Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(30)
Published: June 17, 2021
Recently,
enzyme
dynamic
therapy
(EDT)
has
drawn
much
attention
as
a
new
type
of
therapy.
However,
the
selection
suitable
nanocarriers
to
deliver
chloroperoxidase
(CPO)
and
enhancement
level
hydrogen
peroxide
(H
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(8), P. 5086 - 5125
Published: Jan. 1, 2021
Some
infectious
or
malignant
diseases
such
as
cancers
are
seriously
threatening
the
health
of
human
beings
all
over
world.
The
commonly
used
antibiotic
therapy
cannot
effectively
treat
these
within
a
short
time,
and
also
bring
about
adverse
effects
drug
resistance
immune
system
damage
during
long-term
systemic
treatment.
Phototherapy
is
an
emerging
antibiotic-free
strategy
to
diseases.
Upon
light
irradiation,
phototherapeutic
agents
can
generate
cytotoxic
reactive
oxygen
species
(ROS)
induce
temperature
increase,
which
leads
death
targeted
cells.
These
two
kinds
killing
strategies
referred
photodynamic
(PDT)
photothermal
(PTT),
respectively.
So
far,
many
photo-responsive
have
been
developed.
Among
them,
metal-organic
framework
(MOF)
becoming
one
most
promising
materials
because
its
structure
chemical
compositions
be
easily
modulated
achieve
specific
functions.
MOFs
intrinsic
ability
under
rational
design
MOF
construction,
serve
carrier
therapeutic
agents,
owing
tunable
porosity.
provide
feasibility
for
various
combined
therapies
targeting
methods,
improves
efficiency
phototherapy.
In
this
review,
we
firstly
investigated
principles
phototherapy,
comprehensively
summarized
recent
advances
in
PDT,
PTT
synergistic
therapy,
from
construction
modification.
We
expect
that
our
demonstration
will
shed
on
future
development
field,
it
step
closer
clinical
trials.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Feb. 22, 2022
Nanozyme
is
a
series
of
nanomaterials
with
enzyme-mimetic
activities
that
can
proceed
the
catalytic
reactions
natural
enzymes.
In
field
biomedicine,
nanozymes
are
capturing
tremendous
attention
due
to
their
high
stability
and
low
cost.
Enzyme-mimetic
be
regulated
by
multiple
factors,
such
as
chemical
state
metal
ion,
pH,
hydrogen
peroxide
(H2O2),
glutathione
(GSH)
level,
presenting
great
promise
for
biomedical
applications.
Over
past
decade,
multi-functional
have
been
developed
various
To
promote
understandings
development
novel
multifunctional
nanozymes,
we
herein
provide
comprehensive
review
applications
in
field.
Nanozymes
versatile
enzyme-like
properties
briefly
overviewed,
mechanism
application
discussed
future
research.
Finally,
underlying
challenges
prospects
frontier
this
review.
Analytical Chemistry,
Journal Year:
2020,
Volume and Issue:
92(4), P. 3373 - 3379
Published: Jan. 16, 2020
Single-atom
nanozymes
(SAzymes),
as
novel
with
atomically
dispersed
active
sites,
are
of
great
importance
in
the
development
for
their
high
catalytic
activities,
maximum
utilization
efficiency
metal
atoms,
and
simple
model
sites.
Herein,
peroxidase-like
SAzymes
high-concentration
Cu
sites
on
carbon
nanosheets
(Cu–N–C)
were
synthesized
through
a
salt-template
strategy.
With
densely
distributed
atoms
(∼5.1
wt
%),
Cu–N–C
exhibit
remarkable
activity
to
mimic
natural
peroxidase.
Integrating
acetylcholinesterase
choline
oxidase,
three-enzyme-based
cascade
reaction
system
was
constructed
colorimetric
detection
acetylcholine
organophosphorus
pesticides.
This
work
not
only
provides
strategy
synthesize
abundant
but
also
gives
some
new
insights
robust
nanozyme
biosensing
systems.
