A
novel
synthesis
method
has
been
developed
for
the
construction
of
functionalized
2,4-diarylpyridines.
The
reaction
involves
several
key
processes,
including
a
radical
Michael
occurring
twice,
two
SET
mechanisms,
proton
loss,
aldehyde
oxidation,
decarboxylation,
and
ring-opening
reaction.
All
these
processes
are
facilitated
by
refluxing
mixture
starting
materials
in
environmentally
benign
solvent,
propylene
carbonate
(PC),
with
oxidant
(air)
catalyst
Cu(OAc)2.
This
cascade
not
only
forms
new
bonds
but
also
cleaves
three
existing
single
pot.
protocol
presented
this
study
is
valuable
tool
synthesizing
unsymmetrical
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(10), P. 2762 - 2767
Published: Jan. 1, 2024
A
P(NMe2)3-catalyzed
[4
+
2]
annulation
of
2-amino-β-nitrostyrenes
and
β′-acetoxy
allenoates
followed
by
a
Zn/AcOH-mediated
reduction–hydroamination–isomerization
has
been
developed.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(5), P. 838 - 842
Published: Jan. 27, 2023
A
copper-catalyzed
annulation
of
O-acyl
oximes
with
cyclic
1,3-diones
has
been
developed
for
the
concise
synthesis
7,8-dihydroindolizin-5(6H)-ones
and
cyclohexanone-fused
furans
through
substituent-controlled
selective
radical
coupling
process.
2-Alkyl
undergo
C-C
coupling,
while
2-unsubstituted
C-O
coupling.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 8420 - 8434
Published: June 5, 2024
An
elegant
and
highly
concise
strategy
for
the
construction
of
coumarin-functionalized
pyrrolo[2,1-a]isoquinolines
from
available
propargylamines
isoquinolinium
N-ylides
has
been
disclosed.
In
this
reaction,
acted
as
a
C2
synthon
to
form
coumarin
ring
well
1,3-dipole
construct
pyrrole
in
single
pot.
This
cascade
process
involves
1,4-conjugate
addition/lactonization/1,3-dipolar
cycloaddition
four
chemical
bonds
(one
C–O
bond
three
C–C
bonds)
two
new
heterocyclic
skeletons.
Additionally,
most
these
compounds
showed
good
fluorescence
properties
exhibited
high
molar
extinction
coefficient
large
Stokes
shifts.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(15), P. 4214 - 4218
Published: Jan. 1, 2024
A
[3
+
1
1]
cascade
annulation
reaction
for
the
divergent
construction
of
trisubstituted
indolizines
using
sulfoxonium
ylides,
BrCF
2
CO
Me
and
pyridinium
salts
as
readily
available
substrates
has
been
developed.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(4), P. 798 - 803
Published: Jan. 22, 2024
A
(3+2)
cycloaddition
of
heteroaromatic
N-ylides
with
sulfenes,
which
are
generated
in
situ
from
sulfonyl
chlorides,
has
been
developed.
variety
ylides
were
transformed
into
the
corresponding
sulfone-embedded
N-fused
heterocycles
high
yields.
Hexafluoroisopropyl
mesylate
was
demonstrated
to
be
a
suitable
reactant
for
quinolinium
ylides.
Furthermore,
this
could
performed
an
ylide
prepared
by
Cu-catalyzed
transfer
reaction
one-pot
manner,
extending
substrate
scope
unisolable
ylide.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(13), P. 3313 - 3320
Published: Jan. 1, 2023
A
novel
light
induced
8-endo
sulfonyl
cyclization
to
medium-sized
benzo[
b
]azocines
is
developed.
DFT
calculations
rationalize
the
rate-determining
step
and
chemoselectivity
observed
in
this
transformation.
