Intelligent Hollow Pt-CuS Janus Architecture for Synergistic Catalysis-Enhanced Sonodynamic and Photothermal Cancer Therapy

Nano Letters, Journal Year: 2019, Volume and Issue: 19(6), P. 4134 - 4145

Published: May 14, 2019

As a noninvasive treatment modality, ultrasound (US)-triggered sonodynamic therapy (SDT) shows broad and promising applications to overcome the drawbacks of traditional photodynamic (PDT) in combating cancer. However, SDT efficacy is still not satisfactory without oxygen (O2) assistance. In addition, there also much space explore SDT-based synergistic therapeutic modalities. Herein, novel Pt-CuS Janus composed hollow semiconductor CuS noble metallic Pt was rationally designed successfully synthesized. The large inner cavity for loading sonosensitizer molecules (tetra-(4-aminophenyl) porphyrin, TAPP) implement SDT. Moreover, deposition only enhances photothermal performance compared with those nanoparticles (NPs) due effect local electric field enhancement but possesses nanozyme activity catalyzing decomposition endogenous overexpressed hydrogen peroxide (H2O2) produce O2 that can tumor hypoxia augment SDT-induced highly toxic reactive species (ROS) production efficient cancer cell apoptosis. Importantly, generated heat by 808 nm laser irradiation accelerate catalytic elevate level further facilitates efficacy. Interestingly, thermally sensitive copolymer coated around act as smart switch regulate ability control TAPP release has significant on modulating effect. catalysis-enhanced efficiency almost realized complete resection obvious reoccurrence simultaneously displayed biosafety. Furthermore, high optical absorbance allows as-synthesized photoacoustic (PA) imaging NIR thermal imaging. This work develops versatile nanoplatform multifunctional theranostic strategy broadens biological designing their structure.

Language: Английский

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The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(4), P. 1253 - 1321

Published: Jan. 1, 2020

Bismuth-containing nanomaterials offer a new opportunity to move beyond current achievements in the fields of drug delivery, diagnosis, cancer therapy, biosensing, and tissue engineering. This review describes emerging applications perspective these nanoparticles.

Language: Английский

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X-ray-activated nanosystems for theranostic applications

Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(11), P. 3073 - 3101

Published: Jan. 1, 2019

X-rays are widely applied in clinical medical facilities for radiotherapy (RT) and biomedical imaging. However, the sole use of cancer treatment leads to insufficient radiation energy deposition due low X-ray attenuation coefficients living tissues organs, producing unavoidable excessive doses with serious side effects healthy body parts. Over past decade, developments materials science nanotechnology have led rapid progress field X-ray-activated tumor-targeting nanosystems, which able tackle even systemic tumors relieve burden exposure large doses. Additionally, novel imaging contrast agents techniques also been developed. In comparison conventional external light sources (e.g., near infrared), technique is ideal activation nanosystems applications its nearly unlimited penetration depth organisms. this review, we systematically describe interaction mechanisms between provide an overview X-ray-sensitive recent on cancer-associated theranostic applications.

Language: Английский

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Yolk–Shell Structured Au Nanostar@Metal–Organic Framework for Synergistic Chemo-photothermal Therapy in the Second Near-Infrared Window

Nano Letters, Journal Year: 2019, Volume and Issue: 19(10), P. 6772 - 6780

Published: Sept. 9, 2019

Light-sensitive yolk–shell nanoparticles (YSNs) as remote-controlled and stimuli-responsive theranostic platforms provide an attractive method for synergistic cancer therapy. Herein, a kind of novel multifunctional YSNs has been successfully constructed by integrating star-shaped gold (Au star) the second near-infrared (NIR-II) photothermal yolks biodegradable crystalline zeolitic imidazolate framework-8 (ZIF-8) shells. In this platform, chemotherapeutic drug (doxorubicin hydrochloride, DOX) was encapsulated into cavity, which can show behavior controlled release due to degradation process ZIF-8 in mildly acidic tumor microenvironment. Upon 1064 nm (NIR-II biowindow) laser irradiation, nanostar@ZIF-8 (Au@MOF) exhibited outstanding anticancer effect based on their promoted cargo properties. Moreover, strong NIR region absorbance endows Au@MOF thermal imaging photoacoustic (PA) This work contributes design "all-in-one" nanocarrier that realizes bimodal diagnosis chemo-photothermal

