Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(4)

Published: Dec. 2, 2020

Abstract The past decades have witnessed hyperthermia therapy (HTT) as an emerging strategy against malignant tumors. Nanomaterial‐based photothermal (PTT) and magnetic (MHT), highly effective noninvasive treatment models, offer advantages over other strategies in the of different types However, both PTT MHT cannot completely cure cancer due to recurrence distal metastasis. In recent years, immunotherapy has attracted widespread attention owing its capability activate body's own natural defense identify, attack, eradicate cells. Significant efforts been devoted studying activated immune responses caused by hyperthermia‐ablated this article, synergistic mechanism HTT immunotherapy, including immunogenic cell death reversal immunosuppressive tumor microenvironment is discussed. reports combination or HTT‐based multimodal with immunoadjuvant exploitation, checkpoint blockade therapy, adoptive cellular are summarized. As highlighted, these could achieve synergistically enhanced therapeutic outcomes primary tumors metastatic lesions, prevent recurrence, prolong survival period. Finally, current challenges prospective developments HTT‐synergized also reviewed.

Language: Английский

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An Enzyme‐Engineered Nonporous Copper(I) Coordination Polymer Nanoplatform for Cuproptosis‐Based Synergistic Cancer Therapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(43)

Published: Sept. 2, 2022

Abstract Cuproptosis, a newly identified form of regulated cell death that is copper‐dependent, offers great opportunities for exploring the use copper‐based nanomaterials inducing cuproptosis cancer treatment. Here, glucose oxidase (GOx)‐engineered nonporous copper(I) 1,2,4‐triazolate ([Cu(tz)]) coordination polymer (CP) nanoplatform, denoted as GOx@[Cu(tz)], starvation‐augmented and photodynamic synergistic therapy developed. Importantly, catalytic activity GOx shielded in scaffold but can be “turned on” efficient depletion only upon glutathione (GSH) stimulation cells, thereby proceeding starvation therapy. The GSH sensitizes cells to GOx@[Cu(tz)]‐mediated cuproptosis, producing aggregation lipoylated mitochondrial proteins, target copper‐induced toxicity. increased intracellular hydrogen peroxide (H 2 O ) levels, due oxidation glucose, activates type I (PDT) efficacy GOx@[Cu(tz)]. vivo experimental results indicate GOx@[Cu(tz)] produces negligible systemic toxicity inhibits tumor growth by 92.4% athymic mice bearing 5637 bladder tumors. This thought first report cupreous nanomaterial capable cuproptosis‐based cancer, which should invigorate studies pursuing rational design efficacious strategies based on cuproptosis.

Language: Английский

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Au2Pt-PEG-Ce6 nanoformulation with dual nanozyme activities for synergistic chemodynamic therapy / phototherapy

Biomaterials, Journal Year: 2020, Volume and Issue: 252, P. 120093 - 120093

Published: May 10, 2020

Language: Английский

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Advances in oxidase-mimicking nanozymes: Classification, activity regulation and biomedical applications

Nano Today, Journal Year: 2021, Volume and Issue: 37, P. 101076 - 101076

Published: Jan. 14, 2021

Language: Английский

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Tumor‐Microenvironment‐Activated Reactive Oxygen Species Amplifier for Enzymatic Cascade Cancer Starvation/Chemodynamic /Immunotherapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(4)

Published: Oct. 26, 2021

At present, some progress has been made in the field of cancer theranostics based on nanocatalysts (NCs), but achieving precise response to specific tumor microenvironment (TME) remains a major challenge. Herein, TME-responsive upconversion nanoparticles (UCNPs)-based smart UCNPs@Cu-Cys-GOx (UCCG) nanosystem is engineered, which combines natural enzymes and nanozymes so as amplify reactive oxygen species (ROS) generation situ for starvation/chemodynamic/immunotherapy. One biggest merits this material that it can be preserved inert (off) normal tissues, only TME specifically activated (on) through series enzymatic cascades boost ROS production via strategy open source (H2 O2 self-supplying ability) reduce expenditure (glutathione (GSH) consuming ability). More importantly, enhanced oxidative stress by UCCG NCs reverses immunosuppressive TME, facilitates antitumor immune responses. Meanwhile, starvation/chemodynamic synergistic therapy triggered combined with PD-L1 antibody effectively inhibits growth primary tumors metastasis. In addition, UCNPs present luminescence enhancement, exploited visualize reinforced real time. Collectively, work provides an original method devising exploitation UCNPs-based catalytic immunotherapy.

Language: Английский

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A Nanomedicine Fabricated from Gold Nanoparticles‐Decorated Metal–Organic Framework for Cascade Chemo/Chemodynamic Cancer Therapy

Advanced Science, Journal Year: 2020, Volume and Issue: 7(17)

Published: June 14, 2020

The incorporation of new modalities into chemotherapy greatly enhances the anticancer efficacy combining merits each treatment, showing promising potentials in clinical translations. Herein, a hybrid nanomedicine (Au/FeMOF@CPT NPs) is fabricated using metal-organic framework (MOF) nanoparticles and gold (Au as building blocks for cancer chemo/chemodynamic therapy. MOF NPs are used vehicles to encapsulate camptothecin (CPT), hybridization by Au improves stability physiological environment. Triggered high concentration phosphate inside cells, Au/FeMOF@CPT effectively collapse after internalization, resulting complete drug release activation cascade catalytic reactions. intracellular glucose can be oxidized produce hydrogen dioxide, which further utilized chemical fuel Fenton reaction, thus realizing synergistic efficacy. Benefitting from enhanced permeability retention effect sophisticated fabrications, blood circulation time tumor accumulation significantly increased. In vivo results demonstrate that combination chemodynamic therapy suppresses growth, meantime systemic toxicity this avoided.

