Photodynamic therapy for hypoxic tumors: Advances and perspectives

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 438, P. 213888 - 213888

Published: March 16, 2021

Language: Английский

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Recent Advances in Glucose‐Oxidase‐Based Nanocomposites for Tumor Therapy

Small, Journal Year: 2019, Volume and Issue: 15(51)

Published: Nov. 20, 2019

Abstract Glucose oxidase (GOx) can react with intracellular glucose and oxygen (O 2 ) to produce hydrogen peroxide (H O gluconic acid, which cut off the nutrition source of cancer cells consequently inhibit their proliferation. Therefore, GOx is recognised as an ideal endogenous oxido‐reductase for starvation therapy. This process further regulate tumor microenvironment by increasing hypoxia acidity. Thus, offers new possibilities elaborate design multifunctional nanocomposites However, natural expensive prepare purify exhibits immunogenicity, short in vivo half‐life, systemic toxicity. Furthermore, highly prone degrade after exposure biological conditions. These intrinsic shortcomings will undoubtedly limit its biomedical applications. Accordingly, some nanocarriers be used protect from surrounding environment, thus controlling or preserving activity. A variety including hollow mesoporous silica nanoparticles, metal–organic frameworks, organic polymers, magnetic nanoparticles are summarized construction GOx‐based multimodal synergistic In addition, current challenges promising developments this area highlighted.

Language: Английский

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Metal–Organic‐Framework‐Engineered Enzyme‐Mimetic Catalysts

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(49)

Published: Oct. 30, 2020

Nanomaterial-based enzyme-mimetic catalysts (Enz-Cats) have received considerable attention because of their optimized and enhanced catalytic performances selectivities in diverse physiological environments compared with natural enzymes. Recently, owing to molecular/atomic-level centers, high porosity, large surface area, loading capacity, homogeneous structure, metal–organic frameworks (MOFs) emerged as one the most promising materials engineering Enz-Cats. Here, recent advances design MOF-engineered Enz-Cats, including preparation methods, composite constructions, structural characterizations, biomedical applications, are highlighted commented upon. In particular, performance, selectivities, essential mechanisms, potential structure–property relations these Enz-Cats accelerating reactions discussed. Some applications also breifly proposed. These include, for example, tumor therapies, bacterial disinfection, tissue regeneration, biosensors. Finally, future opportunities challenges emerging research frontiers thoroughly Thereby, pathways perspectives designing state-of-the-art sciences offered.

Language: Английский

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A Glucose/Oxygen‐Exhausting Nanoreactor for Starvation‐ and Hypoxia‐Activated Sustainable and Cascade Chemo‐Chemodynamic Therapy

Small, Journal Year: 2020, Volume and Issue: 16(31)

Published: June 15, 2020

Abstract Fenton reaction‐mediated chemodynamic therapy (CDT) can kill cancer cells via the conversion of H 2 O to highly toxic HO•. However, problems such as insufficient levels in tumor tissue and low reaction efficiency severely limit performance CDT. Here, prodrug tirapazamine (TPZ)‐loaded human serum albumin (HSA)–glucose oxidase (GOx) mixture is prepared modified with a metal–polyphenol network composed ferric ions (Fe 3+ ) tannic acid (TA), obtain self‐amplified nanoreactor termed HSA–GOx–TPZ–Fe –TA (HGTFT) for sustainable cascade exogenous production TA‐accelerated Fe /Fe 2+ conversion. The HGTFT efficiently convert oxygen into HO• CDT, consume glucose starvation therapy, provide hypoxic environment TPZ radical‐mediated chemotherapy. Besides, it revealed that significantly elevate intracellular reactive species content hypoxia level, decrease glutathione content, release metal tumors ion interference (also “ion‐interference therapy” or “metal therapy”). Further, also increase tumor’s level inhibit growth. It believed this microenvironment‐regulable anticancer excellent biosafety represents an advance nanomedicine.

Language: Английский

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Advances in nanomedicine for cancer starvation therapy

Theranostics, Journal Year: 2019, Volume and Issue: 9(26), P. 8026 - 8047

Published: Jan. 1, 2019

Abnormal cell metabolism with vigorous nutrition consumption is one of the major physiological characteristics cancers. As such, strategy cancer starvation therapy through blocking blood supply, depleting glucose/oxygen and other critical nutrients tumors has been widely studied to be an attractive way for treatment. However, several undesirable properties these agents, such as low targeting efficacy, undesired systemic side effects, elevated tumor hypoxia, induced drug resistance, increased metastasis risk, limit their future applications. The recent development starving-nanotherapeutics combined therapeutic methods displayed promising potential overcoming above drawbacks. This review highlights advances nanotherapeutic-based discusses challenges prospects anticancer strategies.

