Advances in medical technologies and clinical practice book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 219 - 236
Published: Nov. 29, 2024
The
old
procedures
of
the
conventional
histology
process
continue
to
limit
pathologists.
Bone
structure
is
complex,
which
makes
diagnosis
difficult.
To
improve
diagnostic
capacities
using
CAD
tools,
digital
histopathology
must
be
used.
development
automated
techniques
needs
investigation
based
on
various
facets
bone
structure.
assess
tumor
density
methods
have
been
created
still
image
classification
remains
a
considerable
address
this
issue,
Convolutional
algorithm
used
for
identifying
different
types
cancer
images.
differentiate
between
healthy
&
damaged
sections,
our
approach
combines
important
classifiers
and
applies
Karhunen-Loeve
extraction
method
certain
picture
attributes.
results
found
are
subsequently
fed
with
help
ML
enhance
accuracy
i.e.
97.3%
detection
prediction.
proposed
method,
algorithms
histopathological
analysis,
provides
promising
increase
effectiveness
identification
Materials,
Journal Year:
2023,
Volume and Issue:
16(12), P. 4483 - 4483
Published: June 20, 2023
Tissue
regeneration
of
large
bone
defects
is
still
a
clinical
challenge.
Bone
tissue
engineering
employs
biomimetic
strategies
to
produce
graft
composite
scaffolds
that
resemble
the
extracellular
matrix
guide
and
promote
osteogenic
differentiation
host
precursor
cells.
Aerogel-based
scaffold
preparation
methods
have
been
increasingly
improved
overcome
difficulties
in
balancing
need
for
an
open
highly
porous
hierarchically
organized
microstructure
with
compression
resistance
withstand
physiological
loads,
especially
wet
conditions.
Moreover,
these
aerogel
implanted
vivo
critical
defects,
order
test
their
potential.
This
review
addresses
recently
published
studies
on
(organic/inorganic)-based
scaffolds,
having
mind
various
cutting-edge
technologies
raw
biomaterials
used,
as
well
improvements
are
challenge
terms
relevant
properties.
Finally,
lack
3D
vitro
models
emphasized,
further
developments
minimize
requirement
using
animal
models.
Medical Review,
Journal Year:
2024,
Volume and Issue:
5(1), P. 1 - 22
Published: July 5, 2024
Abstract
Bone
injuries
and
diseases
are
associated
with
profound
changes
in
the
biophysical
properties
of
living
bone
tissues,
particularly
their
electrical
mechanical
properties.
The
healthy
attributed
to
complex
network
interactions
between
its
various
cell
types
(i.e.,
osteocytes,
osteoclast,
immune
cells
vascular
endothelial
cells)
surrounding
extracellular
matrix
(ECM)
against
backdrop
a
myriad
biomechanical
bioelectrical
stimuli
arising
from
daily
physical
activities.
Understanding
pathophysiological
is
critical
developing
new
therapeutic
strategies
novel
scaffold
biomaterials
for
orthopedic
surgery
tissue
engineering,
as
well
provides
basis
application
agents
restore
physiological
microenvironment
injured/diseased
tissue,
facilitate
repair
regeneration.
These
include
mechanical,
electrical,
magnetic,
thermal
ultrasound
stimuli,
which
will
be
critically
examined
this
review.
A
significant
advantage
utilizing
such
healing
that
these
may
applied
non-invasively
minimal
damage
unlike
conventional
surgical
procedures.
Furthermore,
effects
can
localized
specifically
at
defect
site,
drugs
or
growth
factors
tend
diffuse
away
after
delivery,
result
detrimental
side
ectopic
sites.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Abstract
Photothermal
hydrogels
(PTHs)
are
considered
next‐generation
biomaterials
as
they
offer
remotely
defined
biophysical
information
of
the
extracellular
milieu.
PTHs
allow
precise
and
non‐genetic
control
for
regeneration
native
tissues,
which
is
ultimate
goal
tissue
engineering
(TE).
Molecular
physical
properties
PTHs,
such
components,
structural
configurations,
mechanical
characteristics,
collectively
serve
determinants
understanding
dynamic
response
clinical
translation.
have
entered
a
period
fruition
due
to
development
numerous
manufacturing
technologies
polymeric
matrices.
Herein,
this
review
comprehensively
meticulously
elucidates
mechanisms
regenerative
therapeutics
underlying
design
fabrication
PTHs.
Recent
advances
in
photothermal
principles
various
categories
agents
(PTAs)
been
extensively
discussed.
Vital
components
structures
summarized
enable
efficacious
therapeutic
energy
delivery.
Emerging
applications
TE
also
demonstrated,
expand
strategies
intrinsic
injured
tissues.
Then
deliberate
chemical
enhance
prognosis
while
highlighting
challenges
associated
with
In
review,
we
aim
provide
guidance
prospects
exploration
innovation
field
TE.
Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Postoperative
treatment
of
osteosarcoma
is
one
the
major
challenging
clinical
issues
since
both
elimination
residual
tumors
and
acceleration
bone
regeneration
should
be
considered.
Photothermal
therapy
has
been
widely
studied
due
to
its
advantages
small
side-effect,
low-toxicity,
high
local
selectivity
noninversion,
tissue
engineering
an
inevitable
trend
in
postoperative
osteosarcoma.
In
this
study,
we
combined
photothermal
together,
developed
a
kind
multifunctional
nanofibrous
3D
matrixes
for
The
flexible
bioactive
glass
nanofibers
(BGNFs)
prepared
by
sol-gel
electrospinning
calcination
acted
as
basic
blocks,
genipin-crosslinked
gelatin
(GNP-Gel)
cement
bond
BGNFs
forming
stable
structure.
porous
scaffolds
were
obtained
through
ice
crystal
templating
method
freeze-drying
technology.
GNP-Gel/BGNF
showed
structure
that
highly
biomimetics
extracellular
matrix.
excellent
compression
recovery
performance
water
these
made
them
suitable
minimally
invasive
surgery.
addition,
not
only
biocompatible
vitro,
but
also
benefit
formation
mineralized
vivo.
Furthermore,
dark
blue
GNP-Gel
agent,
which
endowed
with
efficient
antitumor
antibacterial
without
addition
other
toxic
agents.
Therefore,
study
provides
ingenious
avenue
prepare
Advances in medical technologies and clinical practice book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 219 - 236
Published: Nov. 29, 2024
The
old
procedures
of
the
conventional
histology
process
continue
to
limit
pathologists.
Bone
structure
is
complex,
which
makes
diagnosis
difficult.
To
improve
diagnostic
capacities
using
CAD
tools,
digital
histopathology
must
be
used.
development
automated
techniques
needs
investigation
based
on
various
facets
bone
structure.
assess
tumor
density
methods
have
been
created
still
image
classification
remains
a
considerable
address
this
issue,
Convolutional
algorithm
used
for
identifying
different
types
cancer
images.
differentiate
between
healthy
&
damaged
sections,
our
approach
combines
important
classifiers
and
applies
Karhunen-Loeve
extraction
method
certain
picture
attributes.
results
found
are
subsequently
fed
with
help
ML
enhance
accuracy
i.e.
97.3%
detection
prediction.
proposed
method,
algorithms
histopathological
analysis,
provides
promising
increase
effectiveness
identification
