Engineering precision nanoparticles for drug delivery

Nature Reviews Drug Discovery, Journal Year: 2020, Volume and Issue: 20(2), P. 101 - 124

Published: Dec. 4, 2020

Language: Английский

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mRNA vaccines — a new era in vaccinology

Nature Reviews Drug Discovery, Journal Year: 2018, Volume and Issue: 17(4), P. 261 - 279

Published: Jan. 12, 2018

Language: Английский

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Lipid nanoparticles for mRNA delivery

Nature Reviews Materials, Journal Year: 2021, Volume and Issue: 6(12), P. 1078 - 1094

Published: Aug. 10, 2021

Language: Английский

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Delivery technologies for cancer immunotherapy

Nature Reviews Drug Discovery, Journal Year: 2019, Volume and Issue: 18(3), P. 175 - 196

Published: Jan. 8, 2019

Language: Английский

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Reactive Oxygen Species (ROS)-Based Nanomedicine

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(8), P. 4881 - 4985

Published: April 11, 2019

Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms. The intrinsic biochemical properties ROS, which underlie the mechanisms necessary for growth, fitness, or aging organisms, have been driving researchers to take full advantage these active chemical contributing medical advances. Thanks remarkable advances nanotechnology, great varieties nanomaterials with unique ROS-regulating explored guide temporospatial dynamic behaviors ROS biological milieu, contributes emergence a new-generation therapeutic methodology, i.e., nanomaterial-guided vivo evolution therapy. interdependent relationship between and their corresponding chemistry, biology, nanotherapy leads us propose concept "ROS science", is believed be emerging scientific discipline that studies mechanisms, effects, nanotherapeutic applications ROS. In this review, state-of-art concerning recent progresses on ROS-based nanotherapies summarized detail, emphasis underlying material chemistry by are generated scavenged improved outcomes. Furthermore, key issues cross-disciplinary fields also discussed, aiming unlock innate powers optimized efficacies. We expect our demonstration evolving field will beneficial further development fundamental researches clinical applications.

Language: Английский

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Nanotechnology for Multimodal Synergistic Cancer Therapy

Chemical Reviews, Journal Year: 2017, Volume and Issue: 117(22), P. 13566 - 13638

Published: Oct. 19, 2017

The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic potential treatment. Therefore, current trend in clinical research has gradually shifted from a focus on monotherapy to combination therapy for enhanced treatment efficacy. More importantly, cooperative enhancement interactions between several types contribute naissance multimodal synergistic therapy, which results remarkable superadditive (namely "1 + 1 > 2") effects, stronger than any single or their theoretical combination. In this review, state-of-the-art studies concerning recent advances nanotechnology-mediated will be systematically discussed, with an emphasis construction multifunctional nanomaterials realizing bimodal trimodal as well intensive exploration underlying mechanisms explaining significant improvements outcome. Furthermore, featured applications overcoming tumor multidrug resistance, hypoxia, metastasis also discussed detail, may provide new ways efficient regression even elimination drug resistant, hypoxic solid, distant metastatic tumors. Finally, some design tips outlook future development provided, highlighting key scientific issues technical challenges requiring remediation accelerate translation.

Language: Английский

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Smart cancer nanomedicine

Nature Nanotechnology, Journal Year: 2019, Volume and Issue: 14(11), P. 1007 - 1017

Published: Nov. 1, 2019

Language: Английский

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mRNA vaccines for infectious diseases: principles, delivery and clinical translation

Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 20(11), P. 817 - 838

Published: Aug. 25, 2021

Language: Английский

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Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

Molecular Therapy, Journal Year: 2019, Volume and Issue: 27(4), P. 710 - 728

Published: Feb. 19, 2019

mRNA has broad potential as a therapeutic. Current clinical efforts are focused on vaccination, protein replacement therapies, and treatment of genetic diseases. The translation therapeutics been made possible through advances in the design manufacturing intracellular delivery methods. However, application is still limited by need for improved systems. In this review, we discuss challenges mRNA-based therapeutics, with an emphasis recent biomaterials strategies, present overview applications therapy, gene editing, vaccination.

Language: Английский

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Advances in Biomaterials for Drug Delivery

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(29)

Published: May 7, 2018

Abstract Advances in biomaterials for drug delivery are enabling significant progress biology and medicine. Multidisciplinary collaborations between physical scientists, engineers, biologists, clinicians generate innovative strategies materials to treat a range of diseases. Specifically, recent advances include major breakthroughs cancer immunotherapy, autoimmune diseases, genome editing. Here, the design implementation reviewed. A brief history field is first established, then commentary on RNA delivery, responsive development, immunomodulation provided. Current challenges associated with these areas as well opportunities address long‐standing problems medicine discussed throughout.

Language: Английский

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