Asian Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 9, 2024
Abstract
A
Sc(OTf)
3
‐catalyzed
tandem
cyclization
reaction
of
o
‐hydroxyphenyl
enaminones
with
1,3,5‐triazinanes
has
been
developed
to
generate
two
distinct
annulated
products
in
moderate
good
yields,
which
is
dominated
by
the
electronic
characteristics
1,3,5‐triazinanes.
The
1,3,5‐triaryl‐1,3,5‐triazinane
reacted
as
C−N
synthon
produce
C3‐aminomethyl
chromone,
while
1,3,5‐trialkyl‐1,3,5‐triazinane
acted
C−N−C−N
synthons
deliver
N
,
‐dialkyl
tetrahydropyrimidine
a
free
hydroxyl
group.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(9), P. 5459 - 5520
Published: April 28, 2023
Biocatalysis
has
revolutionized
chemical
synthesis,
providing
sustainable
methods
for
preparing
various
organic
molecules.
In
enzyme-mediated
most
reactions
involve
molecules
operating
from
their
ground
states.
Over
the
past
25
years,
there
been
an
increased
interest
in
enzymatic
processes
that
utilize
electronically
excited
states
accessed
through
photoexcitation.
These
photobiocatalytic
a
diverse
array
of
reaction
mechanisms
are
complementary
to
one
another.
This
comprehensive
review
will
describe
state-of-the-art
strategies
photobiocatalysis
synthesis
until
December
2022.
Apart
reviewing
relevant
literature,
central
goal
this
is
delineate
mechanistic
differences
between
general
employed
field.
We
organize
based
on
relationship
photochemical
step
and
transformations.
The
include
studies,
substrate
scopes,
protein
optimization
strategies.
By
clearly
defining
mechanistically-distinct
chemistry,
we
hope
illuminate
future
synthetic
opportunities
area.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(10), P. 2363 - 2369
Published: March 16, 2024
Abstract
A
synthetic
protocol
was
developed
to
synthesize
highly
functionalized
3‐furylmethyl
chromones
from
enynones
and
o
‐hydroxyphenyl
enaminones
via
silver‐catalyzed
cascade
bis‐heteroannulation
reaction.
This
strategy
features
broad
substrate
scope
good
functional
group
tolerance.
Furthermore,
the
chromone
skeleton
shows
potential
application
value
through
further
gram‐scale
synthesis
derivatization.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(21), P. 2958 - 2961
Published: Jan. 1, 2024
Visible-light-driven
EDA
complex-promoted
ring-opening
of
cycloketone
oxime
esters
to
synthesise
various
4-cyanoalkylated
isoquinoline-1,3-diones
with
acryloylbenzamides
was
developed.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(6), P. 4017 - 4023
Published: March 2, 2023
A
facile
cascade
reaction
for
the
site
selective
synthesis
of
2-cyanochromones
is
described.
By
using
simple
o-hydroxyphenyl
enaminones
and
potassium
ferrocyanide
trihydrate
(K4[Fe(CN)6]3·3H2O)
as
starting
materials
I2/AlCl3
promoters,
products
are
furnished
via
tandem
chromone
ring
formation
C–H
cyanation.
The
in
situ
3-iodochromone
a
formal
1,2-hydrogen
atom
transfer
(HAT)
process
account
unconventional
selectivity.
In
addition,
2-cyanoquinolin-4-one
has
been
realized
by
employing
corresponding
2-aminophenyl
enaminone
substrate.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(28)
Published: May 1, 2024
Abstract
An
electrochemical
decarboxylative
addition
of
N
‐substituted
glycines
to
enaminones
has
been
developed
and
conducted
under
oxidant‐,
catalyst‐,
light‐free
conditions
in
acetonitrile
at
room
temperature
by
using
electron
as
the
traceless
oxidant,
which
provided
a
green
approach
access
C3‐aminomethyl
chromones.
The
resulting
products
were
formed
through
radical
addition/oxidation/cyclization
or
electrophilic
addition/cyclization
pathway
could
act
valuable
building
blocks
construct
polysubstituted
pyrimidine
derivatives.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
22(4), P. 784 - 789
Published: Dec. 20, 2023
The
synthesis
of
quinazolinones
via
a
visible
light-mediated
reaction
benzyl
bromides
with
2-aminobenzamides
is
reported,
and
the
HBr
generated
during
first
step
promoted
subsequent
step.
