Recent Advances in Visible-Light Photoredox Catalysis for the Thiol-Ene/Yne Reactions

Molecules, Journal Year: 2022, Volume and Issue: 27(3), P. 619 - 619

Published: Jan. 18, 2022

Visible-light photoredox catalysis has been established as a popular and powerful tool for organic transformations owing to its inherent characterization of environmental friendliness sustainability in the past decades. The thiol-ene/yne reactions, direct hydrothiolation alkenes/alkynes with thiols, represents one most efficient atom-economic approaches carbon-sulfur bonds construction. In traditional methodologies, harsh conditions such stoichiometric reagents or specialized UV photo-apparatus were necessary suffering from various disadvantages. particular, visible-light also demonstrated be greener milder protocol reactions recent years. Additionally, unprecedented advancements have achieved this area during decade. review, we will summarize advances catalyzed 2015 2021. Synthetic strategies, substrate scope, proposed reaction pathways are mainly discussed.

Language: Английский

---

Photoinduced radical-polar crossover cyclization reactions

Chem Catalysis, Journal Year: 2024, Volume and Issue: 4(5), P. 100945 - 100945

Published: March 5, 2024

Language: Английский

---

Photocatalytic Sulfonylation: Innovations and Applications

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: unknown

Published: July 14, 2024

Photosynthesis, converting sustainable solar energy into chemical energy, has emerged as a promising craft to achieve diverse organic transformations due its mild reaction conditions, sustainability, and high efficiency. The synthesis of sulfonated compounds drawn significant attention in the pharmaceuticals, agrochemicals, materials industries unique structure electronic properties sulfonyl groups. Over past decades, many photocatalytic sulfonylation reactions have been developed. In this review, recent advances photocatalyzed reviewed since 2020, with primary focus on discussing design mechanism.

Language: Английский

---

Metal-Catalyst-Free Radical Cyclization of 1,6-Enynes for the Selective and Switchable Synthesis of Lactams in Water

ACS Sustainable Chemistry & Engineering, Journal Year: 2022, Volume and Issue: 10(18), P. 6057 - 6062

Published: April 27, 2022

Three types of novel radical cyclization 1,6-enynes with sulfonyl hydrazides have been presented, which provided convenient synthetic approaches for accessing five-membered cyclic lactams, lactams containing C–I bond, and six-membered lactams. Notably, these transformations are implemented in metal-catalyst-free systems, three classes important lactam derivatives were synthesized selectivity controllability from the same substrate using water as green solvent.

Language: Английский

---

Photoinduced cascade cyclization of alkynes with NH₄SCN: access to SCN-containing dibenzazepines or dioxodibenzothiazepines

Green Chemistry, Journal Year: 2022, Volume and Issue: 24(12), P. 4742 - 4747

Published: Jan. 1, 2022

Photoinduced tandem cyclization of alkynes with NH 4 SCN was developed for the synthesis various SCN-containing seven-membered N-heterocycles.

Language: Английский

---

Recent Advances in the Functionalization of Remote C−H Bonds by Hofmann‐Löffler‐Freytag‐type Reactions

Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 365(19), P. 3211 - 3226

Published: Aug. 26, 2023

Abstract Nitrogen radicals are one of the most useful reactive intermediates for selective transposition via intramolecular hydrogen atom transfer (HAT). The Hofmann‐Löffler‐Freytag (HLF) reaction is a distinctive radical‐based approach in which nitrogen used remote C−H bond functionalization HAT. Due to its excellent regioselectivity and atomic economy, HLF represents new preparation valuable functional molecules. In this review, we provide brief overview recent research advances mediated HLF‐type reactions involving intermolecular cyclization, δ ‐site functionalization.

Language: Английский

---

EDA Complex-Enabled Annulation to Access CF₂-Containing Tetralones and Quinazolinones Using Persulfates as Electron Donors

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(15), P. 10614 - 10623

Published: July 25, 2024

A photocatalyst-free and EDA complex-enabled radical cascade cyclization reaction of inactive alkenes with bromodifluoroacetamides was reported for the divergent synthesis fluorine-containing tetralones quinazolinones. In this transformation, persulfates as electron donors difluoro bromamide acceptors generate complex. This is a promising photochemical method advantages such mild conditions, simple operation, being metal-free, excellent functional group tolerance.

Language: Английский

---

The synthesis of seven- and eight-membered rings by radical strategies

Organic Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 9(17), P. 4757 - 4781

Published: Jan. 1, 2022

Radical strategies for preparation of seven- or eight-membered rings.

Language: Английский

---

Metal-free and site-selective α-C–H functionalization of tetrahydrofuran enabled by the photocatalytic generation of bromine radicals

Green Chemistry, Journal Year: 2022, Volume and Issue: 25(3), P. 960 - 965

Published: Nov. 3, 2022

A simple and inherent green photocatalytic approach using commercially available cheap n Bu 4 NBr with 4-CzIPN was reported to effectively initiate the site-selective α -C(sp 3 )-H activation of tetrahydrofuran for C-S C-C cross-couplings.

Language: Английский

---

Photochemical difluoromethylation of alkynes: synthesis of CF₂H-substituted seven-membered dioxodibenzothiazepines and dibenzazepines

Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(8), P. 1968 - 1974

Published: Jan. 1, 2023

A general and efficient photochemical strategy for difluoromethylation/radical cascade cyclization of alkynes with sodium difluoromethylsulfinate (NaSO 2 CF H) has been disclosed.

Language: Английский

---