Small,
Journal Year:
2019,
Volume and Issue:
15(51)
Published: Nov. 20, 2019
Abstract
Glucose
oxidase
(GOx)
can
react
with
intracellular
glucose
and
oxygen
(O
2
)
to
produce
hydrogen
peroxide
(H
O
gluconic
acid,
which
cut
off
the
nutrition
source
of
cancer
cells
consequently
inhibit
their
proliferation.
Therefore,
GOx
is
recognised
as
an
ideal
endogenous
oxido‐reductase
for
starvation
therapy.
This
process
further
regulate
tumor
microenvironment
by
increasing
hypoxia
acidity.
Thus,
offers
new
possibilities
elaborate
design
multifunctional
nanocomposites
However,
natural
expensive
prepare
purify
exhibits
immunogenicity,
short
in
vivo
half‐life,
systemic
toxicity.
Furthermore,
highly
prone
degrade
after
exposure
biological
conditions.
These
intrinsic
shortcomings
will
undoubtedly
limit
its
biomedical
applications.
Accordingly,
some
nanocarriers
be
used
protect
from
surrounding
environment,
thus
controlling
or
preserving
activity.
A
variety
including
hollow
mesoporous
silica
nanoparticles,
metal–organic
frameworks,
organic
polymers,
magnetic
nanoparticles
are
summarized
construction
GOx‐based
multimodal
synergistic
In
addition,
current
challenges
promising
developments
this
area
highlighted.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(2), P. 3105 - 3118
Published: Jan. 18, 2022
The
clinical
application
of
photothermal
therapy
(PTT)
is
severely
limited
by
the
tissue
penetration
depth
excitation
light,
and
enzyme
hampered
its
low
therapeutic
efficiency.
As
a
two-dimensional
ultrathin
nanosheet
with
high
absorbance
in
near-infrared-II
(NIR-II)
region,
titanium
carbide
(Ti3C2)
can
be
used
as
substrate
to
anchor
functional
components,
like
nanozymes
nanodrugs.
Here,
we
decorate
Pt
artificial
on
Ti3C2
nanosheets
synthesize
Ti-based
MXene
nanocomposites
(Ti3C2Tx-Pt-PEG).
In
tumor
microenvironment,
nanoparticles
exhibit
peroxidase-like
(POD-like)
activity,
which
situ
catalyze
hydrogen
peroxide
generate
hydroxyl
radicals
(•OH)
induce
cell
apoptosis
necrosis.
Meanwhile,
composite
shows
desirable
effect
upon
NIR-II
light
irradiation
power
density
(0.75
W
cm-2).
Especially,
POD-like
activity
significantly
enhanced
elevated
temperature
arising
from
Ti3C2Tx.
Therefore,
satisfactory
synergistic
PTT/enzyme
has
been
accomplished,
accompanied
an
applicable
photoacoustic
imaging
capability
monitor
guide
process.
This
work
may
provide
approach
for
hyperthermia-amplified
nanozyme
catalytic
therapy,
especially
based
metal
catalysts
nanocomposites.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(49)
Published: Oct. 30, 2020
Nanomaterial-based
enzyme-mimetic
catalysts
(Enz-Cats)
have
received
considerable
attention
because
of
their
optimized
and
enhanced
catalytic
performances
selectivities
in
diverse
physiological
environments
compared
with
natural
enzymes.
Recently,
owing
to
molecular/atomic-level
centers,
high
porosity,
large
surface
area,
loading
capacity,
homogeneous
structure,
metal–organic
frameworks
(MOFs)
emerged
as
one
the
most
promising
materials
engineering
Enz-Cats.
Here,
recent
advances
design
MOF-engineered
Enz-Cats,
including
preparation
methods,
composite
constructions,
structural
characterizations,
biomedical
applications,
are
highlighted
commented
upon.
In
particular,
performance,
selectivities,
essential
mechanisms,
potential
structure–property
relations
these
Enz-Cats
accelerating
reactions
discussed.
Some
applications
also
breifly
proposed.
These
include,
for
example,
tumor
therapies,
bacterial
disinfection,
tissue
regeneration,
biosensors.
Finally,
future
opportunities
challenges
emerging
research
frontiers
thoroughly
Thereby,
pathways
perspectives
designing
state-of-the-art
sciences
offered.