Thiobenzamide-based ruthenium complexes: chemical reactivity and promising biological investigations against Leukemia cancer cells DOI

Paulo G. F. Azevedo,

Luciano Vasconcellos Pacheco,

Felipe E. M. Carneiro

et al.

Transition Metal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: July 6, 2024

Language: Английский

Improvement of the Antioxidant and Antitumor Activities of Benzimidazole-Chitosan Quaternary Ammonium Salt on Drug Delivery Nanogels DOI Creative Commons
Bing Ma, Qing Li, Jingjing Zhang

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(1), P. 40 - 40

Published: Jan. 11, 2024

The present study focused on the design and preparation of acid-responsive benzimidazole-chitosan quaternary ammonium salt (BIMIXHAC) nanogels for a controlled, slow-release Doxorubicin HCl (DOX.HCl). BIMIXHAC was crosslinked with sodium tripolyphosphate (TPP) using ion crosslinking method. method resulted in low polydispersity index, small particle size, positive zeta potential values, indicating good stability nanogels. Compared to hydroxypropyl trimethyl chloride chitosan-Doxorubicin HCl-sodium (HACC-D-TPP) nanogel, salt-Doxorubicin (BIMIXHAC-D-TPP) nanogel show higher drug encapsulation efficiency loading capacity (BIMIXHAC-D-TPP 93.17 ± 0.27% 31.17 0.09%), release profiles accelerated vitro. chitosan-sodium (HACC-TPP), salt-sodium (BIMIXHAC-TPP) demonstrated favorable antioxidant capability. assay cell viability, measured by MTT assay, revealed that led significant reduction viability two cancer cells: human lung adenocarcinoma epithelial line (A549) breast (MCF-7). Furthermore, BIMIXHAC-D-TPP 2.96 times less toxic than DOX.HCl mouse fibroblast (L929). It indicated BIMIXHAC-based enhanced antitumor activities acidic-responsive could serve as nanocarrier.

Language: Английский

Citations

3
Boarding pyroptosis onto nanotechnology for cancer therapy DOI

Weiyue Ban,

Zhichao Chen,

Tao Zhang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 653 - 676

Published: May 15, 2024

Language: Английский

Citations

3
In vitro and In vivo anticancer activities of Bi(III) 2-thiazolecarboxaldehyde thiosemicarbazone complex DOI

Xiaoying Jia,

Jinhui Pang,

Yong Kyu Chu

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1318, P. 139389 - 139389

Published: July 23, 2024

Language: Английский

Citations

3
Liposomal Formulations of Metallodrugs for Cancer Therapy DOI Open Access
Eleonora Botter, Isabella Caligiuri, Flavio Rizzolio

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9337 - 9337

Published: Aug. 28, 2024

The search for new antineoplastic agents is imperative, as cancer remains one of the most preeminent causes death worldwide. Since discovery therapeutic potential cisplatin, study metallodrugs in chemotherapy acquired increasing interest. Starting from cisplatin derivatives, such oxaliplatin and carboplatin, last years, different compounds were explored, employing metal centers iron, ruthenium, gold, palladium. Nonetheless, face several drawbacks, low water solubility, rapid clearance, possible side toxicity. Encapsulation has emerged a promising strategy to overcome these issues, providing both improved biocompatibility protection payload degradation biological environment. In this respect, liposomes, which are spherical vesicles characterized by an aqueous core surrounded lipid bilayers, have proven be ideal candidates due their versatility. fact, they can encapsulate hydrophilic hydrophobic drugs, biocompatible, properties tuned improve selective delivery tumour sites exploiting passive active targeting. review, we report recent findings on liposomal formulations metallodrugs, with focus encapsulation techniques obtained results.

Language: Английский

Citations

3
Recent advances in the development of metallodrugs for cancer chemoimmunotherapy DOI

Fangmian Wei,

Jinzhe Liang, Xing‐Can Shen

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 526, P. 216319 - 216319

Published: Nov. 28, 2024

Language: Английский

Citations

3
Liposomes Containing Zinc-Based Chemotherapeutic Drug Block Proliferation and Trigger Apoptosis in Breast Cancer Cells DOI
Mallayasamy Siva, Kiran Das, Subhabrata Guha

et al.

