Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(40)

Published: Aug. 17, 2023

Abstract Although immunotherapy has a broad clinical application prospect, it is still hindered by low immune responses and immunosuppressive tumor microenvironment. Herein, simple drug‐free inorganic nanomaterial, alkalescent sodium bicarbonate nanoparticles (NaHCO 3 NPs), prepared via fast microemulsion method for amplified cancer immunotherapy. The obtained NaHCO regulates lactic acid metabolism through acid‐base neutralization so as to reverse the mildly acidic environment. Additionally, can further release high amounts of Na + ions inside cells induce surge in intracellular osmolarity, thus activate pyroptosis pathway immunogenic cell death (ICD), damage‐associated molecular patterns (DAMPs) inflammatory factors, improve responses. Collectively, NPs observably inhibit primary/distal growth metastasis remitted immunosuppression induced activation, showing an enhanced antitumor immunity efficiency. This work provides new paradigm mediated treatment, which potential

Language: Английский

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Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example

Small Methods, Journal Year: 2023, Volume and Issue: 7(5)

Published: Jan. 27, 2023

Abstract Programmed cell death (PCD, mainly including apoptosis, necrosis, ferroptosis, pyroptosis, and autophagy) immunogenic (ICD), as important mechanisms, are widely reported in cancer therapy, understanding the relationship between two is significant for clinical tumor treatments. Considering that vast nanodrugs developed to induce PCD ICD simultaneously, this review, interrelationship described using nanomedicines examples. First, an overview of patterns focus on morphological differences interconnections among them provided. Then apoptosis terms endoplasmic reticulum stress by introducing various treatments recent developments with inducible immunogenicity. Next, crosstalk non‐apoptotic (including signaling pathways introduced their through examples further illustrated. Finally, its application prospects development new nanomaterials summarized. This review believed deepen ICD, extend biomedical applications nanodrugs, promote progress therapy.

Language: Английский

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Delivering metal ions by nanomaterials: Turning metal ions into drug-like cancer theranostic agents

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 494, P. 215332 - 215332

Published: July 17, 2023

Language: Английский

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Multifunctional Calcium–Manganese Nanomodulator Provides Antitumor Treatment and Improved Immunotherapy via Reprogramming of the Tumor Microenvironment

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15449 - 15465

Published: Aug. 2, 2023

Ions play a vital role in regulating various biological processes, including metabolic and immune homeostasis, which involves tumorigenesis therapy. Thus, the perturbation of ion homeostasis can induce tumor cell death evoke responses, providing specific antitumor effects. However, strategies that exploit effects multiion are rare. We herein prepared pH-responsive nanomodulator by coloading curcumin (CU, Ca

Language: Английский

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Chiral polypeptide nanoparticles as nanoadjuvants of nanovaccines for efficient cancer prevention and therapy

Science Bulletin, Journal Year: 2023, Volume and Issue: 68(3), P. 284 - 294

Published: Jan. 19, 2023

Language: Английский

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