Language: Английский

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Fusiform-Like Copper(II)-Based Metal–Organic Framework through Relief Hypoxia and GSH-Depletion Co-Enhanced Starvation and Chemodynamic Synergetic Cancer Therapy

ACS Applied Materials & Interfaces, Journal Year: 2020, Volume and Issue: 12(15), P. 17254 - 17267

Published: March 31, 2020

The therapeutic effect of traditional chemodynamic therapy (CDT) agents is severely restricted by their weakly acidic pH and glutathione (GSH) overexpression in the tumor microenvironment. Here, fusiform-like copper(II)-based tetrakis(4-carboxy phenyl)porphyrin (TCPP) nanoscale metal–organic frameworks (nMOFs) were designed constructed for first time (named PCN-224(Cu)-GOD@MnO2). coated MnO2 layer can not only avoid conjugation glucose oxidase (GOD) to damage normal cells but also catalyzes generation O2 from H2O2 enhance oxidation (Glu) GOD, which provides abundant subsequent Cu+-based Fenton-like reaction. Meanwhile, Cu2+ chelated TCPP ligand converted Cu+ excess GSH tumor, reduces antioxidant activity improve CDT effect. Next, reacts with plentiful enzyme catalysis produce a toxic hydroxyl radical (•OH), singlet oxygen (1O2) synchronously generated combination Cu+, O2, H2O via Russell mechanism. Furthermore, nanoplatform be used both TCPP-based vivo fluorescence imaging Mn2+-induced T1-weighted magnetic resonance imaging. In conclusion, PCN-224(Cu)-GOD@MnO2 nMOFs facilitate efficiency starvation relief hypoxia depletion after acting as an accurate guide.

Language: Английский

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Nanocatalyst‐Mediated Chemodynamic Tumor Therapy

Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 11(2)

Published: Nov. 9, 2021

Abstract Traditional tumor treatments, including chemotherapy, radiotherapy, photodynamic therapy, and photothermal are developed used to treat different types of cancer. Recently, chemodynamic therapy (CDT) has been emerged as a novel cancer therapeutic strategy. CDT utilizes Fenton or Fenton‐like reaction generate highly cytotoxic hydroxyl radicals (•OH) from endogenous hydrogen peroxide (H 2 O ) kill cells, which displays promising potentials for treatment. However, the low catalytic efficiency off‐target side effects limit biomedical application CDT. In this regard, various strategies implemented potentiate against tumor, retrofitting microenvironment (e.g., increasing H level, decreasing reductive substances, reducing pH), enhancing nanocatalysts, other strategies. This review aims summarize development these recent progresses nanocatalyst‐mediated antitumor application. The future trend challenges also discussed.

Language: Английский

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One-Step Integration of Tumor Microenvironment-Responsive Calcium and Copper Peroxides Nanocomposite for Enhanced Chemodynamic/Ion-Interference Therapy

ACS Nano, Journal Year: 2021, Volume and Issue: 16(1), P. 617 - 630

Published: Dec. 27, 2021

Recently, various metal peroxide nanomaterials have drawn increasing attention as an efficient hydrogen (H2O2) self-supplying agent for enhanced tumor therapy. However, a single kind of is insufficient to achieve more effective antitumor performance. Here, hyaluronic acid modified calcium and copper peroxides nanocomposite has been synthesized by simple one-step strategy. After accumulation at the site due permeability retention (EPR) effect specific recognition hyaluronate with CD44 protein on surface cells, plenty Ca2+, Cu2+, H2O2 can be simultaneously released in hyaluronidase overexpressed microenvironment (TME), generating abundant hydroxyl radical through Fenton-type reaction between Cu2+ assistance glutathione depletion. Overloaded Ca2+ lead mitochondria injury thus enhance oxidative stress cells. Moreover, unbalanced transport channel caused further promote calcification necrosis, which generally defined ion-interference As result, synergistic Fenton-like dysfunction ROS generation performed. Therefore, TME-responsive based integration successfully established exhibits satisfactory efficiency than any peroxide.

Language: Английский

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Cerium Oxide Nanoparticles: Advances in Biodistribution, Toxicity, and Preclinical Exploration

Small, Journal Year: 2020, Volume and Issue: 16(20)

Published: April 24, 2020

Antioxidant nanoparticles have recently gained tremendous attention for their enormous potential in biomedicine. However, discrepant reports of either medical benefits or toxicity, and lack reproducibility many studies, generate uncertainties delaying effective implementation. Herein, the case cerium oxide is considered, a well-known catalyst petrochemistry industry one first antioxidant proposed medicine. Like other nanoparticles, it now described as promising therapeutic alternative, threatening to health. Sources these discrepancies how this analysis helps overcome contradictions found are summarized discussed. For context analysis, what has been reported liver reviewed, where diseases related oxidative stress. Since well-dispersed passively accumulate liver, represents major testing field study new nanomedicines clinical translation. Even more, contradictory works cerium-oxide-associated toxicity protection against stress inflammation. Based on this, finally, intention propose solutions design improved that will work more precisely medicine safely society.

Language: Английский

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