Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(36), P. 7287 - 7306
Published: Jan. 1, 2024
Synthetic
glycopeptides
capable
of
self-assembly
in
aqueous
environments
form
a
range
supramolecular
nanostructures,
such
as
nanoparticles
and
nanofibers,
owing
to
their
amphiphilic
nature
the
diverse
structures
saccharides
introduced.
These
glycopeptide-based
materials
are
promising
for
immunotherapy
applications
because
biocompatibility
multivalent
saccharide
display,
which
enhances
lectin-saccharide
interactions.
This
review
highlights
recent
advances
molecular
design
synthetic
use
immunomodulatory
agents.
Materials,
Journal Year:
2024,
Volume and Issue:
17(19), P. 4792 - 4792
Published: Sept. 29, 2024
Hydrogels,
known
for
their
unique
ability
to
retain
large
amounts
of
water,
have
emerged
as
pivotal
materials
in
both
tissue
engineering
and
biosensing
applications.
This
review
provides
an
updated
comprehensive
examination
cutting-edge
hydrogel
technologies
multifaceted
roles
these
fields.
Initially,
the
chemical
composition
intrinsic
properties
natural
synthetic
hydrogels
are
discussed,
highlighting
biocompatibility
biodegradability.
The
manuscript
then
probes
into
innovative
scaffold
designs
fabrication
techniques
such
3D
printing,
electrospinning,
self-assembly
methods,
emphasizing
applications
regenerating
bone,
cartilage,
skin,
neural
tissues.
In
realm
biosensing,
hydrogels’
responsive
nature
is
explored
through
integration
optical,
electrochemical,
piezoelectric
sensors.
These
sensors
instrumental
medical
diagnostics
glucose
monitoring,
pathogen
detection,
biomarker
identification,
well
environmental
industrial
like
pollution
food
quality
monitoring.
Furthermore,
explores
cross-disciplinary
innovations,
including
use
wearable
devices,
hybrid
systems,
potential
personalized
medicine.
By
addressing
current
challenges
future
directions,
this
aims
underscore
transformative
impact
advancing
healthcare
practices,
thereby
providing
a
vital
resource
researchers
practitioners
field.
Nanomedicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 9
Published: Feb. 12, 2025
Opioid
poisoning,
also
known
as
opioid
overdose
or
toxicity,
is
a
medical
emergency
where
there
excessive
binding
of
opioids
to
mu-opioid
receptors,
leading
analgesia,
sedation,
and
respiratory
depression.
Naloxone
currently
the
recommended
treatment
for
reversing
poisoning;
however,
it
has
limitations,
such
shorter
half-life
than
most
opioids,
which
can
lead
renarcotization.
Multiple
nanoparticle
(NP)
formulations
have
addressed
this
limitation
by
exhibiting
longer
well
successfully
antagonizing
effects
opioids.
This
review
explores
polymer-,
lipid-,
peptide-based
NP
formulations,
been
studied
alternatives
naloxone.
NP-naloxone
potential
implementation
into
clinical
practice,
yet
their
realization
hinges
on
investment
in
research.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(46)
Published: June 14, 2024
Supramolecular
hydrogels
play
a
pivotal
role
in
many
fields
of
biomedical
research,
including
emerging
applications
designing
advanced
tools
for
point-of-care
testing,
clinical
diagnostics,
and
lab-on-chip
analysis.
This
review
outlines
the
growing
relevance
supramolecular
biosensing
bioassay
devices,
highlighting
recent
advancements
that
deliver
increased
sensitivity,
real-time
monitoring,
multiplexing
capabilities
through
distinctive
properties
these
nanomaterials.
Furthermore,
exploration
extends
to
additional
applications,
such
as
using
three-dimensional
matrices
cell-based
assays.
Gels,
Journal Year:
2024,
Volume and Issue:
10(8), P. 507 - 507
Published: Aug. 1, 2024
Self-assembled
peptide-based
hydrogels
have
attracted
considerable
interest
from
the
research
community.
Particularly,
low
molecular
weight
gelators
(LMWGs)
consisting
of
amino
acids
and
short
peptides
are
highly
suitable
for
biological
applications
owing
to
their
facile
synthesis
scalability,
as
well
biocompatibility,
biodegradability,
stability
in
physiological
conditions.
