Advanced Synthesis & Catalysis,
Journal Year:
2019,
Volume and Issue:
361(8), P. 1896 - 1901
Published: Feb. 11, 2019
Abstract
An
efficient
method
for
the
synthesis
of
substituted
1(2
H
)‐isoquinolone
derivatives
via
nickel‐catalyzed
annulation
2‐halobenzamidines
with
aryl
alkynes
in
presence
water
is
described.
Benzo[4,5]imidazo[2,1‐
a
]isoquinolines
were
formed
as
dominated
products
when
dry
dimethyl
sulfoxide
was
used
solvent.
Furthermore,
benzyl
amidines
substrates,
debenzylation
reaction
occured
to
provide
various
1‐aminoisoquinoline
products.
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image
Advanced Synthesis & Catalysis,
Journal Year:
2020,
Volume and Issue:
362(18), P. 3795 - 3823
Published: May 18, 2020
Abstract
The
synthetic
methodology
for
direct
indole
functionalizations
is
of
great
significance
in
chemistry
and
has
been
intensively
investigated
the
last
few
decades.
From
perspective
green
chemistry,
oxygen
best
choice
as
terminal
oxidant
molecular
synthesis.
Hence,
aerobic
oxidative
functionalization
indoles
became
a
hot
research
topic
decade.
Numerous
efficient
protocols
this
field
have
discovered
that
enable
facile
transformations
to
related
valuable
compounds,
which
are
summarized
discussed
detail
review.
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image
Organic Chemistry Frontiers,
Journal Year:
2021,
Volume and Issue:
8(11), P. 2710 - 2771
Published: Jan. 1, 2021
This
review
presents
a
critical
and
authoritative
analysis
of
several
exciting
benzannulation
approaches
developed
in
the
past
decade
for
construction
carbazoles,
indolocarbazoles,
benzocarbazoles,
carbolines.
Organic Letters,
Journal Year:
2018,
Volume and Issue:
20(14), P. 4285 - 4289
Published: July 6, 2018
A
three-component
reaction
of
indoles,
α-bromoacetaldehyde
acetals,
and
ketones
was
developed
by
using
bismuth(III)
triflate
as
the
catalyst
to
realize
a
straightforward
approach
for
synthesizing
carbazole
derivatives.
The
established
mechanistically
through
autotandem
catalysis
Bi(OTf)3
in
following
two
steps:
(i)
Friedel–Crafts-type
alkylation
indole
with
acetal,
which
produced
tryptaldehyde-type
intermediate
(ii)
[4
+
2]
annulation
this
ketone
component.
Advanced Synthesis & Catalysis,
Journal Year:
2017,
Volume and Issue:
359(24), P. 4300 - 4304
Published: Oct. 3, 2017
Abstract
A
Bronsted
acid
promoted
three‐component
synthesis
of
substituted
thieno[2,3‐
b
]indole
has
been
developed
starting
from
indoles,
alkenes
or
alkynes,
and
sulfur
powder.
N
,
‐Dimethylformamide
plays
an
important
role
to
convert
the
materials
into
fused
products.
Various
functional
groups
attached
substrates
were
well
tolerated
afford
corresponding
products
in
moderate
good
yields
under
very
simple
reaction
conditions.
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image
Advanced Synthesis & Catalysis,
Journal Year:
2017,
Volume and Issue:
359(11), P. 1860 - 1866
Published: April 13, 2017
Abstract
Benzannulation
of
2‐alkenylindoles
with
readily
available
aldehydes,
under
one‐pot
sequential
triple‐relay‐catalysis,
provides
an
easy
access
to
several
structurally
unique
carbazoles
including
2‐
and
3‐alkenylcarbazoles.
This
protecting
group‐free
method
enabled
synthesis
alkaloids
such
as
hyellazole
6‐chlorohyellazole,
the
formal
syntheses
seven
other
alkaloids.
Construction
core
structure,
present
in
murastifoline
A,
murrafoline
E,
related
was
also
demonstrated.
Even
conjugated
3,3′‐biscarbazoles
can
be
synthesized
by
one‐pot,
two‐fold
triple‐relay
catalysis
.
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image
Organic & Biomolecular Chemistry,
Journal Year:
2019,
Volume and Issue:
18(1), P. 163 - 168
Published: Dec. 2, 2019
The
CuSO4
catalyzed
three-component
reaction
of
indole-2-acetate,
aromatic
aldehydes
and
3-methyleneoxindoles
in
toluene
at
130
°C
afforded
polysubstituted
spiro[carbazole-3,3'-indolines]
good
yields
with
high
diastereoselectivity.
When
isatylidene
malononitriles
were
used
as
dienophiles,
regio-isomeric
spiro[carbazole-2,3'-indolines]
selectively
obtained.
A
similar
2-arylidene-1,3-indanediones
resulted
spiro[carbazole-3,2'-indenes]
satisfactory
stereochemistry
the
diastereoisomers
spiro
compounds
was
clearly
elucidated
by
analysis
NMR
spectra
determination
fourteen
single
crystal
structures.
mechanism
included
formation
reactive
2,3-dimethyleneindoline
a
sequential
Diels-Alder
reaction.
Organic Letters,
Journal Year:
2019,
Volume and Issue:
21(10), P. 3518 - 3522
Published: May 6, 2019
An
efficient
three-component
benzoselenophenes
formation
has
been
developed
from
substituted
indoles,
acetophenones,
and
selenium
powder
under
metal-free
conditions.
2-Aryl
indoles
played
an
important
role
to
promote
benzoselenophene
acetophenone
derivatives
powder.
One
C–C
two
C–Se
bonds
were
selectively
formed
provide
40
new
in
good
yields.
Organic & Biomolecular Chemistry,
Journal Year:
2021,
Volume and Issue:
19(29), P. 6380 - 6391
Published: Jan. 1, 2021
Cyclohexanone
is
a
simple
and
widely
available
raw
material
that
can
be
obtained
from
lignin
biomass,
highlighting
its
renewable
sustainable
features.
Cyclohexanone,
as
an
important
synthon
in
organic
chemistry,
has
been
demonstrated
to
viable
for
constructing
functionalized
arenes
benzoheteroarenes,
with
recent
extensive
development
on
transition
metal-free
oxidative
dehydrogenative
aromatization.
This
review
focuses
research
progress
the
derivation
of
cyclohexanones
via
