Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(1), P. 38 - 71

Published: Nov. 2, 2018

Recent progress in developing organic semiconducting materials (OSMs) for deep-tissue optical imaging, cancer phototherapy and biological photoactivation is summarized.

Language: Английский

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Second near-infrared photothermal materials for combinational nanotheranostics

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 50(2), P. 1111 - 1137

Published: Nov. 27, 2020

This review summarizes the recent development of second near-infrared photothermal combinational nanotheranostics for cancer, infectious diseases and regenerative medicine.

Language: Английский

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Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(49)

Published: July 29, 2018

Optical imaging has played a pivotal role in biology and medicine, but it faces challenges of relatively low tissue penetration poor signal-to-background ratio due to light scattering autofluorescence. To overcome these issues, second near-infrared fluorescence, self-luminescence, photoacoustic have recently emerged, which utilize an optical region with reduced light-tissue interactions, eliminate real-time excitation, detect acoustic signals negligible attenuation, respectively. Because there are only few endogenous molecules absorbing or emitting above the visible region, development contrast agents is essential for those deep-tissue modalities. Organic semiconducting π-conjugated frameworks can be synthesized meet different requirements their easy chemical modification legible structure-property relation. Herein, applications organic including small-molecule nanoparticle derivatives summarized. In particular, molecular engineering nanoformulation approaches further improve detection sensitivity modalities highlighted. Finally, current potential opportunities this emerging subfield biomedical discussed.

Language: Английский

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Recent Advances in Cell Membrane–Camouflaged Nanoparticles for Cancer Phototherapy

Small, Journal Year: 2018, Volume and Issue: 15(1)

Published: Nov. 20, 2018

Abstract Phototherapy including photothermal therapy (PTT) and photodynamic (PDT) employs phototherapeutic agents to generate heat or cytotoxic reactive oxygen species (ROS), has therefore garnered particular interest for cancer therapy. However, the main challenges faced by conventional include easy recognition immune system, rapid clearance from blood circulation, low accumulation in target sites. Cell‐membrane coating emerged as a potential way overcome these limitations, owing abundant proteins on surface of cell membranes that can be inherited membrane–camouflaged nanoparticles. This review summarizes recent advances development biomimetic nanoparticles phototherapy. Different sources used coat uisng different approaches. After cell‐membrane coating, photophysical properties original remain nearly unchanged; however, coated are equipped with additional physiological features escape, vivo prolonged circulation time, homologous targeting, depending sources. Moreover, membrane ablated under laser irradiation, leading drug release thus synergetic By combining other supplementary normalize tumor microenvironment, further enhance therapeutic efficacy against cancer.

Language: Английский

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Semiconducting Polymer Nanomaterials as Near-Infrared Photoactivatable Protherapeutics for Cancer

Accounts of Chemical Research, Journal Year: 2020, Volume and Issue: 53(4), P. 752 - 762

Published: Feb. 6, 2020

Cancer therapy is routinely performed in the clinic to cure cancer and control its progression, wherein therapeutic agents are generally used. To reduce side effects, protherapeutic that can be activated by overexpressed biomarkers under development. However, these still face certain extent of off-target activation normal tissues, stimulating interest design external-stimuli activatable protherapeutics. In this regard, photoactivatable have been utilized for treatments. because intrinsic features photolabile moieties, most only respond ultraviolet-visible light, limiting their vivo applications. Thus, near-infrared (NIR) light with minimal phototoxicity increased tissue penetration highly desired.In Account, we summarize our semiconducting polymer nanomaterials (SPNs) as NIR treatment. SPNs transformed from π-conjugated polymers efficiently convert into heat or singlet oxygen (1O2). With photothermal photodynamic properties, directly used photomedicine serve transducers activate 1O2-responsive agents.The heat-activatable SPN-based developed loading conjugating (e.g., agonist, gene, enzyme). For instance, photothermally triggered release agonists specifically activates protein ion channels on cellular membrane, leading overinflux induced mitochondria dysfunction consequently apoptosis cells. Moreover, temperature-sensitive bromelain promote situ degradation collagens (the major components extracellular matrix), resulting an improved accumulation tumor tissues thus amplified outcome.The 1O2-activatable constructed through covalent conjugation caged via hypoxia- 1O2-cleavable linkers. Upon photoirradiation, consume generate 1O2, which leads (PDT), meanwhile breaks linkers on-demand molecules chemodrug, enzyme, inhibitor). Such remote applied induce DNA damage, ribonucleic acid degradation, inhibition biosynthesis, immune system tumors living animals. By synergizing PDT photoactivation those biological actions, effectively eliminate even fully inhibit metastasis.This Account highlights potential construction versatile protherapeutics treat at designated times locations high outcome precision.

Language: Английский

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In vivo theranostics with near-infrared-emitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration

Light Science & Applications, Journal Year: 2018, Volume and Issue: 7(1)

Published: Nov. 21, 2018

Carbon dots that exhibit near-infrared fluorescence (NIR CDs) are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability targeting compared to currently used photoluminescence agents. Despite progress in the synthesis of NIR CDs, there remains a key obstacle using them as an vivo theranostic agent. This work demonstrates newly developed sulfur nitrogen codoped CDs highly efficient photothermal therapy (PTT) mouse models (conversion efficiency 59%) can be readily visualized by photoacoustic imaging. The real potential is enhanced their unique biodistribution targeting. Contrary all other have been tested biomedicine, they excreted through body's renal filtration system. Moreover, after intravenous injection, accumulated tumor tissue via passive targeting, without any active species such antibodies. Due accumulation need intratumor high conversion, excellent optical imaging performance, excretion, suitable transfer clinical practice.

