Asian Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
11(9)
Published: July 25, 2022
Abstract
A
convenient
and
efficient
copper‐catalyzed
three‐component
difluoromethylation‐peroxidation
of
alkenes
with
commercially‐available
sodium
difluoromethanesulfinate
tert
‐butyl
hydroperoxide
has
been
developed.
This
protocol
enables
the
synthesis
a
variety
β
‐difluoromethyl
peroxides
under
mild
conditions.
Versatile
synthetic
transformations
difluoromethyl
have
also
explored.
Chemical Science,
Journal Year:
2023,
Volume and Issue:
14(46), P. 13367 - 13383
Published: Jan. 1, 2023
This
review
summarizes
recent
advances
in
combining
photo-
and
N-heterocyclic
carbene
catalysis,
as
well
provides
an
outlook
on
future
opportunities
challenges.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(7), P. 2112 - 2133
Published: Jan. 1, 2024
Organofluorine
compounds
are
of
high
value.
NHC-catalyzed
fluorination
and
fluoroalkylation
have
served
as
powerful
versatile
vehicles
for
accessing
the
related
organofluorines.
This
review
focuses
on
recent
developments
in
this
area.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(18), P. 4488 - 4515
Published: Jan. 1, 2023
This
review
highlights
the
recent
advances
in
radical
acylated
difunctionalization
of
unsaturated
carbon–carbon
bonds
and
focuses
on
mechanistic
insights
these
transformations.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(30), P. 5519 - 5524
Published: July 21, 2022
β-Thiolated-α-arylated
ketones
are
perversive
in
bioactive
molecules
and
serve
as
potential
bidentate
ligands
for
catalysis.
Herein,
a
straightforward
protocol
to
access
β-thiolated
from
aldehydes,
alkenes,
disulfides
enabled
by
the
combination
of
photocatalysis
N-heterocyclic
carbene
catalysis
is
reported.
The
sequential
radical
addition
alkenes
subsequent
radical–radical
coupling
cascade
process
simultaneously
forge
C–S
C–C
bonds.
mild
conditions
allow
relay
with
broad
functional
group
tolerance.
The Chemical Record,
Journal Year:
2023,
Volume and Issue:
23(9)
Published: May 22, 2023
Abstract
In
the
last
few
years,
many
reagents
and
protocols
have
been
developed
to
allow
for
efficient
fluorofunctionalization
of
a
diverse
set
scaffolds
ranging
from
alkanes,
alkenes,
alkynes,
(hetero)arenes.
The
concomitant
rise
organofluorine
chemistry
visible
light‐mediated
synthesis
synergistically
expanded
fields
mutually
benefitted
developments
in
both
fields.
this
context,
light
driven
formations
radicals
containing
fluorine
major
focus
discovery
new
bioactive
compounds.
This
review
details
recent
advances
progress
made
fluoroalkylation
heteroatom
centered
radical
generation.
European Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
26(48)
Published: Oct. 11, 2023
Abstract
N
‐Heterocyclic
carbene
(NHC)
catalyzed
radical‐radical
reactions
have
been
proven
to
be
powerful
strategies
for
assembling
ketyl‐containing
compounds
via
single
electron
transfer
(SET)
pathway
under
either
thermal
conditions
or
photoredox
conditions.
In
this
context,
acylation
of
alkenes
radical
relay
NHC‐organocatalysis
has
also
opened
a
new
window
the
difunctionalization
construct
valuable
molecules
in
organic
synthesis.
review,
advances
and
progress
were
summarized
according
different
ways
generation
key
NHC‐bound
ketyl‐type
radicals.
Furthermore,
reaction
scopes,
limitations
mechanisms
discussed
based
on
types
catalytic
systems.
Conclusions
perspectives
put
forward
at
end.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(26), P. 28129 - 28143
Published: June 19, 2024
An
efficient
and
mild
protocol
for
the
visible
light-induced
radical
cascade
difluoromethylation/cyclization
of
imidazoles
with
unactivated
alkenes
using
easily
accessible
bench-stable
difluoromethyltriphenylphosphonium
bromide
as
precursor
-CF
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(26), P. 4840 - 4844
Published: June 27, 2022
We
herein
describe
an
N-hetercyclic
carbene-catalyzed
three-component
acyldifluoromethylation
of
vinylarenes,
aldehydes,
and
NaSO2CF2H.
This
organocatalytic
approach
provides
a
practical
route
for
the
synthesis
pharmaceutically
relevant
α-aryl-β-difluormethyl
ketones
without
need
transition
metals
or
photocatalysts.
The
late-stage
drug
analogues
was
also
demonstrated.
reaction
design
employs
NaSO2CF2H
as
source
CF2H
radical
in
presence
oxidant
relay.
