Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 411, P. 135740 - 135740
Published: April 1, 2024
Language: Английский
ECS Sensors Plus, Journal Year: 2024, Volume and Issue: 3(1), P. 011601 - 011601
Published: March 1, 2024
There is a plethora of electrochemical biosensors developed for ultrasensitive detection clinically relevant biomarkers. However, many these systems lose their performance in heterogeneous clinical samples and are too complex to be operated by end users at the point-of-care (POC), prohibiting commercial success. Integration with sample processing technology addresses both challenges; however, it adds manufacturing complexity overall cost systems. Herein, we review different components biosensor avenues creating fully integrated In context integration, focus on discussing trade-offs between sensing performance, cost, scalable guide readers toward designing new commercialization potential.
Language: Английский
Citations
38
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: July 3, 2024
Early-stage disease detection, particularly in Point-Of-Care (POC) wearable formats, assumes pivotal role advancing healthcare services and precision-medicine. Public benefits of early detection extend beyond cost-effectively promoting outcomes, to also include reducing the risk comorbid diseases. Technological advancements enabling POC biomarker recognition empower discovery new markers for various health conditions. Integration wearables with intelligent frameworks represents ground-breaking innovations automation operations, conducting advanced large-scale data analysis, generating predictive models, facilitating remote guided clinical decision-making. These substantially alleviate socioeconomic burdens, creating a paradigm shift diagnostics, revolutionizing medical assessments technology development. This review explores critical topics recent progress development 1) systems solutions physiological monitoring, as well 2) discussing current trends adoption smart technologies within settings developing biological assays, ultimately 3) exploring utilities platforms discovery. Additionally, translation from research labs broader applications. It addresses associated risks, biases, challenges widespread Artificial Intelligence (AI) integration diagnostics systems, while systematically outlining potential prospects, challenges, opportunities.
Language: Английский
Citations
24
Deleted Journal, Journal Year: 2024, Volume and Issue: 2(1)
Published: Jan. 1, 2024
Abstract Intelligent point‐of‐care testing (iPOCT) is a rapidly advancing technology that combines molecular detection and bio‐sensing techniques to achieve instant accurate analysis through advanced sensors intelligent algorithms. Molecular technologies, such as nucleic acid isothermal amplification, biochip microfluidics, enable rapid of the chemical composition concentration samples, thereby determining their presence. Bio‐sensing utilizes recognition properties biomolecules in conjunction with detect specific or biological processes. iPOCT holds broad prospects for application field healthcare expected enhance sensitivity, accuracy, intelligence further development. In this review, we delineate developmental journey iPOCT, followed by discussion on principles technology, well design devices health monitoring disease diagnosis. Furthermore, showcased illustrative examples applications diagnosis, highlighting integration wearable smartphones attaining more precise personalized diagnostic results.
Language: Английский
Citations
17
ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(2), P. 657 - 676
Published: Jan. 19, 2024
The fusion of MXene-based materials with microfluidics not only presents a dynamic and promising avenue for innovation but also opens up new possibilities across various scientific technological domains. This Perspective delves into the intricate synergy between MXenes microfluidics, underscoring their collective potential in material science, sensing, energy storage, biomedical research. intersection disciplines anticipates future advancements MXene synthesis functionalization as well progress advanced sensing technologies, storage solutions, environmental applications, breakthroughs. Crucially, manufacturing commercialization microfluidic devices, coupled interdisciplinary collaborations, stand pivotal considerations. Envisioning where collaboratively shape our landscape, addressing challenges propelling forward necessitates thoughtful approach. viewpoint provides comprehensive assessment current state field while outlining prospects integration entities microfluidics.
Language: Английский
Citations
17
ACS Sensors, Journal Year: 2024, Volume and Issue: 9(6), P. 3066 - 3074
Published: June 15, 2024
Point-of-care testing (POCT) devices play a crucial role as tools for disease diagnostics, and the integration of biorecognition elements with electronic components into these widens their functionalities facilitates development complex quantitative assays. Unfortunately, biosensors that exploit large conventional IgG antibodies to capture relevant biomarkers are often limited in terms sensitivity, selectivity, storage stability, considerably restricting use POCT real-world applications. Therefore, we used nanobodies they more suitable fabricating electrochemical near-field communication (NFC) technology. Moreover, flow-through microfluidic device was implemented this system detection C-reactive protein (CRP), an inflammation biomarker, model analyte. The resulting sensors not only have high sensitivity portability but also retain automated sequential flow properties through capillary transport without need external pump. We compared accuracy CRP analyses between commercial PalmSens4 NFC-based potentiostats. Furthermore, sensor reliability evaluated using three biological samples (artificial serum, plasma, whole blood any pretreatment). This platform will streamline by combining operational simplicity, low cost, fast analysis, portability.
