International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113024 - 113024
Published: Aug. 31, 2024
Language: Английский
Exploration, Journal Year: 2024, Volume and Issue: 4(5)
Published: March 14, 2024
Abstract Neural interfaces, emerging at the intersection of neurotechnology and urban planning, promise to transform how we interact with our surroundings communicate. By recording decoding neural signals, these interfaces facilitate direct connections between brain external devices, enabling seamless information exchange shared experiences. Nevertheless, their development is challenged by complexities in materials science, electrochemistry, algorithmic design. Electrophysiological crosstalk mismatch electrode rigidity tissue flexibility further complicate signal fidelity biocompatibility. Recent closed‐loop brain‐computer while promising for mood regulation cognitive enhancement, are limited accuracy adaptability user interfaces. This perspective outlines challenges discusses progress contrasting non‐invasive invasive approaches, explores dynamics stimulation interfacing. Emphasis placed on applications beyond healthcare, highlighting need implantable high‐resolution capabilities.
Language: Английский
Citations
22
Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 177 - 177
Published: Jan. 31, 2024
Resveratrol is a natural phenolic compound with known benefits against neurodegeneration. We analyzed in vitro the protective mechanisms of resveratrol proinflammatory monomeric C-reactive protein (mCRP). mCRP increases risk AD after stroke and we previously demonstrated that intracerebral induces AD-like dementia mice. Here, used BV2 microglia treated for 24 h presence or absence resveratrol. Cells conditioned media were collected analysis. Lipopolysaccharide (LPS) has also been implicated progression so LPS was as resveratrol-sensitive reference agent. at concentration 50 µg/mL activated nitric oxide pathway NLRP3 inflammasome pathway. Furthermore, induced cyclooxygenase-2 release cytokines. effectively inhibited these changes increased expression antioxidant enzyme genes Cat Sod2. As central defense, hub Sirt1 Nfe2l2 nuclear translocation signal transducer NF-ĸB. Proinflammatory by primary mixed glial cultures protected This work provides mechanistic insight into preventing agents.
Language: Английский
Citations
20
Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155344 - 155344
Published: Jan. 8, 2024
Language: Английский
Citations
13
Nano Letters, Journal Year: 2024, Volume and Issue: 24(17), P. 5154 - 5164
Published: April 11, 2024
Developing novel strategies for defeating osteoporosis has become a world-wide challenge with the aging of population. In this work, supramolecular nanoagonists (NAs), constructed from alkaloids and phenolic acids, emerge as carrier-free nanotherapy efficacious treatment. These precision are formed through self-assembly berberine (BER) chlorogenic acid (CGA), utilizing noncovalent electrostatic, π–π, hydrophobic interactions. This assembly results in 100% drug loading capacity stable nanostructure. Furthermore, resulting weights proportions CGA BER within NAs meticulously controlled strong consistency when CGA/BER feed ratio is altered 1:1 to 1:4. As anticipated, our themselves could passively target osteoporotic bone tissues following prolonged blood circulation, modulate Wnt signaling, regulate osteogenic differentiation, ameliorate loss ovariectomy-induced mice. We hope work will open new strategy design efficient herbal-derived dealing intractable osteoporosis.
Language: Английский
Citations
10
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: July 18, 2024
Abstract Ischemic stroke is a complex, high-mortality disease with multifactorial etiology and pathogenesis. Currently, drug therapy mainly used treat ischemic in clinic, but there are still some limitations, such as limited blood-brain barrier (BBB) penetration efficiency, narrow treatment time window side effects. Recent studies have pointed out that delivery systems based on polymeric nanocarriers can effectively improve the insufficient for stroke. They provide neuronal protection by extending plasma half-life of drugs, enhancing drug’s permeability to penetrate BBB, targeting specific structures cells. In this review, we classified delivering drugs introduced their preparation methods. We also evaluated feasibility effectiveness discussed existing limitations prospects treatment. hoped review could theoretical basis future development nanomedicine Graphical
Language: Английский
Citations
9
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 3715 - 3735
Published: April 1, 2024
Liposomes, noted for their tunable particle size, surface customization, and varied drug delivery capacities, are increasingly acknowledged in therapeutic applications.These vesicles exhibit flexibility, enabling the incorporation of targeting moieties or peptides to achieve specific avoid lysosomal entrapment.Internally, adaptable architecture permits inclusion a broad spectrum drugs, contingent on solubility characteristics.This study thoroughly reviews liposome fabrication, modifications, release mechanisms post-systemic administration, with particular emphasis drugs crossing bloodbrain barrier (BBB) address lesions.Additionally, review delves into recent developments use liposomes ischemic stroke models, offering comparative evaluation other nanocarriers like exosomes nano-micelles, thereby facilitating clinical advancement.
