Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(42), P. 10818 - 10834
Published: Jan. 1, 2024
Prodrugs, activated at the tumor site, offer targeted treatment but may still cause unintended cytotoxicity. This review explores combination of bioorthogonal reactions with prodrug strategies to improve safety and efficacy.
Language: Английский
Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)
Published: Feb. 24, 2025
Abstract Sonodynamic therapy (SDT) as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound (US), which can safely penetrate the tissue without significant attenuation. SDT not only has advantages including high precision, non-invasiveness, minimal side effects, but also overcomes limitation of low penetration light to deep tumors. The cytotoxic reactive oxygen species be produced by utilization combined with US kill tumor cells. However, underlying mechanism been elucidated, its unsatisfactory efficiency retards further clinical application. Herein, we shed on main mechanisms types sonosensitizers, organic inorganic sonosensitizers. Due development nanotechnology, many novel nanoplatforms are utilized this arisen field solve barriers enable continuous innovation. This review highlights potential nanosonosensitizers focus enhanced based monotherapy or synergistic that difficult reach traditional treatment, especially orthotopic cancers.
Language: Английский
Citations
4
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Abstract Precise control over drug release rates is critical for enhancing therapeutic efficacy, reducing side effects, and maintaining stable levels. While microneedles (MNs) offer a promising approach transdermal delivery, conventional passive‐response systems often lack adaptability across diverse drugs disease models, limiting their versatility. Here, this work presents flexible bioelectronic microneedle patch (FBMP) that integrates electronics actively controlled delivery. The FBMP incorporates printed circuit board (FPCB), eutectic gallium‐indium (EGaIn) heating film, dual‐layer with polyvinyl alcohol (PVA) core polycaprolactone (PCL) shell. This configuration allows real‐time adjustment of the thermal response rate via smartphone‐controlled Bluetooth, achieving rapid within 2 min or sustained 10 h. In various animal demonstrate versatility in delivering multiple types, optimizing minimizing effects both acute chronic conditions. Overall, introduces flexible, universal electronic platform significant potential to advance precision personalized medicine by enabling customizable, release.
Language: Английский
Citations
1
Seminars in Oncology, Journal Year: 2025, Volume and Issue: 52(2), P. 152339 - 152339
Published: April 1, 2025
Language: Английский
Citations
1
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 7, 2024
Extracellular and transmembrane proteins, which account for the products of approximately 40% all protein-encoding genes in tumors, play a crucial role shaping tumor immunosuppressive microenvironment (TIME). While protein degradation therapy has been applied to membrane proteins cancer cells, it rarely extended immune cells. We herein report polymeric nanolysosome targeting chimera (nano-LYTAC) that undergoes on M2 macrophages generates sonodynamic effect combinational immunotherapy. Nano-LYTAC is found have higher efficacy interleukin 4 receptor (IL-4R) compared traditional inhibitors. More importantly, revealed nano-LYTAC function macrophage concentration-dependent: downregulating CD206 expression 10 (IL-10) secretion from at low concentration, while triggering their apoptosis high concentration. Moreover, possess long retention (>48 h), allowing multiple treatments with single dose. Such synergistic immunotherapy mediated by effectively reprograms TIME via inhibiting functions regulatory T cells (Tregs), as well promoting maturation dendritic (DCs) infiltration effector (Teffs), completely suppressing growth, pulmonary metastasis, preventing recurrence under preclinical animal models.
Language: Английский
Citations
8
Small, Journal Year: 2024, Volume and Issue: 20(47)
Published: Aug. 27, 2024
Gene therapy and sonodynamic therapy, as emerging treatment methods, have great potential in cancer treatment. However, there are significant challenges the vivo delivery of genes sonosensitizers during process, which ultimately affects therapeutic outcome. In this study, an ultrasound-sensitive targeted liposome nanoparticle system (MLip
Language: Английский
Citations
5
Aggregate, Journal Year: 2025, Volume and Issue: unknown
Published: April 11, 2025
ABSTRACT Sonodynamic therapy (SDT) is an innovative cancer modality that harnesses the energy of ultrasound to activate sonosensitizers for producing reactive oxygen species (ROS), culminating in eradication tumor cells. Compared with photodynamic therapy, SDT has capacity penetrate deeply into biological tissues, thereby holding significant promise addressing situated or surgically inaccessible tumors. The effectiveness greatly dependent on characteristics sonosensitizers, and unlike inorganic organic offer a more controlled synthesis process have excellent biocompatibility. This review presents meticulous undertaking categorize elucidate their mechanisms action therapeutic effects context SDT. Design strategies are also summarized, we emphasize critical role nanotechnology localization, imaging, multimodal synergistic offering approach achieving precise targeting. In addition, impact delineated when integrated other oncological modalities, such as photothermal enhance efficacy. Finally, discusses challenges future perspectives advancement clinical within realm oncology.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113719 - 113719
Published: April 1, 2025
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: May 9, 2025
Abstract Glioblastoma (GBM) remains one of the deadliest forms cancer due to its high rates postoperative recurrence and resistance treatment. Temozolomide (TMZ) is standard chemotherapy for GBM. However, therapeutic efficacy TMZ significantly compromised by activation various intracellular DNA repair mechanisms that facilitate resistance. Herein, upregulation bromodomain‐containing protein 4 (BRD4) expression demonstrated be a key contributor in To address this challenge, biomimetic hybrid PROteolysis TArgeting Chimeras (PROTAC) liposome delivery system (M@TP) developed. This efficiently penetrates blood‐brain barrier (BBB) specifically targets GBM cells through homotypic recognition. Once within TMZ‐resistant cells, released PROTAC from M@TP can degrade BRD4, effectively inhibiting multiple pathways restoring sensitivity In vivo, studies showed significant suppressing tumor growth both GBM, with prolonged mouse survival times. These findings highlight potential as promising strategy overcome improve outcomes
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: May 13, 2025
Abstract Cuproptosis, as a novel mechanism of cell death, holds significant promise for tumor therapy. However, existing studies typically employ methods to induce cuproptosis through endogenous or exogenous pathways, which often fail achieve precise control in both space and time. Herein, polymeric nanoparticles (RC NPs) are developed that enable activation acoustic tumor‐specific treatment. The fabricated via self‐assembly degradable, acoustic‐sensitive polymer (Poly RA) metal‐ion‐loadable polyphenol‐structured MPN). Ultrasound stimulation cleaved the RC NPs, generating reactive oxygen species (ROS) promoting release copper ions from Poly MPN, leading aggregation lipoylated proteins depletion iron‐sulfur cluster introduce cuproptosis. Subsequently, NPs successfully activated immune system mice, maturation antigen‐presenting cells T lymphocytes. exhibited good biosafety inhibition orthotopic patient‐derived xenograft (PDX) models. These provide promising modality treatment highly aggressive cancers valuable avenue future clinical applications.
Language: Английский
Citations
0
ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown
Published: May 15, 2025
Language: Английский
Citations
0