Nanomedicine Remodels Tumor Microenvironment for Solid Tumor Immunotherapy

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(15), P. 10217 - 10233

Published: April 2, 2024

Although immunotherapy is relatively effective in treating hematological malignancies, their efficacy against solid tumors still suboptimal or even noneffective presently. Compared to cancers, exhibit strikingly different immunosuppressive microenvironment, severely deteriorating the of immunotherapy: (1) chemical features such as hypoxia and mild acidity suppress activity immune cells, (2) pro-tumorigenic domestication cells microenvironment within further undermines effectiveness immunotherapy, (3) dense physical barrier tumor tissues prevents intratumoral infiltration contact killing active cells. Therefore, we believe that reversing are critical priority for tumors. Due unique morphologies, structures, compositions, nanomedicines have become powerful tools achieving this goal. In Perspective, will first briefly introduce then summarize most recent progresses nanomedicine-based by remodeling immune-microenvironment a comprehensive manner. It highly expected Perspective aid advancing tumors, optimistic on future development burgeoning field.

Language: Английский

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Oxygen‐Vacancy‐Engineered W₁₈O_49−x Nanobrush with a Suitable Band Structure for Highly Efficient Sonodynamic Therapy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(9)

Published: Jan. 12, 2024

With the rapid development of external minimally invasive or noninvasive therapeutic modalities, ultrasound-based sonodynamic therapy (SDT) is a new alternative for treating deep tumors. However, inadequate sonosensitizer efficiency and poor biosecurity limit clinical applications. In this study, we prepared an oxygen-vacancy-engineered W

Language: Английский

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Succinate Nanomaterials Boost Tumor Immunotherapy via Activating Cell Pyroptosis and Enhancing MHC-I Expression

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Despite the promising clinical applications of immunotherapy, its effectiveness is often limited by low immune responses and tumor escape. In this study, we introduce a simple drug-free inorganic nanomaterial, sodium succinate (C4H4Na2O4 NPs), prepared using rapid microemulsion method to enhance cancer immunotherapy. The synthesized C4H4Na2O4 NPs can release high concentrations Na+ ions into cells, leading an increase in intracellular osmolarity. This triggers pyroptosis pathway, resulting cellular contents, inflammatory factors, damage-associated molecular patterns, which ultimately boost responses. Furthermore, inhibit escape through upregulating major histocompatibility complex-I (MHC-I) expression. Collectively, significantly growth metastasis pyroptosis-induced activation MHC-I expression upregulation-remitted research offers novel approach treatment that leverages pyroptosis, demonstrating potential for application

Language: Английский

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Design of pH-Responsive Nanomaterials Based on the Tumor Microenvironment

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 705 - 721

Published: Jan. 1, 2025

The metabolic activity of tumor cells leads to the acidification surrounding microenvironment, which provides new strategies for application nanotechnology in cancer therapy.Researchers have developed various types pH-responsive nanomaterials based on acidic microenvironment.This review an in-depth discussion design mechanisms, drug-loading strategies, and pathways microenvironment-responsive nanodrug delivery systems.These materials trigger drug release upon reaching enhancing therapeutic targeting reducing toxicity healthy cells.pH-responsive include organic nanomaterials, inorganic composite nanomaterials.Additionally, this outlines prospects, challenges aiming promote development clinical translation field.

Language: Английский

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Tunable Ion-Release Biodegradable Nanoparticles Enhanced Pyroptosis for Tumor Immunotherapy

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123111 - 123111

Published: Jan. 15, 2025

Language: Английский

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PLGA confers upon conventional nonfluorescent molecules luminescent properties to trigger 1O2-induced pyroptosis and immune response in tumors

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 22, 2025

Language: Английский

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Biomaterials Elicit Pyroptosis Enhancing Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(7)