Language: Английский
Citations
6
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4857 - 4875
Published: May 1, 2024
Abstract: Brain diseases are the most devastating problem among world's increasingly aging population, and number of patients with neurological is expected to increase in future. Although methods for delivering drugs brain have advanced significantly, none these approaches provide satisfactory results treatment diseases. This remains a challenge due unique anatomy physiology brain, including tight regulation limited access substances across blood-brain barrier. Nanoparticles considered an ideal drug delivery system hard-to-reach organs such as brain. The development new nanomaterial-based treatments has opened various opportunities scientists develop brain-specific systems that could improve outcomes disorders Alzheimer's disease, Parkinson's stroke tumors. In this review, we discuss noteworthy literature examines recent developments brain-targeted nanomedicines used Keywords: delivery, barrier, targeted nanoparticle, neurodegenerative diseases, stroke, cancer
Language: Английский
Citations
5
Biomedical Technology, Journal Year: 2024, Volume and Issue: 7, P. 32 - 45
Published: July 16, 2024
Ischemic stroke (IS), a major cause of death and disability globally, requires innovative therapeutic approaches due to its complex pathology. Nature medicine (NM) offers promising treatments through bioactive compounds, which target the multifaceted nature stroke-induced damage. However, clinical application NM is limited by challenges in bioavailability specificity. This review article presents an advanced perspective on integrating nanotechnology with create potent nanodelivery systems for ischemic treatment. We highlight pathological underpinnings stroke, including oxidative stress, inflammation, apoptosis, discuss how compounds offer targeted mitigation strategies. By incorporating platforms, such as liposomes nanoparticles, these -based can achieve enhanced targeting, solubility, controlled release, significantly improving outcomes while reducing side effects. Despite developments, translation nano-enhanced into practice faces obstacles, manufacturing scalability, regulatory approval, safety evaluations. emphasizes potential combining advance therapy, calling integrated research efforts overcome existing barriers fully realize benefits this approach.
Language: Английский
Citations
5
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117564 - 117564
Published: Oct. 13, 2024
Language: Английский
Citations
5
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(50)
Published: Nov. 6, 2024
Abstract Oxidative stress, predominantly from neuronal mitochondrial damage and the resultant cytokine storm, is central to cerebral ischemia‐reperfusion injury (CIRI). However, delivering drugs mitochondria remains challenging due blood‐brain barrier (BBB), which impedes drug entry into affected brain tissues. This study introduces an innovative tannic acid (TA) melanin‐modified heteropolyacid nanomedicine (MHT), highly specifically eliminates reactive oxygen radicals burst efficiently reduce through a strategically designed sequential targeting strategy tissue mitochondria. TA endows MHT with ability by binding matrix proteins exposed damaged BBB outer membrane of neurons, while melanin significantly enhances antioxidant capacity MHT. Consequently, effectively inhibits apoptosis protecting reversing inflammatory immune environment deactivation cyclic GMP‐AMP synthase–stimulator interferon genes (cGAS‐STING) pathway. demonstrated strong therapeutic effect on CIRI, ultralow dose (2 mg kg −1 ) proving effective in condition. work not only new avenue CIRI therapy but also offers paradigm for treating other diseases.
Language: Английский
Citations
5