A Tumor‐Microenvironment‐Responsive Nanocomposite for Hydrogen Sulfide Gas and Trimodal‐Enhanced Enzyme Dynamic Therapy DOI
Bin Liu, Shuang Liang, Zhao Wang

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(30)

Published: June 17, 2021

Recently, enzyme dynamic therapy (EDT) has drawn much attention as a new type of therapy. However, the selection suitable nanocarriers to deliver chloroperoxidase (CPO) and enhancement level hydrogen peroxide (H

Language: Английский

The recent progress on metal–organic frameworks for phototherapy DOI

Qiyao Zheng,

Xiangmei Liu, Yufeng Zheng

et al.

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(8), P. 5086 - 5125

Published: Jan. 1, 2021

Some infectious or malignant diseases such as cancers are seriously threatening the health of human beings all over world. The commonly used antibiotic therapy cannot effectively treat these within a short time, and also bring about adverse effects drug resistance immune system damage during long-term systemic treatment. Phototherapy is an emerging antibiotic-free strategy to diseases. Upon light irradiation, phototherapeutic agents can generate cytotoxic reactive oxygen species (ROS) induce temperature increase, which leads death targeted cells. These two kinds killing strategies referred photodynamic (PDT) photothermal (PTT), respectively. So far, many photo-responsive have been developed. Among them, metal-organic framework (MOF) becoming one most promising materials because its structure chemical compositions be easily modulated achieve specific functions. MOFs intrinsic ability under rational design MOF construction, serve carrier therapeutic agents, owing tunable porosity. provide feasibility for various combined therapies targeting methods, improves efficiency phototherapy. In this review, we firstly investigated principles phototherapy, comprehensively summarized recent advances in PDT, PTT synergistic therapy, from construction modification. We expect that our demonstration will shed on future development field, it step closer clinical trials.

Language: Английский

Citations

392

Nanozymes-recent development and biomedical applications DOI Creative Commons
Xiangyi Ren, Dongxu Chen, Yan Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Feb. 22, 2022

Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed the catalytic reactions natural enzymes. In field biomedicine, nanozymes are capturing tremendous attention due to their high stability and low cost. Enzyme-mimetic be regulated by multiple factors, such as chemical state metal ion, pH, hydrogen peroxide (H2O2), glutathione (GSH) level, presenting great promise for biomedical applications. Over past decade, multi-functional have been developed various To promote understandings development novel multifunctional nanozymes, we herein provide comprehensive review applications in field. Nanozymes versatile enzyme-like properties briefly overviewed, mechanism application discussed future research. Finally, underlying challenges prospects frontier this review.

Language: Английский

Citations

285

Au2Pt-PEG-Ce6 nanoformulation with dual nanozyme activities for synergistic chemodynamic therapy / phototherapy DOI
Man Wang, Mengyu Chang, Qing Chen

et al.

Biomaterials, Journal Year: 2020, Volume and Issue: 252, P. 120093 - 120093

Published: May 10, 2020

Language: Английский

Citations

270

Photodynamic therapy for hypoxic tumors: Advances and perspectives DOI
Huang Li,

Shaojing Zhao,

Jiasheng Wu

et al.

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 438, P. 213888 - 213888

Published: March 16, 2021

Language: Английский

Citations

260

Cascade Reaction System Integrating Single-Atom Nanozymes with Abundant Cu Sites for Enhanced Biosensing DOI
Yu Wu, Jiabin Wu, Lei Jiao

et al.

Analytical Chemistry, Journal Year: 2020, Volume and Issue: 92(4), P. 3373 - 3379

Published: Jan. 16, 2020

Single-atom nanozymes (SAzymes), as novel with atomically dispersed active sites, are of great importance in the development for their high catalytic activities, maximum utilization efficiency metal atoms, and simple model sites. Herein, peroxidase-like SAzymes high-concentration Cu sites on carbon nanosheets (Cu–N–C) were synthesized through a salt-template strategy. With densely distributed atoms (∼5.1 wt %), Cu–N–C exhibit remarkable activity to mimic natural peroxidase. Integrating acetylcholinesterase choline oxidase, three-enzyme-based cascade reaction system was constructed colorimetric detection acetylcholine organophosphorus pesticides. This work not only provides strategy synthesize abundant but also gives some new insights robust nanozyme biosensing systems.

Language: Английский

Citations

257

Recent Advances in Glucose‐Oxidase‐Based Nanocomposites for Tumor Therapy DOI
Man Wang, Dongmei Wang, Qing Chen

et al.