However,
challenges
understanding
structure–property
relationship
lack
design
rules
hinder
development
new
with
required
properties
several
applications.
Hereby,
plethora
gelators,
this
review
discusses
mechanical
single
acid
dipeptide-based
hydrogels.
A
mutual
analysis
these
systems
allows
us
highlight
between
gel
sequence,
preparation
methods,
or
N
capping
groups.
Additionally,
recent
advancements
tuning
gels’
rheological
reviewed.
In
way,
present
aims
help
bridge
knowledge
gap
structure
properties,
easing
selection
Langmuir,
Journal Year:
2024,
Volume and Issue:
40(46), P. 24405 - 24418
Published: Oct. 24, 2024
Short
peptide
assemblies
that
form
supramolecular
hydrogels
are
stabilized
by
both
intermolecular
noncovalent
interactions
among
amino
acid
side
chains
and
hydrogen
bonding
between
backbone
amides.
Previous
research
has
emphasized
the
inclusion
of
aromatic
acids
in
short
sequences,
positing
π-π
contribute
significantly
to
inducing
efficient
hydrogelation
i.e.,
at
low
minimum
gelation
concentrations
(MGCs).
However,
herein,
we
demonstrate
additional
from
play
a
more
pivotal
role
efficiency
compared
interactions.
We
investigated
two
sets
Fluorenylmethoxycarbonyl
(Fmoc)-functionalized
α-synuclein
human
islet
amyloid
fragments
[Fmoc-NVGGAVVT
(Syn-N)
Fmoc-NFGAIL
(IAP-N)],
substituting
asparagine
(N)
with
phenylalanine
(Syn-F/IAP-F),
alanine
(Syn-A/IAP-A),
glutamine
(Syn-Q/IAP-Q).
This
allowed
us
explore
effects
(π-system),
aliphatic
(hydrophobic),
varying
chain
lengths
on
hydrogel
formation.
Our
results
reveal
Syn-N
Syn-Q
exhibit
MGC
0.03
0.05
wt
%,
respectively,
classifying
them
as
super
hydrogelators
(MGC
<
0.1
%).
These
values
4.0-6.6-fold
lower
than
Syn-F
Syn-A,
demonstrating
greater
Syn-Q.
Similarly,
IAP-N
exhibited
substantial
decrease
8.75,
3.75,
2.5
folds
IAP-A,
IAP-F,
IAP-Q,
respectively.
Experimental
evidence
molecular
dynamic
simulation
suggest
-CO-NH
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
663, P. 124562 - 124562
Published: Aug. 5, 2024
The
aim
of
this
study
was
the
evaluation
suitability
novel
mucoadhesive
hydrogel
platforms
for
delivery
therapeutics
useful
management
disorders
related
to
gastrointestinal
tract
(GI).
At
purpose,
here
we
describe
preparation,
physicochemical
characterization
and
drug
behaviour
hydrogels,
based
on
self-assembling
lipopeptides
(MPD02-09),
obtained
by
covalently
conjugating
lauric
acid
(LA)
SNA's
peptide
derivatives
gotten
variously
combining
D-
L-
amino
residues.
LA
conjugation
aimed
at
improving
stability
precursor
peptides,
obtaining
amphiphilic
structures,
triggering
hydrogels
formation
through
self-assembling.
Budesonide
(BUD),
an
anti-inflammatory
drug,
selected
as
model
because
its
use
in
treatment
GI
disorders.
Preliminary
studies
were
performed
correlate
chemical
structure
conjugates
with
key
properties
materials
delivery.
Two
lipopeptides,
MPD03
MPD08,
found
form
(MPD03h
MPD08h,
respectively)
characteristics
suitable
These
showed
mucoadhesiveness
about
60
%.
In
vitro
carried
out
BUD
loaded
70
%
release
within
6
h.
Wound
healing
assessed
Caco-2
HaCaT
cells,
reduction
cell-free
area
values
lower
than
10
Taking
together
these
results
MPD03h
MPD08h
have
been
shown
be
excellent
candidates
