A Novel Pt–TiO₂ Heterostructure with Oxygen‐Deficient Layer as Bilaterally Enhanced Sonosensitizer for Synergistic Chemo‐Sonodynamic Cancer Therapy

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(13)

Published: Feb. 14, 2020

Abstract Sonodynamic therapy (SDT) activated by ultrasound is attractive as a potential alternative to conventional phototriggered therapies owing the deeper penetration depth and absence of phototoxicity. Nevertheless, low quantum yield nano‐sonosensitizer tumor hypoxia remain significant challenges for SDT. Herein, novel TiO 2 ‐based reported bilaterally enhance simultaneous integration precious metal Pt nanoparticles (NPs) an oxygen‐deficient layer. Furthermore, hollow cavity serves reservoir load doxorubicin, anticancer drug chemotherapy well molecular sonosensitizer The decorated NPs act nanozymes catalyze decomposition endogenous hydrogen peroxide generation oxygen alleviate hypoxia, reduce resistance chemotherapy, provide sufficient source subsequently facilitating SDT‐induced reactive species production. high chemo‐sonodynamic synergistic efficacy systematically demonstrated both in vitro vivo. More importantly, it believed that design new finding synthesis Pt–TiO heterostructures can be popularized preparation application semiconductor‐based nanoplatforms many fields.

Language: Английский

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Nanozymes: Activity origin, catalytic mechanism, and biological application

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 448, P. 214170 - 214170

Published: Aug. 26, 2021

Language: Английский

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<p>Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles</p>

International Journal of Nanomedicine, Journal Year: 2020, Volume and Issue: Volume 15, P. 6827 - 6838

Published: Sept. 1, 2020

Abstract: The ultimate goal of phototherapy based on nanoparticles, such as photothermal therapy (PTT) which generates heat and photodynamic (PDT) not only reactive oxygen species (ROS) but also induces a variety anti-tumor immunity, is to kill tumors. In addition, due strong efficacy in clinical treatment with minimal invasion negligible side effects, it has received extensive attention research recent years. this paper, the generations nanomaterials PTT PDT are described separately. application, according different combination pathway can be used treat diseases tumors, melanoma, rheumatoid so on. mechanism pathological detail terms inducing apoptosis cancer cells by ROS produced PDT, immunogenic cell death provoke maturation dendritic cells, turn activate production CD4+ T CD8+T memory well inhibiting shock protein (HSPs), STAT3 signal Keywords: mechanism, therapy, PTT,

Language: Английский

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Janus particles: design, preparation, and biomedical applications

Materials Today Bio, Journal Year: 2019, Volume and Issue: 4, P. 100033 - 100033

Published: Sept. 1, 2019

Janus particles with an anisotropic structure have emerged as a focus of intensive research due to their diverse composition and surface chemistry, which show excellent performance in various fields, especially biomedical applications. In this review, we briefly introduce the structures, composition, properties particles, followed by summary Then review several design strategies including morphology, particle size, modification, that will affect particles. Subsequently, explore synthetic methodologies emphasis on most prevalent method (surface nucleation seeded growth). Following this, highlight applications, drug delivery, bio-imaging, bio-sensing. Finally, consider current challenges materials face perspectives future directions.

Language: Английский

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Newly developed strategies for improving sonodynamic therapy

Materials Horizons, Journal Year: 2020, Volume and Issue: 7(8), P. 2028 - 2046

Published: Jan. 1, 2020

Sonodynamic therapy (SDT) is a new therapeutic method, which can kill malignant tumors by using sonosensitizers and low intensity ultrasound (US) simultaneously.

Language: Английский

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Advances and perspectives in organic sonosensitizers for sonodynamic therapy

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 445, P. 214087 - 214087

Published: June 28, 2021

Language: Английский

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Manganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis in hypoxic tumors

