Manganese Dioxide Coated Piezoelectric Nanosonosensitizer for Cancer Therapy with Tumor Microenvironment Remodeling and Multienzyme‐Like Catalysis DOI

Zhaoyang Yue,

Qinyu Zhao, Shaobo Wang

et al.

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

Abstract Sonodynamic therapy (SDT) as an emerging method for cancer has encountered difficulty in insufficient production of reactive oxygen species (ROS), especially tumor microenvironment (TME) with elevated antioxidants and hypoxic conditions. In this work, the authors have fabricated heterostructured manganese dioxide (MnO 2 )‐coated BaTiO 3 nanoparticles (BTO@M NPs) a piezoelectric sonosensitizer, which exhibits capacity remodeling TME multienzyme‐like catalysis boosting SDT. Benefitting from piezotronic effect, formation p ‐ n junction between MnO BTO built‐in electric field band bending efficiently promotes separation charge carriers, facilitating generation superoxide anion (•O − ) hydroxyl radical (•OH) under ultrasound (US) stimulation. Moreover, BTO@M NPs can catalyze overexpressed hydrogen peroxide (H O to produce replenishing gas source SDT, also deplete antioxidant glutathione (GSH), realizing remodeling. During process, reduced Mn(II) convert H into •OH, further amplifying cellular oxidative damage. With these combination effects, versatile exhibit prominent cytotoxicity growth inhibition against 4T1 breast cancer. This work provides feasible strategy constructing high‐efficiency sonosensitizers

Language: Английский

Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy DOI Creative Commons
Bijiang Geng, Jinyan Hu, Yuan Li

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 30, 2022

Theranostic sonosensitizers with combined sonodynamic and near infrared (NIR) imaging modes are required for guided therapy (SDT). It is challenging, however, to realize a single material that simultaneously endowed both NIR emitting activities. Herein, we report the design of class NIR-emitting from phosphorescent carbon dot (CD) narrow bandgap (1.62 eV) long-lived excited triplet states (11.4 μs), two which can enhance SDT as thermodynamically dynamically favorable factors under low-intensity ultrasound irradiation, respectively. The NIR-phosphorescent CDs identified bipolar quantum dots containing p- n-type surface functionalization regions drive spatial separation e--h+ pairs fast transfer reaction sites. Importantly, cancer-specific targeting high-level intratumor enrichment theranostic achieved by cancer cell membrane encapsulation precision complete eradication solid tumors injection irradiation. These results will open up promising approach engineer materials tumor therapy.

Language: Английский

Citations

234
Triarylboron‐Doped Acenethiophenes as Organic Sonosensitizers for Highly Efficient Sonodynamic Therapy with Low Phototoxicity DOI

Kanglei Liu,

Zhenqi Jiang,

Fenggui Zhao

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(49)

Published: Oct. 4, 2022

The development of efficient organic sonosensitizers is crucial for sonodynamic therapy (SDT) in the field cancer treatment. Herein, a new strategy based on triarylboron-doped acenethiophene scaffolds presented. attachment boron to linear acenethiophenes lowers lowest unoccupied molecular orbital (LUMO) energy, resulting redshifted absorptions and emissions. After encapsulation with amphiphilic polymer DSPE-mPEG2000 , it found that nanostructured BAnTh-NPs BTeTh-NPs (nanoparticles BAnTh BTeTh) shows hydroxyl radical (• OH) generation under ultrasound (US) irradiation aqueous solution almost no phototoxicity, which can overcome shortcomings O2 -dependent SDT avoid potential cutaneous phototoxicity issue. In vitro vivo therapeutic results validate boron-doped as enable high efficiency low good biocompatibility, indicating boron-functionalization acenes promising toward SDT.

Language: Английский

Citations

157
Porphyrin-Based Two-Dimensional Layered Metal–Organic Framework with Sono-/Photocatalytic Activity for Water Decontamination DOI
Zhong‐Hong Zhu, Yubo Liu,

Chi Song

et al.

ACS Nano, Journal Year: 2021, Volume and Issue: 16(1), P. 1346 - 1357

Published: Dec. 27, 2021

Water treatment is crucial to improve the water quality and reduce diarrheal chronological diseases caused by excessive discharge of organic dyes other waste. The development expansion efficient catalysts for degradation sterilization has attracted widespread attention. Herein, we report an example a porphyrin-based two-dimensional layered metal-organic framework (MOF) (2DZnTcpp) its sono-/photocatalytic bactericidal activity. dislocated layers effectively avoid close π-π stacking provide porous space oxygen/water/dye contact. introduction Zn ions increases spin orbital coupling through heavy atom effect promotes intersystem crossing process singlet oxygen generation. effective ligand-to-metal charge transfer open catalytic sites also facilitate splitting hydroxyl radical These features together promote reactive species (ROS) generation 2DZnTcpp under light illumination or ultrasound sonication. It worth noting that with high specific surface area porosity shows dye Moreover, could largely inactivate Escherichia coli irradiation (the power 1 sun) sonication 30 min efficiencies over 99.99999%. This work provides approach design synthesis MOF-based sono-/photocatalysts used in purification textile wastewater committed establishment more efficient, fast, environmentally friendly system.