Small, Journal Year: 2019, Volume and Issue: 15(51)

Published: Nov. 20, 2019

Abstract Glucose oxidase (GOx) can react with intracellular glucose and oxygen (O 2 ) to produce hydrogen peroxide (H O gluconic acid, which cut off the nutrition source of cancer cells consequently inhibit their proliferation. Therefore, GOx is recognised as an ideal endogenous oxido‐reductase for starvation therapy. This process further regulate tumor microenvironment by increasing hypoxia acidity. Thus, offers new possibilities elaborate design multifunctional nanocomposites However, natural expensive prepare purify exhibits immunogenicity, short in vivo half‐life, systemic toxicity. Furthermore, highly prone degrade after exposure biological conditions. These intrinsic shortcomings will undoubtedly limit its biomedical applications. Accordingly, some nanocarriers be used protect from surrounding environment, thus controlling or preserving activity. A variety including hollow mesoporous silica nanoparticles, metal–organic frameworks, organic polymers, magnetic nanoparticles are summarized construction GOx‐based multimodal synergistic In addition, current challenges promising developments this area highlighted.

Language: Английский

Citations

251

Pt Decorated Ti3C2Tx MXene with NIR-II Light Amplified Nanozyme Catalytic Activity for Efficient Phototheranostics DOI
Yanlin Zhu, Zhao Wang, Ruoxi Zhao

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 3105 - 3118

Published: Jan. 18, 2022

The clinical application of photothermal therapy (PTT) is severely limited by the tissue penetration depth excitation light, and enzyme hampered its low therapeutic efficiency. As a two-dimensional ultrathin nanosheet with high absorbance in near-infrared-II (NIR-II) region, titanium carbide (Ti3C2) can be used as substrate to anchor functional components, like nanozymes nanodrugs. Here, we decorate Pt artificial on Ti3C2 nanosheets synthesize Ti-based MXene nanocomposites (Ti3C2Tx-Pt-PEG). In tumor microenvironment, nanoparticles exhibit peroxidase-like (POD-like) activity, which situ catalyze hydrogen peroxide generate hydroxyl radicals (•OH) induce cell apoptosis necrosis. Meanwhile, composite shows desirable effect upon NIR-II light irradiation power density (0.75 W cm-2). Especially, POD-like activity significantly enhanced elevated temperature arising from Ti3C2Tx. Therefore, satisfactory synergistic PTT/enzyme has been accomplished, accompanied an applicable photoacoustic imaging capability monitor guide process. This work may provide approach for hyperthermia-amplified nanozyme catalytic therapy, especially based metal catalysts nanocomposites.

Language: Английский

Citations

249

MOF-derived Co3O4@Co-Fe oxide double-shelled nanocages as multi-functional specific peroxidase-like nanozyme catalysts for chemo/biosensing and dye degradation DOI
Qiumeng Chen, Xiaodan Zhang, Siqi Li

et al.

Chemical Engineering Journal, Journal Year: 2020, Volume and Issue: 395, P. 125130 - 125130

Published: April 20, 2020

Language: Английский

Citations

238

Nanoscale covalent organic frameworks: from controlled synthesis to cancer therapy DOI

Xuelu He,

Zhenqi Jiang, Ozioma Udochukwu Akakuru

et al.

Chemical Communications, Journal Year: 2021, Volume and Issue: 57(93), P. 12417 - 12435

Published: Jan. 1, 2021

The controlled synthesis methods and the applications of nanoscale covalent organic frameworks in cancer therapy are summarized this feature article.

Language: Английский

Citations

237

Metal–Organic‐Framework‐Engineered Enzyme‐Mimetic Catalysts DOI
Lang Ma,

Fuben Jiang,

Xin Fan

et al.

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(49)

Published: Oct. 30, 2020

Nanomaterial-based enzyme-mimetic catalysts (Enz-Cats) have received considerable attention because of their optimized and enhanced catalytic performances selectivities in diverse physiological environments compared with natural enzymes. Recently, owing to molecular/atomic-level centers, high porosity, large surface area, loading capacity, homogeneous structure, metal–organic frameworks (MOFs) emerged as one the most promising materials engineering Enz-Cats. Here, recent advances design MOF-engineered Enz-Cats, including preparation methods, composite constructions, structural characterizations, biomedical applications, are highlighted commented upon. In particular, performance, selectivities, essential mechanisms, potential structure–property relations these Enz-Cats accelerating reactions discussed. Some applications also breifly proposed. These include, for example, tumor therapies, bacterial disinfection, tissue regeneration, biosensors. Finally, future opportunities challenges emerging research frontiers thoroughly Thereby, pathways perspectives designing state-of-the-art sciences offered.

Language: Английский

Citations

233