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(12), P. 5310 - 5323

Published: Nov. 21, 2023

Platinum-based chemotherapeutic drugs are effective in killing malignant cells but often trigger drug resistance or off-target side effects. Unlike platinum, zinc is used as an endogenous cofactor for several cellular enzymes and may, thus, display increased biocompatibility. In this present study, we have rationally designed synthesized two substituted phenanthro[9,10-d]imidazole-based ligands L1 L2 with pyridine quinoline substitution at the 2 position their corresponding Zn(II) complexes; (L1)2Zn (L2)2Zn, which characterized by standard analytical spectroscopic methods. not has intrinsic fluorescence, indicating its potential utility imaging applications. To facilitate uptake, generated liposomal formations a phospholipid DMPC (1,2-Dimyristoyl-sn-glycero-3-phosphocholine) through molecular self-assembly. These formulations Lip-(L1)2Zn Lip-(L2)2Zn were able to enter breast cancer cells, induce DNA fragmentation, arrest cell cycle G0/G1 phase, decrease proliferation, promote apoptosis activating damage response. Importantly, both decreased size of cell-based spheroids, they may be capable suppressing tumor growth. Our work represents important proof-of-concept exercise demonstrating that successful formation complexes inherent optical properties great promise development probes efficient anticancer drugs.

Language: Английский

Citations

4
Insights into the antineoplastic activity and mechanisms of action of coumarin-coordinated 8-hydroxyquinoline ruthenium(II/III) compounds DOI

Ling-Qi Du,

Yan Yang, Li Ruan

et al.

Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 259, P. 112659 - 112659

Published: July 4, 2024

Language: Английский

Citations

1
Bio-molecular Fe(III) and Zn(II) complexes stimulate the interplay between PI3K/AKT1/EGFR inhibition and induce autophagy and apoptosis in epidermal skin cell cancer DOI
Aeshah A. Awaji, Heba W. Alhamdi,

Khulud Mohammed Alshehri

et al.

Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 262, P. 112720 - 112720

Published: Sept. 4, 2024

Language: Английский

Citations

1
Epigenetic remodeling under oxidative stress: Mechanisms driving tumor metastasis DOI Creative Commons

Peilan Peng,

Siyuan Qin, Lei Li

et al.

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(4)

Published: Nov. 14, 2024

Abstract Tumor metastasis is a multistep, inefficient process orchestrated by diverse signaling pathways. Compared to primary tumor cells, disseminated cells inevitably encounter higher oxidative stress in foreign environments. The levels of reactive oxygen species (ROS) fluctuate dynamically during different metastatic stages, adding complexity the regulation progression. Numerous studies suggest that epigenetic remodeling, key reversible mechanism gene regulation, plays critical role responding and controlling expression profiles drive metastasis. Despite extensive research, comprehensive understanding how impacts through modifications remains elusive, such as DNA methylation, histone modification, ncRNAs, m 6 A modification. Epigenetic therapeutic strategies, DNMT inhibitors, HDAC inhibitors (HDACis), miRNA mimics, have shown promise, yet challenges related immunogenicity, specificity, delivery also exist. Furthermore, due limited understanding, some drugs targeting modification be explored. In this review, we provided an overview influences behavior, summarized mechanisms involved these processes, reviewed latest advancements epigenetic‐targeted therapies, which may pave way develop novel strategy for preventing or treating

Language: Английский

Citations

1
Discovery of indole analogue Tc3 as a potent pyroptosis inducer and identification of its combination strategy against hepatic carcinoma DOI Creative Commons

Xiao Hu,

Xiaomei Tang,

Xiaoman Tian

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 15(4), P. 1285 - 1303

Published: Dec. 31, 2024

Rationale: Hepatic carcinoma, one of the most malignant cancers in world, has limited success with immunotherapy and a poor prognosis patients.While pyroptosis is considered as promising strategy for tumors, it still suffers from lack effective inducers.Methods: We designed, synthesized screened an indole analogue, Tc3, featuring 2, 4-thiazolidinedione substituted scaffold.Western blotting, qPCR immunofluorescence were employed to detect levels pathway induced by Tc3.RNA sequencing was used identify mechanisms Tc3 hepatic carcinoma.To validate anti-tumor effect we CDXs PDXs mouse models vivo.Then, syngeneic effects cisplatin anti-PD-1 antibody verified via western immunofluorescence, flow cytometry ELISA.Results: Treatment notably inhibited growth carcinoma both vitro vivo.Mechanistically, function PRDX1 up-regulated excessive ROS.Then, gasderminE-mediated activating endoplasmic reticulum stress.Tumor cells high expression GSDME achieved better responses Tc3-therapy.Tc3 also improved efficacy against carcinoma.Additionally, superior synergistic treatment observed when combined antibody.Notably, activated tumor immune microenvironment (TIME) enhanced CD8 + T cell infiltration carcinoma.Conclusions: Collectively, identified compound treating established its therapeutic inducer.

Language: Английский

Citations

1