Language: Английский

Citations

114
Synthesis strategies, luminescence mechanisms, and biomedical applications of near-infrared fluorescent carbon dots DOI
Yuqing Wang,

Xiangcao Li,

Shaojing Zhao

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 470, P. 214703 - 214703

Published: July 13, 2022

Language: Английский

Citations

108
Conferring BiVO4 Nanorods with Oxygen Vacancies to Realize Enhanced Sonodynamic Cancer Therapy DOI

Zhuang Yang,

Meng Yuan, Bin Liu

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(44)

Published: Sept. 9, 2022

Abstract Owing to the high depth of tissue penetration, non‐invasiveness, and controllability, ultrasound (US)‐mediated sonodynamic therapy (SDT) has shown broad application prospects for tumor treatment. However, electron‐hole separation inefficiency sonosensitizers hypoxia remain two major challenges limiting effect SDT. Here, ultrafine photoetched bismuth vanadate (BiVO 4 ) nanorods modified with DSPE‐PEG 2000 (PEBVO@PEG NRs) were fabricated achieve in situ self‐supply oxygen (O 2 reactive species (ROS) hypoxic therapy. The photoetching approach could enhance charge by inducing enriched vacancies on surface BiVO , thereby improving generation efficiency ROS O . PEBVO@PEG overcome main obstacles traditional SDT process show promising therapeutic effects, thus providing new strategies performance sonosensitizer elimination.

Language: Английский

Citations

105
The promising interplay between sonodynamic therapy and nanomedicine DOI
Roberto Canaparo, Federica Foglietta, Nadia Barbero

et al.

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 189, P. 114495 - 114495

Published: Aug. 17, 2022

Language: Английский

Citations

95
Exploiting the Twisted Intramolecular Charge Transfer Effect to Construct a Wash-Free Solvatochromic Fluorescent Lipid Droplet Probe for Fatty Liver Disease Diagnosis DOI
Chengjuan Wu, Xinyu Li, Ting Zhu

et al.

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(9), P. 3881 - 3887

Published: Feb. 22, 2022

The prominent pathological feature of fatty liver disease lesions is excessive fat accumulation in lipid droplets hepatocytes. Thus, developing fluorescent droplet-specific probes with high permeability and a imaging contrast provides robust tool for diagnosing diseases. Herein, we rationally developed novel donor-acceptor lipophilic probe ANI photostability wash-free visualization characteristics. showed typical twisted intramolecular charge transfer effect very faint fluorescence high-polar solvents, but dramatically boosted emissions low-polar environments. solvatochromic can selectively light up manner. Further use to reveal the significantly large size tissues from model mice was successfully demonstrated. remarkable performances rendered an alternative accurately evaluating intraoperative diagnosis.

Language: Английский

Citations

90
Emerging carbon-supported single-atom catalysts for biomedical applications DOI Creative Commons
Guangfu Liao, Li Zhang, Chunxue Li

et al.

Matter, Journal Year: 2022, Volume and Issue: 5(10), P. 3341 - 3374

Published: Oct. 1, 2022

Language: Английский

Citations

83
Recent developments of sonodynamic therapy in antibacterial application DOI
Ruhao Wang, Qianwen Liu, Ang Gao

et al.

Nanoscale, Journal Year: 2022, Volume and Issue: 14(36), P. 12999 - 13017

Published: Jan. 1, 2022

This review summarizes the currently available sonosensitizers for antibacterial SDT and digs into innovative biotechnologies to improve efficiency.

Language: Английский

Citations

81
Immunosonodynamic Therapy Designed with Activatable Sonosensitizer and Immune Stimulant Imiquimod DOI

Huali Lei,

Ji Hyeon Kim, Subin Son

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(7), P. 10979 - 10993

Published: June 19, 2022

Sonodynamic therapy (SDT) has garnered extensive attention as a noninvasive treatment for deep tumors. Furthermore, imiquimod (R837), an FDA-approved toll-like receptor 7 agonist, is commonly used in clinical settings immune adjuvant. We prepared activatable sonodynamic sensitizer platform (MR) based on glutathione-sensitive disulfide bonds linking Leu-MB, the reduced form of methylene blue (MB), and R837 to achieve efficient combinatory SDT immunotherapy tumors without harming normal tissues. also amphiphilic polymer C18PMH-PEG create self-assembled MB-R837-PEG (MRP) nanoparticles immunosonodynamic (iSDT). iSDT cancer that combines immunotherapy. Our demonstrated excellent effect only at tumor site, demonstrating high specificity killing cells when compared reported literature. The improves its tumor-killing by inducing response, which accomplished secreted adjuvants site. MRP was selectively activated glutathione microenvironment release MB R837, exhibiting antitumor responses. In addition, combined with α-PD-L1 antibody checkpoint blockade, this effectively inhibited metastasis. mice treated did not develop even after reinoculation, indicating long-term memory achieved. concept preparation next-generation synergistic therapeutic modality applicable near future presented study.

Language: Английский

Citations

77