Implantable Microneedles Loaded with Nanoparticles Surface Engineered Escherichia coli for Efficient Eradication of Triple-Negative Breast Cancer Stem Cells

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Eliminating cancer stem cells (CSCs) is essential for the effective treatment of triple-negative breast (TNBC). This study synthesized Au@cerium-zinc composite core@shell nanoparticles (Au@Zn/CeO) that were subsequently conjugated with Escherichia coli (E. coli) to create engineered bacterium AZCE, which was then combined microneedle carriers and freeze-dried obtain AZCE-MN. Upon implantation into TNBC tumors, inherent properties E. facilitate AZCE penetrate extracellular matrix break through basement membrane, enabling delivery AZC CSCs-enriched regions deep within tumor. The released Zn2+ induces mitochondrial dysfunction amplifies reactive oxygen species (ROS) production. redox cycling between Ce3+/Ce4+ effectively depleted glutathione, further increased ROS generation. Under near-infrared laser irradiation, Au nanorods initiated photothermal therapy, ablating CSCs while amplifying catalytic reactions ionic effects. microneedle-mediated bacteria improved nanodrug penetration in tumor tissues, providing new insights clinical treatment.

Language: Английский

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Double‐Edged Dissolving Microneedle Patches Loaded with Zn/Ce Composites and Vancomycin for Treatment of Drug‐Resistant Bacterial Infected Skin Abscess

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

The management of abscess wounds induced by antibiotic-resistant bacterial infections has become increasingly formidable due to the widespread overutilization and misuse antimicrobial agents. This study presents an innovative dissolvable microneedle (MN) patch incorporating Au@ZnO/Ce nanocomposites vancomycin (AZC/Van@MN), exhibiting robust anti-inflammatory properties, meticulously engineered for therapeutic intervention wounds. developed AZC/Van@MN demonstrates exceptional biocompatibility as evidenced comprehensive histopathological hematological assessments. It effectively eradicates colonies through synergistic action Van mild photothermal therapy (PTT, ≤42 °C). Transcriptomic analysis elucidates that antibacterial mechanism involves upregulation riboflavin biosynthesis suppression arginine pathways. Furthermore, significantly reduces dimensions, load, inflammatory response, while simultaneously enhancing wound healing via accelerated re-epithelialization angiogenesis. double-edged MN represents a promising strategy combating skin abscesses instigated bacteria.

Language: Английский

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Brain gliomas: Diagnostic and therapeutic issues and the prospects of drug-targeted nano-delivery technology

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107308 - 107308

Published: July 15, 2024

Glioma is the most common intracranial malignant tumor, with severe difficulty in treatment and a low patient survival rate. Due to heterogeneity invasiveness of tumors, lack personalized clinical design, physiological barriers, it often difficult accurately distinguish gliomas, which dramatically affects subsequent diagnosis, imaging treatment, prognosis. Fortunately, nano-delivery systems have demonstrated unprecedented capabilities diagnosing treating gliomas recent years. They been modified surface efficiently traverse BBB/BBTB, target lesion sites, intelligently release therapeutic or contrast agents, thereby achieving precise treatment. In this review, we focus on systems. Firstly, provide an overview standard emerging diagnostic technologies for glioma practice. After induction analysis, summarizing delivery methods drug systems, design nanoparticles, their new advances Finally, discussed prospects potential challenges drug-delivery glioma.

Language: Английский

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Au Nanorods Activate Zn²⁺/Ag⁺ Mediated Anti-inflammatory for Enhanced Methicillin-Resistant Wound Repair via Bionic Claw Microneedles

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(10), P. 4791 - 4800

Published: Sept. 24, 2024

Language: Английский

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In-situ growth of CeO2 on biofilms: Innovative nanoparticles for photothermal therapy & multi-pronged attack on Alzheimer’s disease

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 238, P. 113887 - 113887

Published: April 1, 2024

Language: Английский

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Sono-blasting Triggered Cascading-Amplification of Oxidative Stress for Enhanced Interventional Therapy of Hepatocellular Carcinoma

Nano Letters, Journal Year: 2024, Volume and Issue: 24(29), P. 8996 - 9003

Published: July 12, 2024

Interventional therapy is widely regarded as a highly promising treatment approach for nonsurgical liver cancer. However, the development of drug resistance and tolerance to hypoxic environments after embolization can lead increased angiogenesis, enhanced tumor cell stemness, greater invasiveness, resulting in metastasis recurrence. To address these challenges, novel involving use lecithin DSPE-PEG comodified Ca

