinal health, but underlying molecular mechanisms are often not understood. Bifidobacteria considered keystone a relatively low abundance in adult tract. Bifidobacterium colonization depends on degradation of host-derived carbohydrates, human milk oligosaccharides and mucin-associated oligosaccharides. Specific strains can enhance barrier integrity symptoms gastrointestinal disorders. We previously reported that transmembrane mucin MUC13 localizes apical lateral membrane regulates epithelial tight junction strength. Here, we screened probiotic bacterial for their modulate function. Of these bacteria, bifidum strain uniquely degraded O- glycosylated extracellular domain. Further characterization two B. (W23 W28) type 20456 demonstrated W23 W28 adhered strongly surface, had high sialidase activity, penetrated mucus layer, enhanced integrity. These results underscore strain-specific properties specific most likely contribute effects

Language: Английский

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Effects of refrigeration-induced protein oxidation of rice and wheat steamed bread on the human gut microbiota in an in vitro fermentation model

LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117657 - 117657

Published: March 1, 2025

Language: Английский

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