Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: 45(17)

Published: May 28, 2024

Stimuli-responsive low molecular weight hydrogel interventions for Biomedical challenges are a rapidly evolving paradigm in the bottom-up approach recently. Peptide-based self-assembled nano biomaterials present safer alternatives to their non-degradable counterparts as demanded today's most urged clinical needs.Although plethora of work has already been accomplished, programming hydrogelators with appropriate functionalities requires better understanding impact macromolecular structure peptides and subsequently, nanostructures remain unidentified. Henceforth this review focuses on two aspects: Firstly, underlying guidelines building biomimetic strategies tailor scaffolds leading hydrogelation along role non-covalent interactions that key components various self-assembly processes. In second section, it is aimed bring together recent achievements designer assembly concerning self-aggregation behaviour applications mainly biomedical arena like drug delivery carrier design, antimicrobial, anti-inflammatory well wound healing materials. Furthermore, anticipated article will provide conceptual demonstration different approaches taken towards construction these task-specific hydrogels. Finally, collective effort among material scientists required pave path entrance intelligent materials into medicine from bench bedside.

Language: Английский