ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(36), P. 42404 - 42412
Published: Aug. 29, 2023
Metal-organic
frameworks
(MOF)
are
promising
candidates
for
the
construction
of
artificial
nanozymes
and
have
found
applications
in
many
fields.
However,
preparation
nanosized
MOF
materials
with
high
performance
good
dispersibility
is
still
a
big
challenge
great
demand
as
signal
labels
immunoassays.
In
this
work,
hierarchically
structured
highly
dispersible
nanoparticles
were
facilely
prepared
one-pot
method.
Self-assembled
micelles
from
PEGylated
hematin
used
templates
to
mediate
formation
zeolitic
imidazole
framework-8
(ZIF-8)
aqueous
solution.
The
encapsulation
ZIF-8
produces
well-dispersed
generates
dual-confinement
effects
catalytic
hematin.
Owing
hierarchical
structures,
formed
show
enhanced
peroxidase-like
activity
enable
persistent
chemiluminescence
behaviors
luminol
system.
Sandwich-type
immunoassays
carcinoembryonic
antigen
(CEA)
proposed
using
labels,
analytical
performances
achieved.
combination
self-assembly
biomineralization
may
open
new
avenues
development
nanomaterials.
Nanoscale,
Journal Year:
2023,
Volume and Issue:
15(45), P. 18173 - 18183
Published: Jan. 1, 2023
This
mini-review
captures
the
emerging
direction
of
nanozymes
and
presents
a
comprehensive
overview
dual-atomic
site
nanozymes.
It
guides
exploration
next-generation
inspires
further
innovation
in
field.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
64(1)
Published: Aug. 22, 2024
Single-atom
nanozymes
(SAzymes)
with
ultrahigh
atom
utilization
efficiency
have
been
extensively
applied
in
reactive
oxygen
species
(ROS)-mediated
cancer
therapy.
However,
the
high
energy
barriers
of
reaction
intermediates
on
single-atom
sites
and
overexpressed
antioxidants
tumor
microenvironment
restrict
amplification
oxidative
stress,
resulting
unsatisfactory
therapeutic
efficacy.
Herein,
we
report
a
multi-enzyme
mimetic
MoCu
dual-atom
nanozyme
(MoCu
DAzyme)
various
catalytic
active
sites,
which
exhibits
peroxidase,
oxidase,
glutathione
(GSH)
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
oxidase
mimicking
activities.
Compared
Mo
SAzyme,
introduction
Cu
atoms,
formation
synergetic
effects
among
enhance
substrate
adsorption
reduce
barrier,
thereby
endowing
DAzyme
stronger
Benefiting
from
above
enzyme-like
activities,
can
not
only
generate
multiple
ROS,
but
also
deplete
GSH
block
its
regeneration
to
trigger
cascade
stress.
Additionally,
strong
optical
absorption
near-infrared
II
bio-window
endows
remarkable
photothermal
conversion
performance.
Consequently,
achieves
high-efficiency
synergistic
treatment
incorporating
collaborative
therapy
This
work
will
advance
applications
DAzymes
provide
valuable
insights
for
nanocatalytic
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(25), P. 7800 - 7808
Published: June 13, 2024
Metal
nanoclusters
feature
a
hierarchical
structure,
facilitating
their
ability
to
mimic
enzyme-catalyzed
reactions.
However,
the
lack
of
true
catalytic
centers,
compounded
by
tightly
bound
surface
ligands
hindering
electron
transfers
substrates,
underscores
need
for
universal
rational
design
methodologies
emulate
structure
and
mechanisms
natural
enzymes.
Motivated
transfer
in
active
centers
with
specific
chemical
structures,
integrating
peroxidase
cofactor
Fe-TCPP
onto
glutathione-stabilized
gold
(AuSG),
we
engineered
AuSG-Fe-TCPP
clusterzymes
remarkable
39.6-fold
enhancement
peroxidase-like
activity
compared
AuSG.
not
only
mimics
center
enhancing
affinity
H2O2,
but
also
facilitates
process,
enabling
efficient
H2O2
activation.
By
exemplifying
establishment
detecting
platform
trace
produced
ultrasonic
cleaners,
substantiate
that
bioinspired
surface-ligand-engineered
can
improve
sensing
performance
wider
linear
range
lower
detection
limit.