Language: Английский
Citations
17
Environmental Pollution, Journal Year: 2022, Volume and Issue: 316, P. 120695 - 120695
Published: Nov. 21, 2022
Language: Английский
Citations
50
Bioengineering & Translational Medicine, Journal Year: 2023, Volume and Issue: 8(3)
Published: Jan. 3, 2023
Abstract Microbial pathogens have threatened the world due to their pathogenicity and ability spread in communities. The conventional laboratory‐based diagnostics of microbes such as bacteria viruses need bulky expensive experimental instruments skilled personnel which limits usage resource‐limited settings. biosensors‐based point‐of‐care (POC) shown huge potential detect microbial a faster, cost‐effective, user‐friendly manner. use various transducers electrochemical optical along with microfluidic integrated biosensors further enhances sensitivity selectivity detection. Additionally, microfluidic‐based offer advantages multiplexed detection analyte deal nanoliters volume fluid an portable platform. In present review, we discussed design fabrication POCT devices for include bacteria, viruses, fungi, parasites. techniques current advances this field terms platforms that mainly microfluidic‐ based approaches smartphone Internet‐of‐things (IoT) Internet‐of‐Medical‐Things (IoMT) systems been highlighted. Further, availability commercial will be briefed. end, challenges while POC expected future biosensing discussed. biosensor‐based IoT/IoMT usually collect data track community infectious diseases would beneficial better preparedness futuristic pandemics is prevent social economic losses.
Language: Английский
Citations
39
Advanced Biology, Journal Year: 2023, Volume and Issue: 7(6)
Published: Feb. 8, 2023
Abstract Cryopreservation is the most prevalent method of long‐term cell preservation. Effective cryopreservation depends on freezing, adequate storage, and correct thawing techniques. Recent advances in techniques minimize cellular damage which occurs while processing samples. This article focuses fundamentals how they can be implemented a variety clinical settings. The presents brief description each standard procedures, such as slow freezing vitrification. Alongside that, membrane permeating nonpermeating cryoprotectants are briefly discussed, along with current advancements field variables influencing process. diminution cryoinjury incurred by via resuscitation process will also highlighted. In end application many fields, special emphasis stem preservation presented. Furthermore, challenges implementing futuristic scope fields illustrated herein. content this review sheds light various ways to enhance output improving revival.
Language: Английский
Citations
35
Analytical Methods, Journal Year: 2023, Volume and Issue: 15(18), P. 2154 - 2180
Published: Jan. 1, 2023
POCT technology has shown promise for rapid diagnosis. nanoparticle-based immunoassays can be used to detect different targets with high sensitivity, selectivity, and affordability.
Language: Английский
Citations
28
Micromachines, Journal Year: 2023, Volume and Issue: 14(4), P. 826 - 826
Published: April 8, 2023
Microfluidics is a rapidly growing discipline that involves studying and manipulating fluids at reduced length scale volume, typically on the of micro- or nanoliters. Under larger surface-to-volume ratio, advantages low reagent consumption, faster reaction kinetics, more compact systems are evident in microfluidics. However, miniaturization microfluidic chips introduces challenges stricter tolerances designing controlling them for interdisciplinary applications. Recent advances artificial intelligence (AI) have brought innovation to microfluidics from design, simulation, automation, optimization bioanalysis data analytics. In microfluidics, Navier-Stokes equations, which partial differential equations describing viscous fluid motion complete form known not general analytical solution, can be simplified fair performance through numerical approximation due inertia laminar flow. Approximation using neural networks trained by rules physical knowledge new possibility predict physicochemical nature. The combination automation produce large amounts data, where features patterns difficult discern human extracted machine learning. Therefore, integration with AI potential revolutionize workflow enabling precision control analysis. Deployment smart may tremendously beneficial various applications future, including high-throughput drug discovery, rapid point-of-care-testing (POCT), personalized medicine. this review, we summarize key integrated discuss outlook possibilities combining
Language: Английский
Citations
23