The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(23), P. 16671 - 16678
Published: Nov. 16, 2023
Photoinduced silylation of silanes with 2-aryl-2H-indazoles was developed under mild conditions, which could efficiently result in diverse 3-silylated 2H-indazoles good substrate scopes. A series scaled-up to gram level and radical capture operations were performed this system. Meanwhile, a bioactive molecule tolerated well typical conditions.
Language: Английский
Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(6), P. 1220 - 1268
Published: Jan. 22, 2024
Abstract Elaborated molecular architectures, specifically those bearing one or more carbon stereocenters, stand as an important class of carbocyclic and heterocyclic frameworks because they are frequently occurring core structures in numerous natural products biologically active pharmaceutical molecules. Over the past few decades, development versatile synthetic approaches via cascade cyclization reactions 1,6‐enynes for construction a series fused spiro compounds has been focus great deal research initiatives. These synthesis strategies peculiarly fascinating context assembly wide array molecules, products, agrochemicals, functional materials. In this review, recent developments transformations with diverse coupling reagents summarized since 2018, which could be divided into five categories: 1) Introduction; 2) Transition metal catalyzed 1,6‐enynes; 3) Metal‐free 4) Visible‐light‐induced 5) Electrocatalytic 1,6‐enynes.
Language: Английский
Citations
13
Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(10), P. 2352 - 2362
Published: April 5, 2024
Abstract While the emergence of electrophotochemistry provides opportunities, such a chemistry at this stage suffers from limited reaction types and high photocatalyst loadings. A self‐catalyzed electrophotosynthesis as well one with low loading is presented. These external‐oxidant‐free cyclizations are enabling applicable to range activated alkenes, affording diverse array thiocyanato heterocycles including 4‐pyrrolin‐2‐ones, isoquinoline‐1,3‐diones, indolo[2,1‐ ]isoquinolin‐6(5 H )‐ones, benzoimidazo[2,1‐ )‐ones indolin‐2‐ones, protocols amenable late‐stage diversification complex molecular architectures gram‐scale syntheses. Sunlight could serve light source, be conducted in an all‐solar‐driven mode using commercially available photovoltaic panel produce electricity.
Language: Английский
Citations
9
Green Chemistry, Journal Year: 2022, Volume and Issue: 24(18), P. 7122 - 7130
Published: Jan. 1, 2022
Syntheses of β-keto sulfones have been reported using g-C 3 N 4 as a recyclable photocatalyst along with green chemistry metrics and eco-scale evaluation.
Language: Английский
Citations
34
Organic & Biomolecular Chemistry, Journal Year: 2023, Volume and Issue: 21(31), P. 6379 - 6388
Published: Jan. 1, 2023
Dearomative ipso -annulation of unactivated biaryl ynones using AgSCN/AgSCF 3 as the radical source in presence CAN DMSO is disclosed.
Language: Английский
Citations
17
Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(4), P. 635 - 697
Published: Jan. 13, 2024
Abstract In recent years, the interest to develop cyclizations promoted by visible light has been gaining a lot of attention due its sustainability aspect. this review, we summarize most important advances in period describing methods used generate different ring sizes, while focusing on mechanistic details these reactions.
Language: Английский
Citations
8
Green Chemistry, Journal Year: 2022, Volume and Issue: 25(1), P. 153 - 160
Published: Nov. 25, 2022
Photo-promoted cascade 6-exo-trig spirocyclization of biaryl ynones with NH 4 SCN was developed for the preparation various SCN-containing spiro[5,5]trienones.
Language: Английский
Citations
27
Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(8), P. 1968 - 1974
Published: Jan. 1, 2023
A general and efficient photochemical strategy for difluoromethylation/radical cascade cyclization of alkynes with sodium difluoromethylsulfinate (NaSO 2 CF H) has been disclosed.
Language: Английский
Citations
15
The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(7), P. 4854 - 4862
Published: March 22, 2023
A metal/peroxide-free involved simple cascade 6-exo-trig spirocyclization of tert-butyl nitrite with biaryl ynones has been finished, which resulted in various NO2-modified spiro[5,5]trienones good regioselectivity/yields. variety scaled-up experiments, reduction/epoxidation operations, and mechanistic studies were performed to verify the merits process this radical system. Finally, structure spirocycles was confirmed by single-crystal X-ray diffraction.
Language: Английский
Citations
15
Chemical Communications, Journal Year: 2024, Volume and Issue: 60(29), P. 3938 - 3941
Published: Jan. 1, 2024
A metal-free radical bicyclization of chloralkanes and 1,6-enynes produces various polychlorinated/chlorinated polyheterocycles.
Language: Английский
Citations
5
ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(6)
Published: Feb. 1, 2025
Abstract An efficient metal/peroxide‐free [5 + 1] cyclization of 2‐vinylanilines with TBN was realized to access various cinnolines high yields. In addition, benzo[ e ]pyrrolo[2,1‐c][1,2,4]triazines could also be obtained by using 2‐(1 H ‐pyrrol‐1‐yl)anilines as the raw materials. This cascade system selected common/low‐cost tert ‐butyl nitrite N1 source, which performed broad substrate scopes/simple operation/mild conditions/available scaled up 1 mmol.
Language: Английский
Citations
0