Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications

ACS Central Science, Journal Year: 2020, Volume and Issue: 6(12), P. 2179 - 2195

Published: Dec. 14, 2020

Carbon dots (CDs), as a new type of carbon-based nanomaterial, have attracted broad research interest for years, because their diverse physicochemical properties and favorable attributes like good biocompatibility, unique optical properties, low cost, ecofriendliness, abundant functional groups (e.g., amino, hydroxyl, carboxyl), high stability, electron mobility. In this Outlook, we comprehensively summarize the classification CDs based on analysis formation mechanism, micro-/nanostructure property features, describe synthetic methods including strong absorption, photoluminescence, phosphorescence. Furthermore, recent significant advances in applications, (sensor, anticounterfeiting), energy (light-emitting diodes, catalysis, photovoltaics, supercapacitors), promising biomedicine, are systematically highlighted. Finally, envisage key issues to be challenged, future directions, perspectives show full picture CDs-based materials.

Language: Английский

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A multifunctional chemical toolbox to engineer carbon dots for biomedical and energy applications

Nature Nanotechnology, Journal Year: 2022, Volume and Issue: 17(2), P. 112 - 130

Published: Feb. 1, 2022

Language: Английский

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The light of carbon dots: From mechanism to applications

Matter, Journal Year: 2022, Volume and Issue: 5(1), P. 110 - 149

Published: Jan. 1, 2022

Language: Английский

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Smart nanoparticles for cancer therapy

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 3, 2023

Abstract Smart nanoparticles, which can respond to biological cues or be guided by them, are emerging as a promising drug delivery platform for precise cancer treatment. The field of oncology, nanotechnology, and biomedicine has witnessed rapid progress, leading innovative developments in smart nanoparticles safer more effective therapy. In this review, we will highlight recent advancements including polymeric dendrimers, micelles, liposomes, protein cell membrane mesoporous silica gold iron oxide quantum dots, carbon nanotubes, black phosphorus, MOF others. We focus on their classification, structures, synthesis, intelligent features. These possess the ability various external internal stimuli, such enzymes, pH, temperature, optics, magnetism, making them systems. Additionally, review explore latest studies tumor targeting functionalizing surfaces with tumor-specific ligands like antibodies, peptides, transferrin, folic acid. also summarize different types options, small molecules, proteins, nucleic acids, even living cells, potential use While is promising, acknowledge challenges clinical prospects associated use. Finally, propose blueprint that involves artificial intelligence-powered treatment applications. By harnessing aims usher new era personalized therapy, providing patients individualized options.

Language: Английский

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Recent advances in selective photothermal therapy of tumor

Journal of Nanobiotechnology, Journal Year: 2021, Volume and Issue: 19(1)

Published: Oct. 24, 2021

Photothermal therapy (PTT), which converts light energy to heat energy, has become a new research hotspot in cancer treatment. Although researchers have investigated various ways improve the efficiency of tumor ablation treat cancer, PTT may cause severe damage normal tissue due systemic distribution photothermal agents (PTAs) body and inaccurate laser exposure during To further survival rate patients reduce possible side effects on other parts body, it is still necessary explore PTAs with high selectivity precise In this review, we summarized strategies treatment PTT, such as increasing accumulation at sites endowing self-regulating conversion function. The views challenges selective were discussed, especially prospects their clinical applications.

Language: Английский

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Recent Advances in Synthesis, Optical Properties, and Biomedical Applications of Carbon Dots

ACS Applied Bio Materials, Journal Year: 2019, Volume and Issue: 2(6), P. 2317 - 2338

Published: May 6, 2019

Carbon dots (CDs) are relatively new and one of the most propitious nanomaterials ever known to humanity, primarily consisting a carbonized carbon core with heteroatoms in organic functional groups attached. CDs show various fascinating properties, such as tunable excitation/emission, chemical inertness, photostability, low toxicity, good biocompatibility, ease handling, eco-friendliness. Due anomalous optical properties CDs, they have wide range applications fields bioimaging, biosensing, photocatalysis, optoelectronics, etc. In this Review, we intend cover many strides chemistry, which is an emerging paradigm, conjunction recent discoveries near-infrared fluorescence, phosphorescence, electroluminescence, chirality, antibacterial activity. Our main emphasis will be on contemporary evolution synthetic strategies, biomedical nanomedicine nanotheranostics.