Language: Английский

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Platelet Membrane‐Camouflaged Magnetic Nanoparticles for Ferroptosis‐Enhanced Cancer Immunotherapy

Small, Journal Year: 2020, Volume and Issue: 16(22)

Published: April 27, 2020

Abstract Although cancer immunotherapy has emerged as a tremendously promising therapy method, it remains effective only for several cancers. Photoimmunotherapy (e.g., photodynamic/photothermal therapy) could synergistically enhance the immune response of immunotherapy. However, excessively generated immunogenicity will cause serious inflammatory syndrome. Herein, biomimetic magnetic nanoparticles, Fe 3 O 4 ‐SAS @ PLT, are reported novel approach to sensitize ferroptosis and generate mild immunogenicity, enhancing rate non‐inflamed tumors ‐SAS@PLT built from sulfasalazine (SAS)‐loaded mesoporous nanoparticles (Fe ) platelet (PLT) membrane camouflage triggered ferroptotic cell death via inhibiting glutamate‐cystine antiporter system X c − pathway. PLT‐mediated significantly improves efficacy programmed 1 checkpoint blockade achieves continuous tumor elimination in mouse model 4T1 metastatic tumors. Proteomics studies reveal that not induce tumor‐specific but also efficiently repolarize macrophages immunosuppressive M2 phenotype antitumor M1 phenotype. Therefore, concomitant with expected provide great potential clinical treatment metastasis.

Language: Английский

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Macrotheranostic Probe with Disease‐Activated Near‐Infrared Fluorescence, Photoacoustic, and Photothermal Signals for Imaging‐Guided Therapy

Angewandte Chemie International Edition, Journal Year: 2018, Volume and Issue: 57(26), P. 7804 - 7808

Published: April 17, 2018

Abstract Theranostics provides opportunities for precision cancer therapy. However, theranostic probes that simultaneously turn on their diagnostic signal and pharmacological action only in respond to a targeted biomarker have been less exploited. We herein report the synthesis of macrotheranostic probe specifically activates its near‐infrared fluorescence (NIRF), photoacoustic (PA), photothermal signals presence cancer‐overexpressed enzyme imaging‐guided Superior small‐molecule counterpart probe, has ideal biodistribution renal clearance, permitting passive targeting tumors, situ activation multimodal signals, effective ablation. Our study thus macromolecular approach towards activatable phototheranostics.

Language: Английский

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Recent Progresses in Phototherapy‐Synergized Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2018, Volume and Issue: 28(46)

Published: Sept. 20, 2018

Abstract Cancer immunotherapy has recently gained much attention in the search of cancer cure due to its ability “train” immune system seeking out and removing residual tumor cells. However, relying on alone may fail ablate primary tumors. Phototherapy is a promising modality that offers an elegant solution eradicate tumors through simple application light irradiation meanwhile triggers responses by immunogenic cell death enhance antitumor immunity. Uniting phototherapy with been found achieve synergistic outcomes, promote regression, even attain immunologic memory. This review summarizes recent studies utilizing combinatorial approaches treat cancer. A variety nanoplatforms have investigated combination immunoadjuvants checkpoint blockades such as CTLA4 PD‐L1 pathways. Higher levels proinflammatory cytokines, improved migration dendritic cells, increased ratio tumor‐infiltrating cytotoxic T cells against regulatory are revealed many studies, offering glimpse into mechanistic principles. Future advancements targeting different checkpoints could offer better immunosuppression coupled other phototherapeutic strategies remain be explored accomplishing complete elimination

Language: Английский

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Tumor Microenvironment‐Responsive Mesoporous MnO₂‐Coated Upconversion Nanoplatform for Self‐Enhanced Tumor Theranostics

Advanced Functional Materials, Journal Year: 2018, Volume and Issue: 28(36)

Published: July 13, 2018

Abstract The insufficient blood flow and oxygen supply in solid tumor cause hypoxia, which leads to low sensitivity of tumorous cells thus causing poor treatment outcome. Here, mesoporous manganese dioxide (mMnO 2 ) with ultrasensitive biodegradability a microenvironment (TME) is grown on upconversion photodynamic nanoparticles for not only TME‐enhanced bioimaging drug release, but also relieving thereby markedly improving therapy (PDT). In this nanoplatform, silica coated (UCNPs@mSiO covalently loaded chlorin e6 are obtained as near‐infrared light mediated PDT agents, then mMnO shell via facile ultrasonic way. Because its unique structure, the nanoplatform postmodified polyethylene glycol can load chemotherapeutic doxorubicin (DOX). When used antitumor application, degrades rapidly within TME, releasing Mn 2+ ions, couple trimodal (upconversion luminescence, computed tomography (CT), magnetic resonance imaging) imaging UCNPs perform self‐enhanced imaging. Significantly, degradation brings an efficient DOX relieve hypoxia by simultaneously inducing decomposition endogenous H O reduction glutathione, achieving highly potent chemo‐photodynamic therapy.

Language: Английский

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