Language: Английский

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Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: April 6, 2022

Abstract Natural enzymes usually suffer from high production cost, ease of denaturation and inactivation, low yield, making them difficult to be broadly applicable. As an emerging type artificial enzyme, nanozymes that combine the characteristics nanomaterials are promising alternatives. On one hand, have enzyme-like catalytic activities regulate biochemical reactions. other also inherit properties nanomaterials, which can ameliorate shortcomings natural serve as versatile platforms for diverse applications. In this review, various mimic activity different introduced. The achievements in cancer diagnosis treatment technologies summarized by highlighting advantages these Finally, future research directions rapidly developing field outlooked."Image missing"

Language: Английский

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Biocatalytic Nanomaterials: A New Pathway for Bacterial Disinfection

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(33)

Published: July 3, 2021

Clinical treatment of pathogenic infection has emerged as a growing challenge in global public health. Such is currently limited to antibiotics, but abuse antibiotics have induced multidrug resistance and high fatality rates anti-infection therapies. Thus, it vital develop alternative bactericidal agents open novel disinfection pathways. Drawing inspiration from elements the human immune system that show great potential for controlling pathogens or regulating cell apoptosis, design biocatalytic nanomaterials (BCNs) provided unrivaled opportunities future antibacterial More significantly, BCNs exhibit various superior properties cells natural enzymes, such higher performance, extraordinary stability against harsh conditions, scalable production. In this review, most recent efforts toward developing BCN-based biomedical applications combating bacterial infections are focused upon. BCNs' mechanisms, classification BCNs, activities can be triggered augmented by energy conversion, eradication biofilms with systematically introduced discussed. The current challenges prospects also summarized. It anticipated review will provide new therapeutic insights into bacteria offer significant designing nanomaterials.

Language: Английский

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Glucose Oxidase-Instructed Traceable Self-Oxygenation/Hyperthermia Dually Enhanced Cancer Starvation Therapy

Theranostics, Journal Year: 2020, Volume and Issue: 10(4), P. 1544 - 1554

Published: Jan. 1, 2020

Cancer theranostics based on glucose oxidase (GOx)-induced starvation therapy has got more and attention in cancer management.Herein, GOx armed manganese dioxide nanosheets (denoted as MNS-GOx) were developed nanotheranostic agent for magnetic resonance (MR)/photoacoustic (PA) dual-modal imaging guided self-oxygenation/hyperthermia dually enhanced therapy.The nanomaterials with different morphologies (such nanoflowers, nanowires) synthesized by a biomimetic approach using melanin biotemplate.Afterwards, the (MNS) two sides large surface area selected vehicle to carry deliver GOx.The as-prepared MNS-GOx can perform circular reaction of oxidation H 2 O decomposition therapy.Moreover, catalytic activity could be further improved hyperthermia upon near-infrared laser irradiation.Most intriguingly, achieve "turn-on" MR "turn-off" PA simultaneously.The theranostic capability was evaluated A375 tumor-bearing mice all tumor elimination.Our findings integrated molecular starvation-based synergistic therapy, which provided new platform nanotheranostics.

Language: Английский

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Biodegradable Calcium Phosphate Nanotheranostics with Tumor‐Specific Activatable Cascade Catalytic Reactions‐Augmented Photodynamic Therapy

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(14)

Published: Jan. 27, 2021

Abstract Photodynamic therapy (PDT) is exploited as a promising strategy for cancer treatment. However, the hypoxic solid tumor and lack of tumor‐specific photosensitizer administration hinder further application oxygen (O 2 )‐dependent PDT. In this study, biodegradable O self‐supplying nanoplatform microenvironment (TME)‐specific activatable cascade catalytic reactions‐augmented PDT reported. The (named GMCD) constructed by coloading catalase (CAT) sinoporphyrin sodium (DVDMS) in manganese (Mn)‐doped calcium phosphate mineralized glucose oxidase (GOx) nanoparticles. GMCD can effectively accumulate sites to achieve an “off on” fluorescence transduction TME‐activatable magnetic resonance imaging. After internalization into cells, endogenous hydrogen peroxide (H ) be catalyzed generate CAT, which not only promotes GOx reaction consume more intratumoral glucose, but also alleviates hypoxia enhances production cytotoxic singlet from light‐triggered DVDMS. Moreover, H generated GOx‐catalysis converted highly toxic hydroxyl radicals Mn 2+ ‐mediated Fenton‐like reaction, amplifying oxidative damage cells. As result, displays superior therapeutic effects on 4T1‐tumor bearing mice long term reactions augmented

Language: Английский

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A Robust Narrow Bandgap Vanadium Tetrasulfide Sonosensitizer Optimized by Charge Separation Engineering for Enhanced Sonodynamic Cancer Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(36)

Published: July 23, 2021

The development and optimization of sonosensitizers for elevating intratumoral reactive oxygen species (ROS) are definitely appealing in current sonodynamic therapy (SDT). Given this, branched vanadium tetrasulfide (VS4 ) nanodendrites with a narrower bandgap (compared the most extensively explored sonosensitizers) presented as new source sonosensitizer, which allows more effortless separation sono-triggered electron-hole pairs ROS generation. Specifically, platinum (Pt) nanoparticles endogenous high levels glutathione (GSH) rationally engineered to further optimize its sono-sensitized performance. As cocatalyst, Pt is conducive trapping electrons, whereas GSH, natural hole-scavenger, tends capture holes. Compared pristine VS4 GSH-Pt-VS4 nanocomposite can greatly prolong lifetime charge confer highly efficacious production activity. Furthermore, such nanoplatforms capable reshaping tumor microenvironments realize overproduction, contributed by overcoming hypoxia improve SDT-triggered singlet production, catalyzing endogenic hydrogen peroxide into destructive hydroxyl radicals chemodynamic therapy, depleting GSH amplify oxidative stress. All these combined effects result significantly efficient suppression outcome. This study enriches sonosensitizer research proves that be optimized engineering strategy.

Language: Английский

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