Introduction of the year 2023 DOI Creative Commons

M. A. Quindt,

Taegeun Jo, Luca Nicchio

et al.

Royal Society of Chemistry eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 31

Published: Dec. 18, 2024

In the introduction chapter we introduce volume and its three sections, namely critical reviews, highlights on recent “hot” topics SPR lectures in photochemistry. Furthermore, includes most significant editorial releases photochemistry 2023, by presenting awards, handbooks, special issues reviews.

Language: Английский

Phototriggered Self-Catalyzed Phosphorylation of 3,4-Dihydroquinoxalin-2(1H)-ones with Diarylphosphine Oxides in EtOH DOI
Yanfang Jiang, Wen‐Tao Ouyang,

Hong‐Tao Ji

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

A highly effective external photocatalyst- and additive-free method for the phosphorylation of 3,4-dihydroquinoxalin-2(1

Language: Английский

Citations

12
Adamantane-Quinoxalone Hybrids: Precision Chemotypes and Their Molecular Mechanisms in Acute Myeloid Leukemia DOI
Sangita Dattatray Shinde,

Ambika Chamoli,

Sai Swetha Uppalapati

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Acute myeloid leukemia (AML) is an aggressive blood cancer with a poor prognosis, especially when diagnosed late. Around 10–15% of cases involve the specific chromosomal abnormality t(8;21), which drives uncontrolled cell proliferation and contributes to disease onset. Despite advances in AML research treatment protocols, outcomes for t(8;21) remain stagnant, as patients receive standard, nonspecific chemotherapies. This one-size-fits-all approach targets both cancerous healthy cells, leading unwanted toxicity highlighting urgent need targeted therapies. In this study, we present precision chemotype based on quinoxalone-tethered adamantane framework developed via metal- light-free protocol. The compound selectively inhibits induces death by disrupting growth metabolic pathways, demonstrated through bioassays, RNA sequencing, proteomic analysis. Notably, it spares other leukemic solid underscoring its specificity potential therapy AML.

Language: Английский

Citations

1
Visible Light‐Enabled Decarboxylative Alkylation of Quinoxalin‐2(1H)‐ones using Alkyl Carboxylic Acids via Energy Transfer Process DOI
Anoop Sharma, Nihal Singh, Raman Kumar

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(12), P. 2735 - 2741

Published: April 20, 2024

Abstract Here in, we describe the photochemical decarboxylative alkylation of quinoxalin‐2(1 H )‐ones using commercially accessible carboxylic acids with oxygen as sole oxidant through energy transfer process. The coupling diverse array alkyl (1° to 3°) and bioactive is successfully accomplished achieve desired alkylated products.

Language: Английский

Citations

4
Visible‐light Induced C‐3 Carbamoylation of Quinoxalinones Assisted by EDA Complex DOI

Aznur Azim,

Tanumoy Mandal,

Vidhul Vasudevan

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: June 13, 2024

Abstract A visible‐light‐promoted strategy for the decarboxylative C‐3 carbamoylation of quinoxalinone scaffolds is developed. This approach initiates through formation an EDA complex between oxamic acid and quinoxalinone. Successive SET construct C−C bond. method utilizes aerial oxygen as green oxidant eradicates process from use external photocatalysts transition metals. Detailed synthetic photophysical studies enlighten reaction pathway.

Language: Английский

Citations

4
Visible Light-Induced Radical Cascade Functionalization of Quinoxalin-2(1H)-ones: Three-Component 1,2-Di(hetero)arylation Approach with Styrenes and Thianthrenium Salts DOI

Sudip Sau,

Shinobu Takizawa, Hun Young Kim

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(41), P. 8821 - 8826

Published: Oct. 9, 2024

The additive-free visible light-induced three-component 1,2-di(hetero)arylation of styrenes was developed using quinoxalin-2(1

Language: Английский

Citations

4
Electron-Donor-Mediated Divergent Transformation of Br–RF via EDA Complex for the Synthesis of Fluorine-Containing Oxindoles and Amides DOI
Shupeng Zhang,

Jin-Xin Lan,

Mei-Ling Yang

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(46), P. 9990 - 9995

Published: Nov. 11, 2024

We have developed an unprecedented electron-donor-controlled divergent reaction between

Language: Английский

Citations

4
Self-Catalyzed Sono-Photoinduced Arylation of Quinoxalin-2(1H)-ones with Arylhydrazines DOI

Yao-Dan Xu,

Yang Xing,

Hong‐Tao Ji

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Herein, the first example of self-catalyzed sono-photoinduced carbon-carbon bond formation was described. Combining advantages phototriggered self-catalysis and ultrasonic catalysis, a wide range 3-arylquinoxalin-2(1

Language: Английский

Citations

4
Advances in Photoinduced Minisci-like Reactions DOI

Mario Martos,

Irene Bosque, José C. González‐Gómez

et al.

Synthesis, Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Abstract The Minisci reaction, which has been around for more than five decades, is still the preferred tool straightforward alkylation of basic heteroarenes. recent developments in photocatalysis have opened novel pathways radical generation under milder and sustainable conditions. Implementing this approach into reaction renewed interest transformation, attractive per se Medicinal Chemistry. Aspects such as sacrificial oxidants, catalysts, specific conditions should be carefully examined to evaluate practicability protocol. This short review focuses on advances (2020 February 2024) photoinduced Minisci-type reactions, emphasizing sustainability. 1 Introduction 2 Using Noble-Metal-Based Photocatalysts 3 Noble-Metal-Free Methods Sacrificial Oxidants 4 Without 5 Conclusions Perspectives

Language: Английский

Citations

3
Visible-Light-Induced Cascade Cyclization of 1-(2-(Arylethynyl)benzoyl)indoles into Sulfonated Benazepino[1,2-a]indolones DOI
Lanwei Guo, Zhiyang Zhang, Fuyi Zhang

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(50), P. 10982 - 10987

Published: Dec. 10, 2024

1-(2-(Arylethynyl)benzoyl)indoles were developed as an innovative scaffold for radical cascade cyclization under visible-light and mild conditions, enabling efficient synthesis of sulfonated benazepino[1,2-

Language: Английский

Citations

2
Photoredox Cross Dehydrogenative C(sp2)-C(sp3) Coupling of Heteroarenes with Secondary Amines through 1,5-HAT DOI

Vinjamuri Srinivasu,

Swadhin Pattanaik,

Devarajulu Sureshkumar

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(72), P. 9757 - 9760

Published: Jan. 1, 2024

The functionalization of α-C(sp

Language: Английский

Citations

1