Green Synthesis and Catalysis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 1, 2024
The
preparation
of
functionalized
ketones
occupies
an
important
position
in
synthetic
organic
chemistry
because
are
ubiquitous
structural
motifs
a
broad
range
compounds
with
various
applications.
conversion
aldehydes
to
is
one
the
most
convenient
and
straightforward
routes,
which
has
been
extensively
studied
field
transition
metal
catalysis.
In
comparison,
transition-metal-free
remains
underdeveloped.
last
decade,
emergence
new
advances
upgraded
toolbox
for
ketone
synthesis
from
absence
metals.
this
review,
we
have
mainly
summarized
three
types
reactions
enabling
ketones,
emphasis
on
those
involving
main
group
element
ACS Organic & Inorganic Au,
Journal Year:
2023,
Volume and Issue:
3(3), P. 136 - 142
Published: March 27, 2023
We
report
the
isolation
and
study
of
dimers
stemming
from
popular
thiazol-2-ylidene
organocatalysts.
The
model
featuring
2,6-di(isopropyl)phenyl
(Dipp)
N-substituents
was
found
to
be
a
stronger
reducing
agent
(Eox
=
-0.8
V
vs
SCE)
than
bis(thiazol-2-ylidenes)
previously
studied
in
literature.
In
addition,
remarkable
potential
gap
between
first
second
oxidation
dimer
also
allows
for
corresponding
air-persistent
radical
cation.
latter
is
an
unexpected
efficient
promoter
transformation
α-bromoamides
into
oxindoles.
Synlett,
Journal Year:
2023,
Volume and Issue:
35(04), P. 445 - 450
Published: Aug. 1, 2023
Abstract
Cooperative
NHC
and
photoredox
catalysis
has
gained
significant
attention
as
an
emerging
research
field
in
recent
years.
Herein,
we
report
a
cyclizing
aminoacylation
of
alkenes,
which
is
enabled
through
the
combination
these
two
catalytic
modes.
The
key
step
radical/radical
cross-coupling
between
persistent
ketyl
radical
transient
benzylic
or
aliphatic
C-radical,
generated
cyclization
oxidatively
formed
amidyl
radical.
Several
carbamates,
amides
sulfonamides
containing
alkene
moiety
different
acyl
fluorides
can
be
used
substrates.
resulting
products
are
obtained
moderate
to
good
yields.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(24), P. 17134 - 17143
Published: Dec. 6, 2023
It
is
significant
to
develop
novel
difluoromethylation
methods
because
of
the
important
roles
difluoromethyl
groups
in
medicinal
chemistry
and
material
industries.
Here,
we
developed
a
difluoromethylation–carboxylation
difluoromethylation–deuteration
method
triggered
by
radical
generated
electroreduction
stable
easily
available
difluoromethyltriphenylphosphonium
bromide.
Various
molecules
containing
carboxyl
or
deuterium
can
be
synthesized
through
this
method.
The
establishment
will
provide
an
alternative
reactions.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(45), P. 8168 - 8172
Published: Nov. 3, 2023
Despite
the
importance
of
monofluoroalkyl
groups
in
pharmaceutically
relevant
molecules,
catalytic
protocols
for
their
incorporation
into
alkenes
remain
limited.
We
describe
herein
a
three-component
acylmonofluoroalkylation
introduction
such
moieties
through
an
unprecedented
cooperativity
between
N-heterocyclic
carbene
catalyst
and
earth-abundant
Mn(II)
complex.
This
general
method
can
be
applied
to
variety
alkenes,
including
styrenes,
1,3-enynes,
allenes,
as
well
complex
substrates
containing
natural
product
drug
motifs.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(18), P. 3784 - 3788
Published: Jan. 1, 2023
An
NHC-catalyzed
[3
+
2
1]
annulation
of
vinyl
azides,
aldehydes,
and
Togni’s
reagents
was
reported.
The
cascade
involves
SET
redox
transformation,
denitrogenated
radical
migration,
C–N
coupling,
defluorinated
cyclization.
Chemistry - An Asian Journal,
Journal Year:
2023,
Volume and Issue:
18(19)
Published: Aug. 18, 2023
Abstract
Under
typical
copper‐catalyzed
hydroboration
conditions,
β
‐(trifluoromethyl)styrenes
demonstrate
unusal
reactivities
by
forming
difluoromethylated
alkenes
via
a
net
protodefluorination
process.
This
is
also
distinct
from
trifluoromethyl
with
alkyl
substituents
where
defluoroborylation
products
predominate.
Green Synthesis and Catalysis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 1, 2024
The
preparation
of
functionalized
ketones
occupies
an
important
position
in
synthetic
organic
chemistry
because
are
ubiquitous
structural
motifs
a
broad
range
compounds
with
various
applications.
conversion
aldehydes
to
is
one
the
most
convenient
and
straightforward
routes,
which
has
been
extensively
studied
field
transition
metal
catalysis.
In
comparison,
transition-metal-free
remains
underdeveloped.
last
decade,
emergence
new
advances
upgraded
toolbox
for
ketone
synthesis
from
absence
metals.
this
review,
we
have
mainly
summarized
three
types
reactions
enabling
ketones,
emphasis
on
those
involving
main
group
element