Theranostics, Journal Year: 2020, Volume and Issue: 11(4), P. 1937 - 1952

Published: Dec. 16, 2020

Development of efficient therapeutic strategy to incorporate ultrasound (US)-triggered sonodynamic therapy (SDT) and ferroptosis is highly promising in cancer therapy. However, the SDT efficacy severely limited by hypoxia high glutathione (GSH) tumor microenvironment, associated with reactive oxygen species (ROS) GSH depletion. Methods: A manganese porphyrin-based metal-organic framework (Mn-MOF) was constructed as a nanosensitizer self-supply (O2) decrease for enhanced ferroptosis. In vitro vivo analysis, including characterization, O2 generation, depletion, ROS lipid peroxidation, antitumor immune microenvironment were systematically evaluated. Results: Mn-MOF exhibited catalase-like decreasing activity vitro. After internalization into cells, persistently catalyzed tumor-overexpressed H2O2 in-situ produce relieve GPX4, which facilitated formation kill cells upon US irradiation hypoxic tumors. Thus, strong anticancer anti-metastatic found H22 4T1 tumor-bearing mice after single administration irradiation. addition, showed immunity improved immunosuppressive increasing numbers activated CD8+ T matured dendritic decreaing myeloid-derived suppressor tissues. Conclusions: holds great potential

Language: Английский

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Transformable Nanosensitizer with Tumor Microenvironment‐Activated Sonodynamic Process and Calcium Release for Enhanced Cancer Immunotherapy

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(25), P. 14051 - 14059

Published: April 2, 2021

Abstract Despite the promise of sonodynamic processes in cancer therapy, existing sonosensitizers often fail to regulate generation reactive oxygen species (ROS) against tumors, potentially leading off‐target toxicity normal tissues. We report a transformable core‐shell nanosonosensitizer (TiO 2 @CaP) that reinvigorates ROS and dissolves its CaP shell release Ca 2+ an acidic tumor microenvironment (TME) under ultrasound activation. Thus, TiO @CaP acts as smart specifically induces mitochondrial dysfunction via overloading intracellular ions synergize with process TME. substantially enhances immunogenic cell death, resulting enhanced T‐cell recruitment infiltration into cold (4T1). In conjunction checkpoint blockade therapy (anti‐PD 1), @CaP‐mediated elicits systemic antitumor immunity, regression non‐treated distant tumors inhibition lung metastasis. This work paves way development “smart” TME‐activatable temporospatial control over responses.

Language: Английский

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Ultrasound‐Activated Oxygen and ROS Generation Nanosystem Systematically Modulates Tumor Microenvironment and Sensitizes Sonodynamic Therapy for Hypoxic Solid Tumors

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 29(51)

Published: Oct. 14, 2019

Abstract Sonodynamic therapy (SDT) is noninvasive and possesses high body‐penetration depth, showing great potential for the treatment of deep‐seated solid tumors. The efficacy SDT, however, limited by widespread hypoxia in Given this, an ultrasound‐activated nanosystem developed integrating ferrate(VI) protoporphyrin IX into biodegradable hollow mesoporous organosilica nanoplatforms, followed assembling a phase‐change material lauric acid. effectively reacts with water as well overexpressed hydrogen peroxide glutathione (GSH) tumor cells, leading to tumor‐microenvironment‐independent oxygen production situ GSH depletion More importantly, significant reactive species (ROS) overproduction simultaneously achieved protoporphyrin‐augmented SDT intracellular Fenton chemistry. Furthermore, mild hyperthermia induced ultrasound can trigger phase change acid, achieving ultrasound‐responsive control over release ROS, GSH. simultaneous generation, depletion, ROS play synergetic role sensitizing toward hypoxic tumors, which verified remarkable improvement environments more growth inhibition against osteosarcoma both vitro vivo, promising application treatment.

Language: Английский

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Janus Nanoparticles: From Fabrication to (Bio)Applications

ACS Nano, Journal Year: 2021, Volume and Issue: 15(4), P. 6147 - 6191

Published: March 19, 2021

Janus nanoparticles (JNPs) refer to the integration of two or more chemically discrepant composites into one structure system. Studies JNPs have been significant interest due their interesting characteristics stemming from asymmetric structures, which can integrate different functional properties and perform synergetic functions simultaneously. Herein, we present recent progress particles, comprehensively detailing fabrication strategies applications. First, classification is divided three blocks, consisting polymeric composites, inorganic hybrid polymeric/inorganic composites. Then, are alternately summarized, examining self-assembly strategy, phase separation seed-mediated polymerization, microfluidic preparation nucleation growth methods, masking methods. Finally, various intriguing applications presented, including solid surfactants agents, micro/nanomotors, biomedical such as biosensing, controlled drug delivery, bioimaging, cancer therapy, combined theranostics. Furthermore, challenges future works in this field provided.

Language: Английский

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