Language: Английский

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Nanomaterial-induced ferroptosis for cancer specific therapy

Coordination Chemistry Reviews, Journal Year: 2019, Volume and Issue: 382, P. 160 - 180

Published: Jan. 3, 2019

Language: Английский

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Stimuli-responsive nano-assemblies for remotely controlled drug delivery

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 322, P. 566 - 592

Published: April 8, 2020

Language: Английский

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Nanoarchitecture-Integrated Hydrogel Systems toward Therapeutic Applications

ACS Nano, Journal Year: 2023, Volume and Issue: 17(9), P. 7953 - 7978

Published: April 18, 2023

Hydrogels, as one of the most feasible soft biomaterials, have gained considerable attention in therapeutic applications by virtue their tunable properties including superior patient compliance, good biocompatibility and biodegradation, high cargo-loading efficiency. However, hydrogel application is still limited some challenges like inefficient encapsulation, easy leakage loaded cargoes, lack controllability. Recently, nanoarchitecture-integrated systems were found to be therapeutics with optimized properties, extending bioapplication. In this review, we briefly presented category hydrogels according synthetic materials further discussed advantages Additionally, various nanoarchitecture hybrid biomedical engineering are systematically summarized, cancer therapy, wound healing, cardiac repair, bone regeneration, diabetes obesity therapy. Last, current challenges, limitations, future perspectives development flexible addressed.

Language: Английский

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Immunotoxicity of metal and metal oxide nanoparticles: from toxic mechanisms to metabolism and outcomes

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(12), P. 4151 - 4183

Published: Jan. 1, 2023

Metal and metal oxide NPs may have toxic effects on the immune system through a variety of different mechanisms.

Language: Английский

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Nanoparticle contrast agents for X‐ray imaging applications

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2020, Volume and Issue: 12(6)

Published: May 22, 2020

Abstract X‐ray imaging is the most widely used diagnostic method in modern medicine and several advanced forms of this technology have recently emerged. Iodinated molecules barium sulfate suspensions are clinically approved contrast agents used. However, these existing provide limited information, suboptimal for new techniques developing safety concerns. Thus, over past 15 years, there has been a rapid growth development nanoparticles as agents. Nanoparticles desirable features such high payloads, potential long circulation times, tunable physicochemical properties. also range biomedical applications disease treatment, targeted imaging, cell tracking. In review, we discuss principles behind generation introduce types modalities, well elements chemical compositions that suitable novel agent development. We focus on progress nanoparticle developed to be renally clearable, circulating, theranostic, targeted, or feature conjunction with newly multi‐energy computed tomography mammographic technologies. Finally, offer perspectives current limitations emerging research topics expectations future field. This article categorized under: Diagnostic Tools > vivo Nanodiagnostics Imaging Nanotechnology Approaches Biology Nanoscale Systems

Language: Английский

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Cyanine-Assisted Exfoliation of Covalent Organic Frameworks in Nanocomposites for Highly Efficient Chemo-Photothermal Tumor Therapy

ACS Applied Materials & Interfaces, Journal Year: 2019, Volume and Issue: 11(43), P. 39503 - 39512

Published: Oct. 3, 2019

Covalent organic frameworks (COFs) have received considerable interest because of their advanced applications. However, low dispersibility and aqueous stability are intractable issues limiting biomedical application. To address the issue, water-dispersible nanocomposites (COF@IR783) produced through assembly cyanines COFs proposed prepared. Therefore, a strategy "killing three birds with one stone" is developed. First, exhibit superior compared to COFs. The nanosized morphology negative charges, which in favor improving blood circulation enhanced permeability retention-mediated tumor-targeting delivery therapy for vivo Second, photothermal (PTT) ability near-infrared region cyanines. also photoacoustic imaging ability, can guide antitumor vivo. Lastly, be further used as drug-delivery carriers loading anticancer cis-aconityl-doxorubicin (CAD) prodrug. In comparison individual PTT or chemotherapy, combination chemotherapy achieved COF@IR783@CAD synergistically induced death cancer cells vitro, an intravenous injection mice resulted significant tumor ablation. This work indicates that appropriately overcome rational design expand applications

Language: Английский

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