Abstract
A
photocatalytic
methodology
has
been
devised
for
the
stereoselective
construction
of
trisubstituted
alkenes
incorporating
3,3‐difluoro‐γ‐lactams
in
17–93%
yields
via
a
radical
cascade
process
utilizing
MBH
acetates
and
N
‐allylbromodifluoroacetamides
as
starting
materials.
The
reaction
mechanism
involves
single‐electron
transfer,
5
‐
exo
trig
cyclization,
addition,
elimination
fashion.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(14), P. 2466 - 2470
Published: March 31, 2023
A
novel
and
green
photocatalytic
strategy
for
the
synthesis
of
C-4-acylated
coumarins
with
α-keto
acids
3-nitrocoumarin
has
been
developed.
This
operationally
simple
protocol
works
under
mild
reaction
conditions,
providing
convenient
access
to
4-acyl
coumarin
derivatives.
The
control
experimental
results
showed
that
nitro
radical
produced
by
cleavage
C-N
bond
acts
as
an
electron
acceptor
complete
cycle,
achieving
a
redox-neutral
reaction.
New Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
47(22), P. 10744 - 10750
Published: Jan. 1, 2023
A
photocatalyst-free
visible-light-promoted
tandem
intramolecular
cyclization/heteroarylation
between
bromodifluoroacetamides
and
quinoxalin-2(1
H
)-ones
or
coumarins
was
developed.
The
process
could
generate
a
broad
range
of
α
,
-difluoro-γ-lactams.
Helvetica Chimica Acta,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Abstract
The
integration
of
sustainable
practices,
such
as
employing
renewable
light
sources
for
synthesizing
valuable
synthetic
scaffolds,
has
been
progressing
over
the
past
few
decades.
Among
these
noteworthy
organic
frameworks,
lactams,
particularly
γ‐lactams,
have
established
their
prominence
due
to
extensive
applications
in
pharmaceutical,
agricultural,
and
medicinal
domains.
This
growing
significance
γ‐lactams
spurred
considerable
interest
synthesis,
especially
via
milder,
more
sustainable,
environmentally
friendly
methods.
In
recent
years,
numerous
innovative
reaction
mechanisms
explored,
highlighting
how
photocatalysis
can
enable
formation
from
readily
accessible
precursors
through
C−N
bond
cyclization
processes.
review
emphasizes
potential
photocatalytic
strategies
not
only
enhance
current
methods
but
also
foster
development
greener
chemical
processes
future.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(47), P. 8535 - 8539
Published: Nov. 20, 2023
A
novel
method
for
the
nickel-catalyzed
multicomponent
aminofluoroalkylation/cyclization
of
styrenes
with
ethyl
fluoroacetate
and
anilines
has
been
developed.
This
protocol
provides
general
efficient
access
to
a
diverse
range
fluoro-γ-lactams
from
simple
readily
available
starting
materials.
Control
experiments
prove
involvement
radical
intermediates
excluded
presence
2-fluoro-N-phenylacetamide.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
26(3), P. 1223 - 1280
Published: Dec. 18, 2023
By
harnessing
the
reactivity
of
alkynes
and
alkenes
under
photochemical
conditions,
novel
pathways
have
been
unlocked
to
construct
N
-heterocyclic
compounds,
allowing
for
more
efficient
sustainable
synthesis.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(46), P. 9903 - 9908
Published: Nov. 8, 2024
This
manuscript
describes
the
application
of
a
1,5-hydrogen
atom
transfer
strategy
in
photoredox-catalyzed
hydrodifluoroalkylation
alkynes.
The
approach
utilizes
sequential
cascade
process
difluoroalkylation,
transfer,
C(sp
Asian Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
12(8)
Published: July 8, 2023
Abstract
Sulfonamide
is
one
of
the
most
important
structures
in
organic
chemistry
due
to
its
frequent
appearance
natural
products
as
well
pharmaceuticals.
This
study
reports
a
visible‐light‐promoted
strategy
for
synthesis
sulfonamides
from
arylazo
sulfones.
One‐pot
tri‐component
reactions
were
conducted
using
sulfones,
DABSO,
and
amines
presence
CuBr
2
coupling
catalyst
under
irradiation
with
blue
LEDs
prepare
various
good
yields
mild
conditions.
method
could
be
used
effectively
produce
variety
useful
sulfonamides.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(24), P. 4507 - 4512
Published: Nov. 3, 2023
Abstract
An
electrochemical
Reformatsky‐type
reaction
of
bromodifluoroamides
with
aldehydes/ketones
via
electron
reductive
umpolung
is
reported,
leading
to
the
generation
a
series
β‐hydroxy‐α,α‐difluoro
amides
in
moderate
good
yields.
This
protocol
tolerated
variety
commercially
available
alkyl
ketone,
and
aromatic
aldehydes,
featuring
broad
substrate
scope
functional
group
tolerance
under
transition
metal‐free
conditions
without
metal
reduction
reagents.
Control
experiment
indicated
that
proceeded
an
pathway.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(42), P. 8437 - 8452
Published: Jan. 1, 2024
Herein
we
demonstrate
that
a
visible-light-induced
photocatalytic
four-component
fluoroalkylation-dithiocarbamylation
is
unified
method
for
the
fluoroalkylation
of
diverse
activated
fluoroalkyl
halides,
including
monofluoroalkyl
bromides,
difluoroalkyl
trifluoromethyl
iodide,
and
perfluoroalkyl
iodides.
The
synthetic
value
this
has
been
demonstrated
by
transformations
various
substrates
containing
drug/natural
product
skeletons,
gram
scale
reactions,
further
derivatizations
fluorodithiocarbamate
products.
This
work
features
an
atom
economical
protocol
simple
to
operate,
does
not
require
any
additives
or
strong
bases,
can
be
carried
out
under
mild
conditions.
