Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(22), P. 4688 - 4693
Published: Aug. 20, 2024
Abstract
Metal
hydride
catalyzed
hydrogen
atom
transfer
(MHAT)
reaction
of
1,6‐enyne
and
electron‐poor
alkene
progresses
through
a
radical
cascade,
involving
ene‐yne
cyclization
exocyclic
C−C
bond
formation
superseding
the
direct
reductive
olefin
cross‐coupling;
which
is
realized
in
current
study.
The
generality
this
manifold
demonstrated
with
range
functionalized
dienes
structurally
distinct
olefins
alkynes
as
partners.
Current
work
unveils
merger
MHAT‐based
olefin‐hydro
functionalization
ene‐one
cyclization.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(6), P. 1220 - 1268
Published: Jan. 22, 2024
Abstract
Elaborated
molecular
architectures,
specifically
those
bearing
one
or
more
carbon
stereocenters,
stand
as
an
important
class
of
carbocyclic
and
heterocyclic
frameworks
because
they
are
frequently
occurring
core
structures
in
numerous
natural
products
biologically
active
pharmaceutical
molecules.
Over
the
past
few
decades,
development
versatile
synthetic
approaches
via
cascade
cyclization
reactions
1,6‐enynes
for
construction
a
series
fused
spiro
compounds
has
been
focus
great
deal
research
initiatives.
These
synthesis
strategies
peculiarly
fascinating
context
assembly
wide
array
molecules,
products,
agrochemicals,
functional
materials.
In
this
review,
recent
developments
transformations
with
diverse
coupling
reagents
summarized
since
2018,
which
could
be
divided
into
five
categories:
1)
Introduction;
2)
Transition
metal
catalyzed
1,6‐enynes;
3)
Metal‐free
4)
Visible‐light‐induced
5)
Electrocatalytic
1,6‐enynes.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 14, 2024
Photosynthesis,
converting
sustainable
solar
energy
into
chemical
energy,
has
emerged
as
a
promising
craft
to
achieve
diverse
organic
transformations
due
its
mild
reaction
conditions,
sustainability,
and
high
efficiency.
The
synthesis
of
sulfonated
compounds
drawn
significant
attention
in
the
pharmaceuticals,
agrochemicals,
materials
industries
unique
structure
electronic
properties
sulfonyl
groups.
Over
past
decades,
many
photocatalytic
sulfonylation
reactions
have
been
developed.
In
this
review,
recent
advances
photocatalyzed
reviewed
since
2020,
with
primary
focus
on
discussing
design
mechanism.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(22), P. 5735 - 5745
Published: Jan. 1, 2023
During
the
past
decade,
photo-
and
electrochemical
reactions
proceeding
via
single-electron-transfer
(SET)
triggered
radical
pathways
have
emerged
as
an
indispensable
strategy
for
efficient
formation
of
chemical
bonds.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(4), P. 635 - 697
Published: Jan. 13, 2024
Abstract
In
recent
years,
the
interest
to
develop
cyclizations
promoted
by
visible
light
has
been
gaining
a
lot
of
attention
due
its
sustainability
aspect.
this
review,
we
summarize
most
important
advances
in
period
describing
methods
used
generate
different
ring
sizes,
while
focusing
on
mechanistic
details
these
reactions.
Chemistry - A European Journal,
Journal Year:
2022,
Volume and Issue:
28(42)
Published: May 19, 2022
We
developed
time-atom
economic
regio-
and
chemoselective
sulfonyl
radical
triggered
5-exo-dig
cyclization
of
unactivated
1,6-enynes
with
halides
under
metal,
additive-free
reaction
conditions
to
achieve
highly
substituted
five-membered
heterocyclic
compounds.
This
transformation
creates
three
new
bonds,
such
as
C-SO2
,
C-C,
active
C-I/Br
bonds.
Importantly,
one-pot
protocols
produce
desired
products
directly
from
sodium
sulfinates
have
an
additional
advantage
minimising
chemical
waste,
saving
time,
simplifying
practical
aspects
compared
existing
protocols.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(43), P. 6584 - 6587
Published: Jan. 1, 2023
We
synthesized
tetrasubstituted
olefins
regioselectively
and
stereoselectively
from
ynamides
internal
alkynes
with
sulfonyl
iodides
under
blue
LEDs
in
few
minutes.
The
key
features
are
being
metal-free,
easy
to
handle,
simple,
broad
scope,
environmentally
friendly.
Furthermore,
a
gram-scale
experiment
was
conducted,
the
corresponding
sulfonyl-iodinated
products
were
smoothly
altered
into
various
other
products.
Asian Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
12(8)
Published: June 26, 2023
Abstract
The
upsurge
in
interest
the
development
of
methodologies
for
synthesis
sulfur‐containing
compounds
via
use
visible‐light
has
been
established
as
a
sustainable
tool
organic
chemistry.
Particularly,
mediated
C−S
bond
formation
gained
popularity
due
to
its
operational
simplicity,
minimized
by‐products,
easy
handling,
mild
reaction
conditions,
etc.
Photochemistry
not
only
provides
way
synthesize
complex
molecules
but
also
ability
overcome
many
challenges
which
are
difficult
attain
by
conventional
thermal
pathways.
Owing
biological
importance
compounds,
present
review
focused
on
under
metal‐free
conditions
visible‐light.
objective
current
is
bring
out
unearthing
collection
regarding
photoredox
catalysis.
For
better
understanding,
categorized
according
mode
reactions
viz
,
difunctionalization
alkenes
and
alkynes,
C−H
functionalization,
radical
cyclization.
All
each
sections
described
with
selected
examples
proper
explanation
proposed
mechanism.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(3), P. 1145 - 1145
Published: Jan. 23, 2023
Radical
reactions
are
powerful
in
creating
carbon–carbon
and
carbon–heteroatom
bonds.
Designing
one-pot
radical
with
cascade
transformations
to
assemble
the
cyclic
skeletons
two
new
functional
groups
is
both
synthetically
operationally
efficient.
Summarized
this
paper
recent
development
of
involving
addition
cyclization
dienes,
diynes,
enynes,
as
well
arene-bridged
arene-terminated
compounds
for
preparation
difunctionalization
compounds.
Reactions
carried
out
initiators,
transition
metal-catalysis,
photoredox,
electrochemical
conditions
included.
Chemical Science,
Journal Year:
2023,
Volume and Issue:
14(13), P. 3541 - 3547
Published: Jan. 1, 2023
Radical
cascade
addition
is
one
of
the
most
important
and
efficient
strategies
for
synthesis
valuable
heterocycles
with
structural
diversity
complexity.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(22), P. 15969 - 15974
Published: Oct. 30, 2023
Described
herein
is
a
photoinduced
copper-catalyzed
1,2-difunctionalization
of
1,3-dienes.
The
selenium
atom
radical
was
generated
by
the
visible
light
irradiation
diselenides,
triggering
addition
with
1,3-dienes
to
form
allyl
intermediate.
Subsequent
rapid
Z/E
isomerization
allowed
for
thermodynamically
favorable
intermediate
formation
and
enabled
copper
catalyzed
stereoselective
functionalization
various
nucleophiles.
