Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106410 - 106410
Published: Nov. 1, 2024
Language: Английский
Matter, Journal Year: 2025, Volume and Issue: 8(3), P. 101942 - 101942
Published: Jan. 13, 2025
Language: Английский
Citations
2
Research, Journal Year: 2024, Volume and Issue: 7
Published: Jan. 1, 2024
Micro/nanorobots (MNRs) are envisioned to provide revolutionary changes therapies for infectious diseases as they can deliver various antibacterial agents or energies many hard-to-reach infection sites. However, existing MNRs face substantial challenges in addressing complex infections that progress from superficial deep tissues. Here, we develop swarming magnetic Fe 3 O 4 @polydopamine-tannic acid nanorobots (Fe @PDA-TA NRs) capable of performing targeted bacteria elimination complicated bacterial by integrating photothermal and chemical strategies. The nanoparticles (NPs), serving building blocks the nanorobots, fabricated situ polymerization dopamine followed TA adhesion. When driven alternating fields, NPs assemble into large energetic microswarms continuously flowing forward with tunable velocity. Thus, NRs be navigated achieve rapid broad coverage a area distance rapidly eradicate residing there upon exposure near-infrared (NIR) light due their efficient conversion. Additionally, concentrate at sites traversing through confined, narrow, tortuous passages, exerting sustained action surface TA-induced easy cell adhesion subsequent membrane destruction. Therefore, show great potential superficial-to-deep infections. This study may inspire development future therapeutic microsystems multifunction synergies, task flexibility, high efficiency.
Language: Английский
Citations
10
Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
Abstract The unique optical properties of structural colors found in nature garner significant attention. Inspired by these natural phenomena, scientists develop a variety stimuli‐responsive hydrogel photonic materials with periodic structures that can adjust their response to environmental changes. In recent years, the emergence continue grow, showcasing potential various advanced applications. This article reviews latest advancements materials, focusing on classification, manufacturing methods, and practical It provides detailed descriptions across different dimensions highlights derived from microstructures. Additionally, outlines innovative technologies are employed creating diverse structures. These demonstrate sensitivity range external stimuli, including temperature, humidity, pH, light exposure, mechanical force, allowing for dynamic adjustments both structure performance. Furthermore, discusses typical applications areas such as visual sensing, anti‐counterfeiting technology, drug delivery. Last, it examines current challenges faced field offers forward‐looking insights regarding future application materials.
Language: Английский
Citations
0
Nano Biomedicine and Engineering, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
2
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(36), P. 47163 - 47177
Published: Aug. 28, 2024
Central nervous system (CNS) infections caused by neurosurgery or intrathecal injection of contaminated cerebrospinal fluid are a common and difficult complication. Drug-delivery microrobots among the latest solutions proposed for antibacterial applications. However, there is lack research into developing with ability to sustain antibody delivery while can move efficiently in CNS. Here, biocompatible metal–organic framework (MOF)-modified microrollers (MMRs) combat CNS proposed. The MMRs iron-based (NH2-MIL-101(Fe)) modified enhanced adsorption Fe/Al coated magnetic actuation biocompatibility. have demonstrated faster unhindered magnetically actuated motion on uneven biological tissue surface an organ-on-a-chip that mimicked compared it smooth surface. CFD results consistently align experimental findings. be loaded rhodamine 6G bioimaging, allowing them imaged through sections main human tissues fluorescence microscopy, tetracycline hydrochloride antibiotic delivery, inhibit growth Staphylococcus aureus biofilms sustained release antibiotics 9 days. This study provides strategy integrate high-capacity material locomotion long-term targeted applications environments.
Language: Английский
Citations
1
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(41), P. 10550 - 10558
Published: Jan. 1, 2024
Micro/nanorobots (MNRs) hold great promise for various applications due to their capability execute complex tasks in hard-to-reach micro/nano cavities. However, the developed magnetic MNRs, as marionettes of external fields, lack built-in intelligence self-targeting, while chemotactic MNRs suffer from limited self-targeting range. Here, we demonstrate magnetic-chemotactic ZnO/Fe-Ag Janus microrobots (JMRs) capable rapid, remote bacterial elimination. The JMRs utilize Fe engine coarse navigation a distance, allowing control swiftly guide them vicinity hidden/uncharted target that establishes local chemical gradient ([CO
Language: Английский
Citations
1
Energy, Journal Year: 2024, Volume and Issue: 313, P. 133792 - 133792
Published: Nov. 12, 2024
Language: Английский
Citations
1
Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12
Published: Nov. 8, 2024
The application of micro/nanomotors (MNMs) in the gastrointestinal tract has become a Frontier treatment diseases. These miniature robots can enter through oral administration, achieving precise drug delivery and therapy. They traverse mucosal layers tissue barriers, directly targeting tumors or other lesion sites, thereby enhancing bioavailability therapeutic effects drugs. Through nanotechnology, these MNMs are able to accomplish targeted medication release, regulating release response either external stimuli local biological milieu. This results reduced side increased efficacy. review summarizes primary classifications power sources current MNMs, as well their applications tract, providing inspiration direction for diseases with MNMs.
Language: Английский
Citations
0
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: Nov. 13, 2024
Introduction Osteosarcoma, characterized by high mortality and disability rates, poses a significant challenge due to its complex genetic background the absence of specific membrane receptors, which hinder effective targeted therapy. Active targeting has emerged as promising approach address this issue. Methods In study, magnetically driven hydrogel robots (MMHR) were utilized load deliver drugs precisely target sites. The included SCR1481B16, MET inhibitor proven inhibit MET-driven tumor growth, Anlotinib. microrobots designed navigate under magnetic guidance, enhancing drug efficacy while minimizing damage normal tissues. Results study explored potential MMHR loaded with SCR1481B16 Anlotinib in treatment Anlotinib-resistant osteosarcoma. successfully produced, demonstrating ability Evaluation showed an enhanced sensitivity tumors Anlotinib, providing new insights into drug-resistant Discussion Tumors overexpressing often develop resistance VEGFR-targeted drugs. use combination delivered microrobots, offers novel strategy overcome resistance. However, further in-depth research validation are required before clinical application method can be considered. Conclusion conclusion, provide for osteosarcoma, bringing hope future applications challenging disease.
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106410 - 106410
Published: Nov. 1, 2024
Language: Английский
Citations
0