Language: Английский

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NIR‐II‐Responsive Hybrid System Achieves Cascade‐Augmented Antitumor Immunity via Genetic Engineering of Both Bacteria and Tumor Cells

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

Abstract The combination of nanoparticles and tumor‐targeting bacteria for cancer immunotherapy can overcome the shortcomings poor nanoparticle accumulation, limited penetration, restricted distribution. However, it remains a great challenge hybrid system to improve therapeutic efficacy through simultaneous controllable regulation immune cells tumor cells. Herein, platform is rationally designed achieve cascade‐augmented immunotherapy. To construct hybrids, photothermal responsive light in second near‐infrared (NIR‐II) region are conjugated onto surface engineered pH‐responsive Schiff base bonds. Taking advantage hypoxia targeting deep penetration characteristics bacteria, hybrids accumulate at sites. Then detach from realize genetic engineering cells, which induces cell apoptosis down‐regulate expression programmed death ligand 1 alleviate immunosuppressive microenvironment. mild heating not only induce tumor‐associated antigen release, but also trigger sustainable cytokine interleukin‐2. Notably, synergistic antitumor effect achieved between process p53 transfection NIR‐II light‐activated bacteria. This work proposes facile strategy construction

Language: Английский

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Degradable Microneedle Patch with Photothermal-Promoted Bacteria-Infected Wound Healing and Microenvironment Remodeling

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(25), P. 32017 - 32026

Published: June 14, 2024

Bacteria-infected wound healing is one of the most challenging issues in health management that attracting worldwide concerns. Despite great achievements with antibiotics, emergence antibiotic-resistance retarded process and also led to severe outcomes. Exploration novel antibiotics together amelioration efficacy desirable. Herein, a degradable microneedle patch (AAZH@MNs) was fabricated through incorporating near-infrared light responsive photothermal agents for sustained bacteria killing prevention biofilm formation. In addition, antibacterial could even remold microenvironment bacteria-infected wounds an effect, significantly facilitating process.

Language: Английский

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Ce Single Atom with Cascaded Self‐Circulating Enzyme‐Like Activities and Photothermal Activities for Cancer Therapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract Specific regulation of the tumor microenvironment (TME) is a potential strategy for therapy. Although many TME‐responsive nanozymes have been developed therapy, limited substrates affect therapeutic effect. In this study, cerium single‐atom (Ce SAs) are prepared by immobilizing (Ce) using zeolitic imidazolate framework‐8 (ZIF‐8) as precursor. The reversible conversion between Ce 3+ and 4+ endows SAs with multiple enzyme‐like activities, such peroxidase (POD)‐like activity, oxidase (OD)‐like catalase (CAT)‐like glucose (GOD)‐like glutathione (GSH‐Px)‐like activity. All above enzyme activities give cascade self‐circulation properties can be used therapy in TME. addition, also photothermal properties, which achieve (PTT) cells under 808 nm near‐infrared (NIR) irradiation. Combining self‐cycling SAs, synergistic makes attractive efficacy treatment.

Language: Английский

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Fe₃O₄@Bi₂S₃ Nanoparticles Mediated MRI-Guided Precision Radiosensitization for Orthotopic Glioblastoma via External Magnetism

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Radioresistance in tumors and the excess damage normal tissues during radiotherapy (RT) restrict clinical application of glioblastoma RT. Image-guided radiosensitization is hopefully adopted to achieve precision Nevertheless, therapeutic effect radiosensitizers unsatisfactory due limitations blood–brain barrier poor tumor targeting. Herein, Fe3O4@Bi2S3 nanoparticles coated with a cell membrane (denoted as FBM) have been designed sensitize FBM accumulates precisely within via external magnetism homologous adhesion capability. Afterward, releases high-Z atoms (Bismuth) ionizing radiation micro acidic environments that interact generate high densities secondary radiation, which leads enhanced dose deposits. Simultaneously, generates reactive oxygen species, lipid peroxidation Fe2+, depletes glutathione, downregulates glutathione peroxidase 4 activate ferroptosis. Notably, growth inhibition rate FBM-mediated RT increases 75.49% orthotopic model. Besides, magnetic resonance imaging performance shows potential diagnosis therapy surveillance, thereby reducing adjacent realizing MRI-guided Hence, novel multifunctional nanoplatform offers for image-guided induced by activating ferroptosis, thus presenting an efficient radiotherapeutic approach glioblastoma.

Language: Английский

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