Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Nov. 18, 2024
Language: Английский
Future Science OA, Journal Year: 2025, Volume and Issue: 11(1)
Published: Feb. 7, 2025
Aim This study aims to explore a sustainable and scalable approach using tomato fruit-derived sEVs (TsEVs) deliver calcitriol for enhanced anticancer effects, addressing challenges of low yield high costs associated with mammalian cell-derived sEVs.
Language: Английский
Citations
2
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: March 10, 2025
Metabolic-Associated Fatty Liver Disease (MAFLD) is the most common chronic liver disease worldwide, associated with systemic metabolic dysregulation. It can progress from simple hepatic steatosis (MAFL) to more severe conditions like Steatohepatitis (MASH), fibrosis, cirrhosis, and Hepatocellular Carcinoma (HCC). There a critical lack of reliable non-invasive diagnostic methods effective pharmaceutical treatments for MAFLD/MASH, emphasizing need further research. Extracellular vesicles (EVs) are nanoscale structures that play important roles in cell signaling by delivering bioactive molecules. However, there significant gap literature regarding EVs hosts, plants, microbiota MAFLD. This review explores potential various sources—host, microbiota—as biomarkers, therapeutic agents, drug carriers, treatment targets Firstly, host-derived extracellular MAFLD, focus on cell-type specific their components—proteins, miRNAs, lipids—for diagnosis monitoring were discussed. Moreover, it highlighted mesenchymal stem (MSC)-derived reducing lipid accumulation injury, immune cell-derived mitigating inflammation fibrosis. The also discussed use as carriers due ability deliver molecules impact mechanisms. Additionally, summarized research plant-derived EVs, which help reduce accumulation, inflammation, enhance gut barrier function Also, explored microbial-derived novel targets, particularly relation insulin resistance, dysfunction Overall, exploring diverse host, plant, sources this offers valuable insights into biomarkers strategies, could pave way options increasingly prevalent disease. Notably, challenges translating clinical practice thoroughly discussed, aiming provide possible directions strategies future
Language: Английский
Citations
1
Foods, Journal Year: 2024, Volume and Issue: 13(10), P. 1492 - 1492
Published: May 11, 2024
Agri-food wastes generated by industrial food processing are valorized through the extraction of biomolecules to obtain value-added products useful for various applications. In present review, we describe valuable by-products and bioactive molecules that can be obtained from agricultural propose extracellular vesicles (EVs) as innovative nutraceutical therapeutic compounds could derived agriculture residues. To support this idea, described general features roles EVs focused on plant-derived (PDEVs) considered natural carriers involved in intercellular communication between diverse kingdoms life. Consistently, PDEVs exert beneficial effects (anti-inflammatory, anti-tumor, immune-modulatory) mammalian cells. Although research field is currently its infancy, near future, isolation their use tools represent a new way valorize waste agri-food industry an ecofriendly way.
Language: Английский
Citations
5
Processes, Journal Year: 2024, Volume and Issue: 12(12), P. 2938 - 2938
Published: Dec. 23, 2024
Plant-derived extracellular vesicles (PDEVs) are lipid bilayer nanoparticles, naturally produced by plant cells, with sizes ranging from 50 to 500 nm. Recent studies have highlighted their great potential in the biotechnological and medical fields, due natural origin, high biocompatibility intrinsic therapeutic properties. PDEVs contain a complex biological cargo of proteins, lipids, nucleic acids secondary metabolites, including antioxidants anti-inflammatory molecules, making them ideal for biomedical applications such as drug delivery. These play key role intercellular communication gene regulation, proving be particularly promising personalized medicine. ability improve stability bioavailability, optimizing targeted release minimizing side effects. Despite some challenges, compositional variability need standardized protocols, at gunsight innovative research aimed improving loading capacity specificity. This review aims provide comprehensive overview PDEVs, exploring structure, isolation methods, functional characteristics, applications, highlighting advantages over synthetic nanoparticles animal-derived vesicles, leading an sustainable solution development new approaches.
Language: Английский
Citations
4
Obesity Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100597 - 100597
Published: Feb. 1, 2025
Language: Английский
Citations
0
Biotechnology and Bioprocess Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
Language: Английский
Citations
0
Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144303 - 144303
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Cluster Science, Journal Year: 2025, Volume and Issue: 36(3)
Published: May 10, 2025
Language: Английский
Citations
0
Toxics, Journal Year: 2024, Volume and Issue: 12(9), P. 653 - 653
Published: Sept. 5, 2024
Polycyclic aromatic hydrocarbons (PAHs) are persistent organic pollutants that pose significant environmental and health risks. These compounds originate from both natural phenomena, such as volcanic activity wildfires, anthropogenic sources, including vehicular emissions, industrial processes, fossil fuel combustion. Their classification carcinogenic, mutagenic, teratogenic substances link them to various cancers disorders. PAHs categorized into low-molecular-weight (LMW) high-molecular-weight (HMW) groups, with HMW exhibiting greater resistance degradation a tendency accumulate in sediments biological tissues. Soil serves primary reservoir for PAHs, particularly areas of high creating substantial risks through ingestion, dermal contact, inhalation. Coastal aquatic ecosystems especially vulnerable due concentrated human activities, PAH persistence disrupting microbial communities, inhibiting plant growth, altering ecosystem functions, potentially leading biodiversity loss. In plants, contamination manifests form abiotic stress, inducing oxidative cellular damage, growth inhibition. Plants respond by activating antioxidant defenses stress-related pathways. A notable aspect defense mechanisms involves plant-derived extracellular vesicles (PDEVs), which membrane-bound nanoparticles released cells. PDEVs play crucial role enhancing facilitating intercellular communication coordinating responses. The interaction between PDEVs, while not fully elucidated, suggests complex interplay mechanisms. may contribute detoxification pollutant sequestration or delivering enzymes capable degradation. Studying provides valuable insights stress resilience offers potential new strategies mitigating PAH-induced plants ecosystems.
Language: Английский
Citations
2
Food & Function, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Plant-derived extracellular vesicles (PDEVs) are nanoscale released from plant cells into the space. While similar in structure and function to mammalian-derived EVs, PDEVs unique due their origin specific metabolites they carry. have gained significant attention recent years, with numerous reports isolating different various plants, each exhibiting diverse biological functions. However, field is still its early stages, many issues need further exploration. To better develop utilize PDEVs, it essential a comprehensive understanding of characteristics. This review provides an overview advances PDEV research. It focuses on methods techniques for purifying comparing respective advantages, limitations, application scenarios. Furthermore, we discuss latest discoveries regarding composition including lipids, proteins, nucleic acids, metabolites. Additionally, detail advanced studies multiple functions PDEVs. Our goal advance our encourage exploration PDEV-based science technology, offering insights potential applications human health.
Language: Английский
Citations
2