Published: Nov. 5, 2023

Abstract Cancer immunotherapy has the potential to revolutionize treatment of malignant tumors, but its effectiveness is limited by low immune response rate and immune‐related adverse events. Pyroptosis, as an inflammatory programmed cell death type, triggers strong acute antitumor immunity, converting “cold” tumors “hot”. Particularly, biomaterials loading pyroptosis inducers targeting tumor microenvironment engineer pyroptosis, have achieved great progress in recent years. Herein, design strategy, mechanism pathway, role induce cancer are comprehensively reviewed. The present review focuses on application biomaterials‐induced immunotherapy, including nanogel, polymer prodrug, nanovesicle, mesoporous material. Additionally, synthesis a series stimuli‐responsive nanoplatforms, glutathione‐responsive, pH‐responsive, reactive oxygen species‐responsive, enzyme‐mimicking catalytic performance, described. Meanwhile, it augments multiple processes uptake, antigen presentation, T‐cell activation, expansion. Finally, perspectives pyroptosis‐mediated inflammation break through vascular basement membrane barrier achieving efficient volcanic penetration discussed. Artificial intelligence, multi‐omics analysis, anthropogenic animal models organoids presented, aiming provide guidance assistance for constructing effective controllable pyroptosis‐engineered improving immunotherapy.

Language: Английский

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Dual Starvations Induce Pyroptosis for Orthotopic Pancreatic Cancer Therapy through Simultaneous Deprivation of Glucose and Glutamine

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(26), P. 17854 - 17865

Published: May 22, 2024

Pancreatic cancer is a highly fatal disease, and existing treatment methods are ineffective, so it urgent to develop new effective strategies. The high dependence of pancreatic cells on glucose glutamine suggests that disrupting this dependency could serve as an alternative strategy for therapy. We identified the vital genes transporter 1 (GLUT1) alanine-serine-cysteine 2 (ASCT2) through bioinformatics analysis, which regulate metabolism in cancer, respectively. Human serum albumin nanoparticles (HSA NPs) delivery GLUT1 ASCT2 inhibitors, BAY-876/V-9302@HSA NPs, were prepared by self-assembly process. This nanodrug inhibits uptake released BAY-876 V-9302, leading nutrition deprivation oxidative stress. inhibition leads synthesis glutathione, further aggravates Both them lead significant increase reactive oxygen species, activating caspase GSDMD finally inducing pyroptosis. study provides orthotopic dual starvation-induced screening metabolic targets using analysis followed constructing nanodrugs loaded with inhibitors will inspire future targeted therapy cancer.

Language: Английский

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Nanomaterials-Involved Tumor-Associated Macrophages’ Reprogramming for Antitumor Therapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(11), P. 7769 - 7795

Published: Feb. 29, 2024

Tumor-associated macrophages (TAMs) play pivotal roles in tumor development. As primary contents of environment (TME), TAMs secrete inflammation-related substances to regulate tumoral occurrence and There are two kinds TAMs: the tumoricidal M1-like protumoral M2-like TAMs. Reprogramming from immunosuppressive M2 immunocompetent M1 phenotype is considered a feasible way improve immunotherapeutic efficiency. Notably, nanomaterials show great potential for biomedical fields due their controllable structures properties. many types that exhibit regulatory activities TAMs' reprogramming. In this review, recent progress nanomaterials-involved reprogramming comprehensively discussed. The various strategies summarized introduced. Additionally, challenges perspectives efficient therapy discussed, aiming provide inspiration regulator design promote development TAMs-mediated immunotherapy.

Language: Английский

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A Novel Nanozyme to Enhance Radiotherapy Effects by Lactic Acid Scavenging, ROS Generation, and Hypoxia Mitigation

Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)

Published: May 5, 2024

Abstract Uveal melanoma (UM) is a leading intraocular malignancy with high 5‐year mortality rate, and radiotherapy the primary approach for UM treatment. However, elevated lactic acid, deficiency in ROS, hypoxic tumor microenvironment have severely reduced outcomes. Hence, this study devised novel CoMnFe‐layered double oxides (LDO) nanosheet multienzyme activities enhancement. On one hand, LDO nanozyme can catalyze hydrogen peroxide (H 2 O ) into oxygen reactive species (ROS), significantly boosting ROS production during radiotherapy. Simultaneously, efficiently scavenged thereby impeding DNA protein repair cells to synergistically enhance effect of Moreover, density functional theory (DFT) calculations decoded transformation pathway from pyruvic elucidating previously unexplored facet activity. The introduction innovative nanomaterial paves way novel, targeted, highly effective therapeutic approach, offering new avenues management other cancer types.

Language: Английский

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