Modular synthesis of congested β^2,2-amino acids via the merger of photocatalysis and oxidative functionalisations

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(11), P. 1456 - 1459

Published: Jan. 1, 2024

A two-step protocol for the modular synthesis of β 2 - and α-quaternary 2,2 -amino acid derivatives is reported.

Language: Английский

Base-Promoted Annulation of o-(Cyanomethyl)aryl Thioester with Thiophenols to Access 3-Thiolated Isoquinolones

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

An efficient annulation approach to forming 3-thiolated isoquinolones from readily accessible o-(cyanomethyl)aryl thioesters and thiophenols has been established. This metal-free is achieved by taking advantage of solvent-free reactions with no precaution exclude water or air, enabling broad substrate scope good functionality tolerance. Furthermore, the protocol scalable offers facile access valuable without chromatography.

Language: Английский

Photoredox-Enabled Deconstructive [5 + 1] Annulation Approach to Isoquinolones from Indanones in Water

Organic Letters, Journal Year: 2024, Volume and Issue: 26(15), P. 3043 - 3047

Published: April 5, 2024

We disclose a deconstructive [5 + 1] annulation protocol for the synthesis of isoquinolones through nitrogen insertion into abundant indanones. This method exploits photoredox-catalyzed ring-opening oxime esters. The reaction proceeds smoothly with water as medium and tolerates range functional groups on diverse thiophenols, amines, or Moreover, representative exhibit promising antifungal activities.

Language: Английский