Language: Английский

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Red carbon dots: Optical property regulations and applications

Materials Today, Journal Year: 2019, Volume and Issue: 30, P. 52 - 79

Published: June 5, 2019

Language: Английский

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Carbon Dots in Bioimaging, Biosensing and Therapeutics: A Comprehensive Review

Small Science, Journal Year: 2022, Volume and Issue: 2(6)

Published: May 8, 2022

Carbon dots (CDs), comprising crystalline graphitized carbon cores and polymer surface groups, are currently attracting a lot of interest in biological fields owing to their fluorescent properties, high photostability, biocompatibility low toxicity. In addition, the easy preparation functionalization CDs stimulate development CDs‐based composite materials with specific functions. Presently, applications growing at remarkable speed, justifying need for up‐to‐date review articles that capture recent progress this blossoming field. review, breakthroughs synthesis, modification, optical toxicology biocatalytic platforms described. Further, research related bioimaging, biosensing, drug delivery, antibacterial, anticancer (photothermal therapy, photodynamic therapy synergistic therapy) antiviral therapies involving discussed detail. Finally, perspective on prospects challenges biomedicine biotechnology is provided.

Language: Английский

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Photonic Carbon Dots as an Emerging Nanoagent for Biomedical and Healthcare Applications

ACS Nano, Journal Year: 2020, Volume and Issue: 14(6), P. 6470 - 6497

Published: May 22, 2020

As a class of carbon-based nanomaterials, carbon dots (CDs) have attracted enormous attention because their tunable optical and physicochemical properties, such as absorptivity photoluminescence from ultraviolet to near-infrared, high photostability, biocompatibility, aqueous dispersity. These characteristics make CDs promising alternative photonic nanoagent conventional fluorophores in disease diagnosis, treatment, healthcare managements. This review describes the fundamental photophysical properties highlights recent applications bioimaging, photomedicine (e.g., photodynamic/photothermal therapies), biosensors, devices. We discuss current challenges future prospects give an insight into developing vibrant fields CD-based biomedicine healthcare.

Language: Английский

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UV–Vis–NIR Full‐Range Responsive Carbon Dots with Large Multiphoton Absorption Cross Sections and Deep‐Red Fluorescence at Nucleoli and In Vivo

Small, Journal Year: 2020, Volume and Issue: 16(19)

Published: April 13, 2020

Abstract Carbon dots (CDs), with excellent optical property and cytocompatibility, are an ideal class of nanomaterials applied in the field biomedicine. However, weak response CDs near‐infrared (NIR) region impedes their practical applications. Here, UV–vis–NIR full‐range responsive fluorine nitrogen doped (N‐CDs‐F) designed synthesized that own a favorable donor‐π‐acceptor (D‐π‐A) configuration exhibit two‐photon (λ ex = 1060 nm), three‐photon 1600 four‐photon 2000 nm) excitation upconversion fluorescence. D‐π‐A‐conjugated prepared by solvothermal synthesis under assistance ammonia fluoride reported endowed larger multiphoton absorption (MPA) cross sections (3PA: 9.55 × 10 −80 cm 6 s 2 photon −2 , 4PA: 6.32 8 3 −3 ) than conventional organic compounds. Furthermore, N‐CDs‐F show bright deep‐red to NIR fluorescence both vitro vivo, can even stain nucleoli tumor cells. A plausible mechanism is proposed on basis strong inter‐dot intra‐dot hydrogen bonds through NH···F facilitate expanding conjugated sp domains, thus not only result lower highest occupied molecular orbital‐lowest unoccupied orbital energy level but also MPA those undoped CDs.

Language: Английский

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